Clinical Chemistry 47: 797, 2001;
(Clinical Chemistry. 2001;47:797.)
© 2001 American Association for Clinical Chemistry, Inc.
Compiled by David E. Bruns, Editor (dbruns@aacc.org)
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New Features of the On-Line Journal
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If you have not investigated the Journal on-line
(www.clinchem.org), you are missing good things. Two
examples are Data Supplements and eLetters.
Data Supplements allow posting of vast amounts of valuable
and, in some cases, unique information. Some examples:
- Gene sequence data: Last year the Journal posted the
results of large microarray experiments described by Wikman et al.
(1). Subsequent workers have used the data to test new ways
to study complex data sets.
- Reference values: The posting of a full set of data from a
large study of cerebrospinal fluid in pediatric subjects (2)
allows estimation of age- and sex-adjusted reference intervals by use
of whichever statistical technique is preferred.
- Clinical outcomes studies: Extensive clinical data were
provided for >200 (total) patients examined in (separate) studies by
Lo et al. (3) and Ooi et al. (4). The
availability of these data will allow systematic reviewers to perform
statistical analyses that would be otherwise impossible.
eLetters are for rapid Letters to the Editor about
specific papers published in the Journal. We have posted most of these
within hours of their (electronic) submission, often with accompanying
responses from the authors of the published papers. This time to
publication should be compared with the usual time of several months
for traditional Letters to the Editor. The submission of eLetters is
simple: Simply click on "Submit a response to this article" and
follow the straightforward instructions. It takes only a few minutes.
We plan, with Stanford University’s support, to maintain
("archive") the electronic journal on-line for at least 100 years.
(Stanford Library is working on 500 years for Clinical
Chemistry and the other >200 journals at their HighWire Press.)
Content will migrate to new electronic systems (Web or other) as they
emerge. One approach that archived content relies on is a network of
computers at major universities around the globe (including Stanford),
each of which has the full complement of journal content. The system
has a wonderful acronym, LOCKSS, for Lots of Copies Keep Stuff
Safe—just like having (paper) copies of Shakespeare in many libraries.
The new era in journals has, indeed, arrived.
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From Our Intrepid Authors
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Happy New Ear
We trust the resected reviewer...
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The Ever-Amazing Medical Record
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Patient has chest pain if she lies on her left side for over a
year.
The patient refused an autopsy.
The patient has been depressed ever since she began seeing me in 1983.
The patient is tearful and crying constantly. She also appears to be
depressed.
The patient will need disposition, and therefore we will get Dr. XXXX
to dispose of him.
The patient left the hospital feeling much better except for her
original complaint.
—From R. Lederer in the Journal of Court Reporting
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It’s Still Hard to Understand English
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The drug did not affect his affect.
No one is present to present the present, at present.
AACC Meetings
The Post Genome Era: New Targets and New Technologies: The
33rd Annual Oak Ridge Conference, May 4 and 5, 2001, Sheraton
Seattle Hotel and Towers, Seattle, WA. Keynote presentation:
"Genomics, Proteomics, and Systems Approaches to Biology and
Medicine", by Leroy Hood. Topics of other major presentations include
proteomics, bioinformatics, microarrays, SNPs, and new targets for
diagnostics. The third recipient of AACC’s Edwin F. Ullman Award
(sponsored by Dade-Behring), Dr. Carl-Bertil Laurell, will present
"Bench Side Medicine". Information: phone 1-800-892-1400 or
202-857-0717;http://aacc.org/meetings/oakridge/2001/default.stm
.
Cardiac Disease in the New Millennium, an audioconference in
two sessions: "Acute Coronary Syndromes: Spectrum of Care" (April
25, 2001) and "Congestive Heart Failure: What’s the Latest?" (May
2). Topics include: new guidelines for diagnosing cardiac disease; how
the new guidelines will affect reimbursement; the new definition of
myocardial infarction; how these changes will affect the laboratory;
how serum markers can risk stratify cardiac patents; the complexities
of diagnosing congestive heart failure (CHF); and the role of brain
natriuretic peptide (BNP) and pro-BNP. Each session includes 70 min of
presentations and 20 min of question-and-answer, audience polling, and
comprehensive materials. Information: phone 1-800-892-1400 or
202-857-0717;http://aacc.org/meetings/cardiac/default.stm
.
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References
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Wikman FP, Lu M-L, Thykjaer T, Olesen SH, Andersen LD, Cordon-Cardo C, Ørntoft TF. Evaluation of the performance of a p53 sequencing microarray chip using 140 previously sequenced bladder tumor samples. Clin Chem 2000;46:1555-1561.[Abstract/Free Full Text]
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Biou D, Benoist J-F, Nguyen-Thi C, Huong X, Morel P, Marchand M. Cerebrospinal fluid protein concentrations in children: age-related values in patients without disorders of the central nervous system. Clin Chem 2000;46:399-403.[Abstract/Free Full Text]
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Lo YMD, Rainer TH, Chan LYS, Hjelm NM, Cocks RA. Plasma DNA as a prognostic marker in trauma patients. Clin Chem 2000;46:319-323.[Abstract/Free Full Text]
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Ooi DS, Isotalo PA, Veinot JP. Correlation of antemortem serum creatine kinase, creatine kinase-MB, troponin I, and troponin T with cardiac pathology. Clin Chem 2000;46:338-344.[Abstract/Free Full Text]
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