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Clinical Chemistry 49: 2109-a, 2003; 10.1373/clinchem.2003.026906
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(Clinical Chemistry. 2003;49:2109.)
© 2003 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Protein Microarrays: A Literature Survey

Larry J. Kricka1,a, Thomas Joos2 and Paolo Fortina3

1 Department of Pathology, and Laboratory Medicine, 7.103 Founders Pavilion, University of Pennsylvania Medical Center, 3400 Spruce St., Philadelphia, PA 19104
2 NMI Natural and Medical Sciences Institute, at the University of Tuebingen, Markwiesenstrasse 55, 72770 Reutlingen, Germany
3 Center for Translational Medicine, Thomas Jefferson University, 406 Medical Office Bldg., 1100 Walnut St., Philadelphia, PA 19107

aAuthor for correspondence. Fax 215-662-7529; e-mail kricka{at}mail.med.upenn.edu.


To the Editor:

We have previously published literature surveys on microchips, microarrays, and nanotechnology that were compiled by the IFCC Working Group on Nanotechnology (1)(2)(3). The Working Group has now completed a survey on the protein microarray literature. The current survey covers the protein, peptide, and antibody microarray literature up to the middle of 2003.

A protein microarray is a collection of proteins arranged on a planar solid surface (membrane, glass slide, or silicon chip) or immobilized on individual microbeads trapped in the ends of the fibers in a fiber optic bundle, or a collection of coded microbeads in solution (known as a liquid or 3D array). The scope of arrayed protein includes peptides, antigens, antibodies, and allergens. In common with the cDNA and oligonucleotide microarrays, a protein microarray facilitates simultaneous multianalyte assays. These analytical devices are now an important tool in studies to characterize the human and other proteomes and for characterizing protein interactions (e.g., protein–protein and protein–DNA). The literature survey has been divided into four sections: (1) General (books, reviews, editorials); (2) Fabrication (array construction and detection methodologies); (3) Applications (protein identification and quantification, array-based proteomics, protein interactions); and (4) Patents (only US patents listed currently). The database can be accessed at Clinical Chemistry Online at http://www.clinchem.org/content/vol49/issue12/ Other useful resources for general information on protein microarrays and chips are the DNA Microarray (Genome Chip; at www.gene-chips.com) and BioChipNet (www.biochipnet.de) web sites.


Acknowledgments

This compilation is based in part on a survey undertaken by the IFCC Working Group on Nanotechnology, chaired by Dr. Larry J. Kricka. Members of the Working Group are listed in the data supplement that accompanies this letter at Clinical Chemistry Online (http://www.clinchem.org/content/vol49/issue12/).


References

  1. Kricka LJ, Fortina P. Microchips: an all-language literature survey including books and patents. Clin Chem 2002;48:1620-1622.[Free Full Text]
  2. Kricka LJ, Fortina P. Nanotechnology and applications: an all-language literature survey including books and patents. Clin Chem 2002;48:662-665.[Free Full Text]
  3. Kricka LJ, Fortina P. Microarray technology and applications: an all-language literature survey including books and patents. Clin Chem 2001;47:1479-1482.[Free Full Text]



The following articles in journals at HighWire Press have cited this article:


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S. P. FitzGerald, J. V. Lamont, R. I. McConnell, and E. O. Benchikh
Development of a High-Throughput Automated Analyzer Using Biochip Array Technology
Clin. Chem., July 1, 2005; 51(7): 1165 - 1176.
[Abstract] [Full Text] [PDF]

This Article
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Right arrow Alert me to new issues of the journal
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Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (4)
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Google Scholar
Right arrow Articles by Kricka, L. J.
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PubMed
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Right arrow Articles by Kricka, L. J.
Right arrow Articles by Fortina, P.
Related Collections
Right arrow Clinical Immunology
Right arrow Molecular Diagnostics and Genetics
Right arrow Proteomics and Protein Markers
Right arrow Automation and Analytical Techniques

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