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Clinical Chemistry 47: 1743-1744, 2001;
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(Clinical Chemistry. 2001;47:1743-1744.)
© 2001 American Association for Clinical Chemistry, Inc.

Letters

RE: Europium Nanoparticles and Time-resolved Fluorescence for Ultrasensitive Detection of Prostate-specific Antigen

David S. Frana and Michael W. Sundberg

aAuthor for correspondence. E-mail stanleydsf{at}aol.com.


To the Editor:

We were intrigued to read of the work reported by Harma et al.(1). Their report provides an excellent summary of the potential advantages and disadvantages of implementing an assay that uses small particles containing highly fluorescent rare earth complexes.

In the 1970s, we evaluated the use of reactive latex particles loaded with rare earth chelates. Europium chelates were of particular interest because of their characteristic strong red emission bands and the extended time course of emission following a pulse of excitation light. Although we ultimately chose to pursue assays using different labels, the work was documented in two US patents (2)(3), which may interest readers.


References

  1. Harma H, Soukka T, Lovgren T. Europium nanoparticles and time-resolved fluorescence for ultrasensitive detection of prostate-specific antigen. Clin Chem 2001;47:561-568.[Abstract/Free Full Text]
  2. Frank DS, Sundberg MW, inventors. Fluorescent labels. US patent 4,259,313, March 31, 1981..
  3. Frank DS, Sundberg MW, inventors. Fluorescent labels comprising rare earth chelates. US patent 4,283,382, August 11, 1981..




This Article
Right arrow Extract Freely available
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fran, D. S.
Right arrow Articles by Sundberg, M. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fran, D. S.
Right arrow Articles by Sundberg, M. W.
Related Collections
Right arrow Molecular Diagnostics and Genetics
Right arrow Automation and Analytical Techniques

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