Clinical Chemistry
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Clinical Chemistry 47: 1743-1744, 2001;
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(Clinical Chemistry. 2001;47:1743-1744.)
© 2001 American Association for Clinical Chemistry, Inc.

Letters

RE: Europium Nanoparticles and Time-resolved Fluorescence for Ultrasensitive Detection of Prostate-specific Antigen

David S. Frana and Michael W. Sundberg

aAuthor for correspondence. E-mail stanleydsf{at}aol.com.


To the Editor:

We were intrigued to read of the work reported by Harma et al.(1). Their report provides an excellent summary of the potential advantages and disadvantages of implementing an assay that uses small particles containing highly fluorescent rare earth complexes.

In the 1970s, we evaluated the use of reactive latex particles loaded with rare earth chelates. Europium chelates were of particular interest because of their characteristic strong red emission bands and the extended time course of emission following a pulse of excitation light. Although we ultimately chose to pursue assays using different labels, the work was documented in two US patents (2)(3), which may interest readers.


References

  1. Harma H, Soukka T, Lovgren T. Europium nanoparticles and time-resolved fluorescence for ultrasensitive detection of prostate-specific antigen. Clin Chem 2001;47:561-568.[Abstract/Free Full Text]
  2. Frank DS, Sundberg MW, inventors. Fluorescent labels. US patent 4,259,313, March 31, 1981..
  3. Frank DS, Sundberg MW, inventors. Fluorescent labels comprising rare earth chelates. US patent 4,283,382, August 11, 1981..




This Article
Right arrow Extract Freely available
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Right arrow Articles by Sundberg, M. W.
Related Collections
Right arrow Molecular Diagnostics and Genetics
Right arrow Automation and Analytical Techniques

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