Clinical Chemistry
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Clinical Chemistry 54: 1400, 2008; 10.1373/clinchem.2008.104836
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(Clinical Chemistry. 2008;54:1400.)
© 2008 American Association for Clinical Chemistry, Inc.

Citation Classic

Plasma Renin Activity: An Assay with Ongoing Clinical Relevance

Frej Fyhrquist1,a and Outi Saijonmaa1

1 The Minerva Institute of Medical Research and Department of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland.

aAddress correspondence to this author at: Minerva Institute for Medical Research, Haartmaninkatu 8, 00290 Helsinki, Finland. E-mail frej.fyhrquist@helsinki.fi.

The first 20% of the full text of this article appears below.

Featured Article: Fyhrquist F, Soveri P, Puutula L, Stenman U-H. Radioimmunoassay of plasma renin activity. Clin Chem 1976;22:250–6.2

In the early 1970s there was a growing need for reliable and clinically useful methods for the determination of the activity of the renin-angiotensin system. Bioassay methods for renin activity, although valuable in early research, were too cumbersome and unreliable for clinical use. RIAs for plasma angiotensin II were of limited clinical value because of their lack of specificity, the need for extraction procedures, and insufficient sensitivity. We therefore developed a sensitive and specific assay of plasma renin activity (PRA)1 . Plasma was acidified with a mixture of hydrochloric acid and the enzyme inhibitor hydroxyquinoline, to ensure optimal incubation pH (6.0) (1) and sufficient . . . [Full Text of this Article]






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