Clinical Chemistry
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Clinical Chemistry 54: 612, 2008; 10.1373/clinchem.2007.094060
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(Clinical Chemistry. 2008;54:612.)
© 2008 American Association for Clinical Chemistry, Inc.

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Use and Interpretation of Common Statistical Tests in Method Comparison Studies

James O. Westgard1

1 University of Wisconsin CLS Program, Madison, WI.

Address correspondence to this author at: James O. Westgard, University of Wisconsin CLS Program, 1300 University Avenue, Madison, WI 53706. E-mail james@westgard.com.

The first 20% of the full text of this article appears below.

Feature Article: Westgard JO, Hunt MR. Use and interpretation of common statistical tests in method comparison studies. Clin Chem 1973;19:49–57.1

Marian Hunt and I published this paper to improve the understanding and application of commonly used statistics in method validation studies. We specifically wanted to clarify the misuse of the correlation coefficient and t-test statistics, and to point out important factors that affected the reliability of least squares statistics. This paper also provided some direction in making decisions on the acceptability of a method by using statistics to estimate the sizes of analytical errors. A subsequent paper (1) provided criteria for comparing those estimates of errors with quality standards that defined . . . [Full Text of this Article]






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