Patient HIV-RNA copies (n <400/mL) CD4+ counts (n = 400–1530/µL) Other antibiotics Antiretroviral Serum concentration Time post dose, h Comments 1 3576 85 Dapsone, 100 mg qda Stavudine, 40 mg bid <LOQ 8 Attempt to rescue from monotherapy treatment failure, ??b compliance Lamivudine, 150 mg bid <LOQ 8 Ritonavir, 600 mg bid 10.1 mg/L 2 2 14 790 60 Hydroxyurea, 500 mg bid Didanosine, 400 mg qd <LOQ 4 Attempt to rescue from monotherapy treatment failure, good compliance Stavudine, 40 mg bid <LOQ 6 Nevirapine, 200 mg bid 3.8 mg/L 6 3 3041 383 Bactrim DS, qd Didanosine, 200 mg bid <LOQ 3 Attempt to rescue from monotherapy treatment failure, good compliance January 1998 Clarithromycin, 500 mg bid Stavudine, 40 mg bid <LOQ 5 Ethambutol, 1000 mg qd Ritonavir, 400 mg bid 3.3 mg/L 5 Fluconazole, 200 mg qd Saquinavir, 400 mg bid 720 µg/L 5 May 1998 28 319 237 Bactrim DS, qd Didanosine, 200 mg bid <LOQ 1 Attempt to rescue from polytherapy treatment failure, good compliance Clarithromycin, 500 mg bid Stavudine, 40 mg bid 0.24 mg/L 3 Ethambutol, 1000 mg qd Neveripine, 200 mg bid 8.4 mg/L 3 Fluconazole, 200 mg qd Nelfinavir, 1 mg tid 3.2 mg/L 3 4 <104 405 None Lamivudine, 150 mg bid 1.8 mg/L 2 Good response to polytherapy in naive patient, good compliance Zidovudine, 300 mg bid 1.1 mg/L 2 Indinavir, 800 mg q8h 9.9 mg/L 2 4 Lamivudine, 150 mg bid 0.8 mg/L 7 Trough concentration, same day Zidovudine, 300 mg bid 0.5 mg/L 7 Indinavir, 800 mg q8h 6.2 mg/L 7 5 <247 1228 Lamivudine, 150 mg bid 0.2 mg/L 2 Good response to polytherapy in naive patient, good compliance Zidovudine, 300 mg bid 0.01 mg/L 2 Indinavir, 800 mg q8h 5.2 mg/L 2 5 Lamivudine, 150 mg bid 0.4 mg/L 6 Trough concentration, same day Zidovudine, 300 mg bid 0.04 mg/L 6 Indinavir, 800 mg q8h 0.5 mg/L 6 6 6721 103 Hydroxyurea, 500 mg bid Didanosine, 200 mg bid <0.01 mg/L 0 Attempt to rescue from monotherapy treatment failure, ?? compliance Stavudine, 40 mg bid 0.25 mg/L 1.5 Indinavir, 800 mg q8h 0.6 mg/L 1.5 6 Didanosine, 200 mg bid <0.01 mg/L 3 Trough concentration, same day Stavudine, 40 mg bid <0.02 mg/L 5 Indinavir, 800 mg q8h 0.2 mg/L 5

Patient HIV-RNA copies (n <400/mL) CD4+ counts (n = 400–1530/µL) Other antibiotics Antiretroviral Serum concentration Time post dose, h Comments 7 <117 238 Azithromycin, 500 mg Stavudine, 40 mg bid 0.5 mg/L 2 Good response to polytherapy in naive patient, good compliance Bactrim DS, qd Lamivudine, 150 mg bid 1.7 mg/L 2 Ethambutol, 800 mg bid Nelfinavir, 750 mg tid 4.3 mg/L 2 Rifabutin, 150 mg qd 7 Stavudine, 40 mg bid <0.01 mg/L 10 Trough concentration, same day Lamivudine, 150 mg bid 0.3 mg/L 10 Nelfinavir, 750 mg tid 1.3 mg/L 10 8 <50 774 None Lamivudine, 150 mg bid 0.1 mg/L 2 Good response to polytherapy in naive patient, good compliance Zidovudine, 300 mg bid 0.1 mg/L 2 Indinavir, 800 mg q8h 3.2 mg/L 2 8 Lamivudine, 150 mg bid <0.1 mg/L 6 Trough concentration, same day Zidovudine, 300 mg bid <0.01 mg/L 6 Indinavir, 800 mg q8h 0.3 mg/L 6 9 496 438 Azithromycin, 1200 mg qwk Lamivudine, 150 mg bid 0.6 mg/L 2 Good response to polytherapy in naive patient, unknown compliance Bactrim DS, qd Zidovudine, 200 mg tid <0.01 mg/L 2 Saquinavir, 600 mg tid 22 µg/L 2 9 Lamivudine, 150 mg bid 0.1 mg/L 10 Trough concentration, same day Zidovudine, 200 mg tid <0.01 mg/L 10 Saquinavir, 600 mg tid <10 µg/L 10 10 <400 102 Azithromycin, 1200 mg qwk Stavudine, 40 mg bid QNS 2 Good response to polytherapy in naive patient, good compliance Bactrim DS, qd Lamivudine, 150 mg bid QNS 2 Indinavir, 800 mg tid 1.1 mg/L 2 10 Stavudine, 40 mg bid 0.2 mg/L 10 Trough concentration, same day Lamivudine, 150 mg bid 0.05 mg/L 10 Indinavir, 800 mg tid <0.1 mg/L 10 11 <187 189 Azithromycin, 1200 mg qwk Lamivudine, 150 mg bid 1.7 mg/L 1.5 Good response to polytherapy in naive patient, good compliance Bactrim DS, qd Zidovudine, 300 mg bid 1.2 mg/L 1.5 Fluconazole, 200 mg qd Indinavir, 800 mg q8h 3.7 mg/L 1.5 12 279 650 6 Azithromycin, 1200 mg qwk Stavudine, 40 mg bid <LOQ 2 Attempt to rescue from monotherapy treatment failure, unknown compliance Adefovir, 120 mg qd NA Efavirenz, 600 mg qd NA Indinavir, 1200 mg bid <LOQ 2

¹ qd, per day; bid, two times per day; LOQ, limit of quantification; tid, three times per day; q8h, once each 8 h; qwk, per week; QNS, quantity not sufficient; NA, not assayed.

² ??, there is some uncertainty about the patient's ability to comply with the dosing regimen.

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