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Commentary

Department of Pathology & Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA.

Address correspondence to the author at: Department of Pathology & Laboratory Medicine, 7.103 Founders Pavilion, University of Pennsylvania Medical Center, 3400 Spruce St., Philadelphia, PA 19104. E-mail kricka@mail.med.upenn.edu

The first 20% of the full text of this article appears below.

Interferences in laboratory tests, immunoassays in particular, continue to be a significant challenge in clinical laboratory practice (1). A raised awareness to this type of analytical problem is important if laboratories are to avoid reporting incorrect test results. In spite of all efforts by the diagnostic community, interferences still occur, sometimes with disastrous consequences for the patient.

These 2 cases illustrate 2 different circumstances that led to the suspicion of assay interference. In the case reported by van der Watt et al., it was discordance in thyroid test results that alerted the laboratory, and in the case reported by Kellogg et al., investigation of a possible laboratory artifact was a component in the standard of care for the suspected . . . [Full Text of this Article]

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				A A A Ismail Interference from endogenous antibodies in automated immunoassays: what laboratorians need to know J. Clin. Pathol., August 1, 2009; 62(8): 673 - 678. [Abstract] [Full Text] [PDF]

				B E Fritz, R J Hauke, and D F Stickle New onset of heterophilic antibody interference in prostate-specific antigen measurement occurring during the period of post-prostatectomy prostate-specific antigen monitoring Ann Clin Biochem, May 1, 2009; 46(3): 253 - 256. [Abstract] [Full Text] [PDF]