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Cautions in the Adoption of Common Reference Intervals

Department of Pathology, Division of Laboratory Medicine/Clinical Laboratories, P.O. Box 800214, Charlottesville, VA 22908-0214

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Transferability of test results for a given analyte has long been a goal of the laboratory community. Achievement of transferability will require development of standardized methods that have the least possible measurement uncertainty and are traceable to reference standards. Once accomplished, transferability will allow comparison of laboratory results regardless of the individual performing laboratory and will provide long-term stability of results, enabling longitudinal results to be followed for individual patients. Transferability remains an elusive goal, however. Analytical hindrances include the lack of established reference measurement systems for many quantities, lack of traceability of field methods to the reference system, and lot-to-lot variability in reagents and calibrators.

When no population-specific differences exist, the use of common reference intervals for transferable tests can be envisioned. Enthusiasm for the use of common reference intervals has grown . . . [Full Text of this Article]

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				F. Ceriotti, R. Hinzmann, and M. Panteghini Reference intervals: the way forward Ann Clin Biochem, January 1, 2009; 46(1): 8 - 17. [Abstract] [Full Text] [PDF]