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Leikin and Paloucek’s Poisoning and Toxicology Handbook, 3rd Edition. Jerrold Leikin and Frank Paloucek. Hudson, OH: Lexi-Comp, Inc., 2002, 1553 pp., $39.95, softcover. ISBN 1-930598-77-7.

Department of Laboratory Medicine, and Pathology, Mayo Clinic, Rochester, MN 55905

This is a wonderful book! Clinical laboratorians will find it a valuable tool for the laboratory reference book shelf.

This reference text is organized into seven unique sections. The Introduction is a compendium of useful resources such as locations and phone numbers of Poison Control Centers throughout the country, organizations offering information on toxicology, and teratology information services. A 140-page section on Special Topics provides detailed treatment protocols, hospital preparedness guidelines, and a variety of position statements and practice guidelines focused on treatment of toxicities.

The major section of the textbook (1100 pages) presents a detailed review of more than 900 drugs and poisons. Each description contains information on use, mechanism of action, adverse reactions, signs and symptoms of acute overdose, toxicodynamics/kinetics, usual doses, contraindications, dosage forms, overdose/treatment, drug interactions, pregnancy implications, and recent literature citations. These listings are current, including drugs that have been approved by the Food and Drug Administration within the past year. There is a 190-page Appendix containing information on just about every abstract topic one could think of in the field of toxicology, such as lists of drugs that are safe in certain disease states; conversion tables; chemical warfare agents; drug concentration ranges associated with therapeutic doses, overdose, and lethal concentrations; guidelines for animal and human bites; plants; radiation exposure; seizure management; and a wide range of toxidromes. The book concludes with an extensive alphabetical index listing both proprietary and generic names, followed by a Chemical Abstracts Registry (CAS) Index.

This text would be a valuable reference for any clinical laboratory operation as well as the pharmacy and emergency medicine department. The text is complete, up-to-date, and accurate. I recommend it for anyone who might receive a telephone inquiry about a toxin.

This Article Extract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Moyer, T. P. Search for Related Content PubMed Articles by Moyer, T. P.