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Clinical Chemistry 54: 621-623, 2008; 10.1373/clinchem.2007.099739
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(Clinical Chemistry. 2008;54:621-623.)
© 2008 American Association for Clinical Chemistry, Inc.

Letters

The –590CC Genotype in the IL4 Gene as a Strong Predictive Factor for the Development of Hypothyroidism in Hashimoto Disease

Takashi Nanba1, Mikio Watanabe1, Takashi Akamizu2 and Yoshinori Iwatani1,a

1 Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, Japan
2 Translational Research Center, Kyoto University Hospital, Kyoto University School of Medicine, Kyoto, Japan

aAddress correspondence to this author at: Department of Biomedical Informatics Division of Health Sciences, Osaka University Graduate School of Medicine, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan, Fax 81-6-6879-2592 e-mail iwatani@sahs.med.osaka-u.ac.jp

The first 20% of the full text of this article appears below.


To the Editor:

The severity of Hashimoto disease (HD) varies among patients and is difficult to predict when the disease is in the subclinical state and diagnosed by the presence of thyroid-specific autoantibody. Likewise, the intractability of Graves disease (GD) is difficult to predict. Autoimmune thyroid destruction that underlies both diseases is strongly determined by T-cell cytotoxicity, which is activated by interferon (IFN)-{gamma} (1), and the T allele in +874A/T polymorphism of the interferon gamma (IFNG) gene, which promotes increased IFN-{gamma} production, has been noted more frequently among patients with severe HD (2). Cytokine balance between T-helper 1 (Th1) cytokines, such as IFN-{gamma}, and Th2 cytokines is important in immune regulation (3). Therefore, it is possible that Th2 cytokines may also affect the severity of . . . [Full Text of this Article]






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