Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 55: 605-606, 2009. First published February 20, 2009; 10.1373/clinchem.2008.121855
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
clinchem.2008.121855v1
55/4/605    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bauer, M.
Right arrow Articles by Pertl, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bauer, M.
Right arrow Articles by Pertl, B.
(Clinical Chemistry. 2009;55:605-606.)
© 2009 American Association for Clinical Chemistry, Inc.

Editorials

On Targeting Cell-Free DNA in Urine: A Protocol for Optimized DNA Analysis

Margit Bauera and Barbara Pertl

Department of Obstetrics and Gynecology, Medical University Graz, Graz, Austria.

aAddress correspondence to this author at: Department of Obstetrics and Gynecology, Medical University Graz, Auenbruggerplatz 14, A-8036, Graz, Austria. E-mail margit.holzapfel-bauer@meduni-graz.at.

The first 20% of the full text of this article appears below.

This is not the first editorial in Clinical Chemistry dedicated to the testing of urine for cell-free DNA. In 2000 Lo(1) highlighted the findings of Botezatu et al.(2), who were the first to describe a transfer of DNA across the kidney barrier into urine. The origins of detected transrenal DNA sequences were carcinomas, blood transfusions, and, in pregnant women, the fetus. Following this first report, some pioneering work was done in transplant medicine. Urinary microchimerism was found in women after receiving kidney transplants from males(3)(4). In a quantitative analysis it was demonstrated that transplant-derived DNA was increased during graft rejection, indicating a potential marker for transplant control(4).

Later, attempts were made to detect cell-free fetal DNA in maternal urine. However, maternal urine . . . [Full Text of this Article]






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2009 by the American Association for Clinical Chemistry.