Clinical Chemistry
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Clinical Chemistry 55: 1423-1424, 2009; 10.1373/clinchem.2008.122283
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(Clinical Chemistry. 2009;55:1423-1424.)
© 2009 American Association for Clinical Chemistry, Inc.


Clinical Case Study

Commentary

Charles E. Alpers

Department of Pathology, University of Washington Medical Center, Seattle, WA.

Address correspondence to the author at: University of Washington Medical Center, Department of Pathology, 1959 NE Pacific St., Box 356100, Seattle, WA 98195. E-mail calp@u.washington.edu.

The first 20% of the full text of this article appears below.

Schnable et al. describe a patient with a nearly 20-year history of hepatitis C virus (HCV) infection who developed acute manifestations of glomerulonephritis associated with concurrent cryoglobulinemia. A renal biopsy demonstrated "proliferative glomerulonephritis" that we are meant to infer was membranoproliferative glomerulonephritis of the type typically associated with cryoglobulinemia and HCV infection.

HCV has been associated with multiple extrahepatic manifestations, including cryoglobulinemia, glomerulonephritis, skin disorders (porphyria cutanea tarda, lichen planus), arthritis, a siccalike syndrome, and lymphoproliferative . . . [Full Text of this Article]







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