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Clinical Chemistry 49: 1227-a, 2003; 10.1373/49.7.1227/-a
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(Clinical Chemistry. 2003;49:1227.)
© 2003 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Reliability of IFCC Method for Lactate Dehydrogenase in Heparin Plasma

Andries J. Bakker

Department of Clinical Chemistry, Klinisch Chemisch Laboratorium, PO Box 850, 8901 BR Leeuwarden, The Netherlands


To the Editor:

I wish to clarify the statement in our report (1) that the Roche lactate dehydrogenase (LD) method "does not provide reliable results" in heparin plasma. The report showed a problem observed only during primary-tube sampling from heparin-plasma tubes from Becton Dickinson. Serum and EDTA plasma caused no problems, suggesting that the method otherwise performed well.

We became aware of data from another laboratory that used Sarstedt sampling tubes and that showed none of the errors we had reported. From additional experiments (manuscript in preparation), we believe that the previously reported errors might be eliminated by adding a predilution step in the analytical sequence. This predilution step now is included in the IFCC method from Roche.


References

  1. Bakker AJ, Mirchi B, Dijkstra JT, Reitsma F, Syperda H, Zijlstra A. IFCC method for lactate dehydrogenase measurement in heparin plasma is unreliable. Clin Chem 2003;49:662-4.[Free Full Text]



The following articles in journals at HighWire Press have cited this article:


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G. Dimeski, T. Badrick, R. Flatman, and B. Ormiston
Roche IFCC Methods for Lactate Dehydrogenase Tested for Duplicate Errors with Greiner and Becton-Dickinson Lithium-Heparin and Greiner Serum Samples
Clin. Chem., December 1, 2004; 50(12): 2391 - 2392.
[Full Text] [PDF]

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 Clin. Chem.Home page
R. R. Miles, R. F. Roberts, A. R. Putnam, and W. L. Roberts
Comparison of Serum and Heparinized Plasma Samples for Measurement of Chemistry Analytes
Clin. Chem., September 1, 2004; 50(9): 1704 - 1706.
[Full Text] [PDF]

This Article
Right arrow Extract Freely available
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the Editor about this paper
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Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (4)
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Google Scholar
Right arrow Articles by Bakker, A. J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Bakker, A. J.
Related Collections
Right arrow Proteomics and Protein Markers
Right arrow Automation and Analytical Techniques

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