Clinical Chemistry
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Clinical Chemistry 54: 923-924, 2008; 10.1373/clinchem.2007.097758
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(Clinical Chemistry. 2008;54:923-924.)
© 2008 American Association for Clinical Chemistry, Inc.

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High-Density Lipoproteins: The Neglected Stepchildren Whose Importance as a Risk Factor Continues to Be Defined

G. Russell Warnick1,a

1 Berkeley Heartlab, Alameda, CA.

aAddress correspondence to this author at: Berkeley HeartLab, Suite 100, 960 Atlantic Avenue, Alameda, CA. Fax 650-267-3594; e-mail grwarnick@bhlinc.com.

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Featured Article: Warnick GR, Benderson J, Albers JJ. Dextran Sulfate-Mg2+ Precipitation Procedure for Quantitation of High-Density-Lipoprotein Cholesterol. Clin Chem 1982;28:1379–88.1

The inverse association of HDL-cholesterol (HDL-C) with coronary artery disease (CAD) risk was rediscovered in the mid-1970s, coinciding with diagnostics companies seeking a revenue replacement for lipoprotein electrophoresis, the use of which was fading because lipoprotein phenotyping had been discredited. As a result, HDL-C measurements rapidly transitioned from specialty lipid research laboratories into general clinical practice, igniting interest in measurement methods. Our group at the Northwest Lipid Research Clinic at the University of Washington in Seattle had considerable interest in and experience with lipoproteins, especially HDLs, and we began publishing our observations in a series of methodological papers. As an indication of both the intense interest in HDL-C and the methodologic challenges of achieving reliable measurements, beginning in 1976 we and various collaborators published at least one HDL paper in Clinical Chemistry each and every year for a total of 12 years as well as 15 HDL papers in other journals. The . . . [Full Text of this Article]






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