Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 54: 1085-1086, 2008; 10.1373/clinchem.2007.100438
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ueland, P. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ueland, P. M.
Related Collections
Right arrow Citation Classics
(Clinical Chemistry. 2008;54:1085-1086.)
© 2008 American Association for Clinical Chemistry, Inc.

Citation Classics in Clinical Chemistry

Importance of Chemical Reduction in Plasma and Serum Homocysteine Analysis

Per Magne Ueland1

1 Section for Pharmacology, Institute of Medicine, University of Bergen and Haukeland Hospital, Bergen, Norway.

Address correspondence to this author at: Section for Pharmacology, Institute of Medicine, Armauer Hanssens hus, University of Bergen, 5021 Bergen, Norway. Fax 47-55-97 4605; e-mail per.ueland@ikb.uib.no

The first 20% of the full text of this article appears below.

Featured Article: Refsum H, Helland S, Ueland PM. Radioenzymic determination of homocysteine in plasma and urine. Clin Chem 1985;31:624–8.1

In 1977, as part of the research on which I based my PhD thesis, I purified S-adenosylhomocysteine hydrolase to homogeneity, and in the years that followed, my colleagues and I studied its role in the metabolism of S-adenosylhomocysteine in cells and animals treated with adenosine analogs. During these experiments, we gained knowledge about the catalytic properties of the enzyme, which enabled us to construct an enzymic assay for homocysteine in rat and mouse tissues as well as in plasma from mice(1). When this methodological work was being carried out in 1982, data on homocysteine were sparse and addressed limited aspects of homocysteine in health and disease, such as homocyst(e)ine in patients with the inborn error of homocystinuria, increased homocyst(e)ine (often the homocysteine-cysteine mixed disulfide) in patients with . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
D. W. Jacobsen
Total Plasma Homocysteine: The Mediator/Marker Controversy Continues
Clin. Chem., September 1, 2009; 55(9): 1742 - 1743.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American Association for Clinical Chemistry.