Clinical Chemistry
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Clinical Chemistry 55: 1431-1433, 2009. First published April 30, 2009; 10.1373/clinchem.2008.121913
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(Clinical Chemistry. 2009;55:1431-1433.)
© 2009 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Glomerular Filtration Rate Is a Confounder for the Measurement of Soluble Mesothelin in Serum

Kevin Hollevoet2, Dirk Bernard3, Frank De Geeter4, Natascha Walgraeve4, Anja Van den Eeckhaut4, Raymond Vanholder2, Christophe Van de Wiele5, Veronique Stove6, Jan P. van Meerbeeck2 and Joris R. Delanghe6,a

2 Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium, Departments of, 3 Clinical Chemistry and, 4 Nuclear Medicine, AZ Sint-Jan AV, Bruges, Belgium, Departments of, 5 Nuclear Medicine and, 6 Clinical Chemistry, Ghent University Hospital, Ghent, Belgium

aAddress correspondence to this author at: Department of Clinical Chemistry, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium, Fax 32-9-3324985, E-mail Joris.Delanghe@ugent.be

The first 20% of the full text of this article appears below.


To the Editor:

The mesothelin gene encodes a 71-kDa precursor protein that is subsequently cleaved into a soluble megakaryocyte potentiating factor and a membrane-bound part, mesothelin. Mesothelin can be shed as "soluble mesothelin" or "soluble mesothelin-related protein" (SMRP),1 which is an approximately 40-kDa biomarker of malignant mesothelioma, an asbestos-related cancer (1). Mesothelioma typically occurs in middle-aged men, and the renal function or the glomerular filtration rate (GFR) can occasionally decrease in these patients and in individuals at risk of developing mesothelioma. Renal impairment leads to the accumulation of low molecular weight proteins in the blood [e.g., cystatin C (13 kDa) and β-trace protein (BTP) (23–29 kDa)], and these proteins have been used as markers of the GFR. Such renal impairment can also cause the accumulation of soluble mesothelin, as has previously been reported for a limited number of cases(2). Our aim, therefore, was to thoroughly investigate the impact of renal function on serum SMRP concentrations.

We enrolled 66 individuals (49 men and 17 women; median age, 58 years; range, 24–80 years), who were referred for measurement of 51Cr-EDTA clearance to estimate the GFR. We excluded patients with asbestos-related diseases/malignancies, patients with endometrial, ovarian, cervix, . . . [Full Text of this Article]






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Copyright © 2009 by the American Association for Clinical Chemistry.