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Clinical Chemistry 52: 1430a-1431a, 2006; 10.1373/clinchem.2006.069724
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(Clinical Chemistry. 2006;52:1430a-1431.)
© 2006 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Historical Background of the Invention of EIA and ELISA

Stratis Avrameas

Medical School, University of Athens, Department of Pathophysiology, 51 Pratinou St., Athens 11634, Greece, Fax 30-210-724-7187, E-mail avrameasstratis{at}yahoo.fr


To the Editor:

Colleagues have brought to my attention the article "Enzyme Immunoassay (EIA)/Enzyme-Linked Immunosorbent Assay (ELISA)" by R.M. Lequin, recently published in Clinical Chemistry (1).

The assertion made in that article, that EIA/ELISA was first introduced, independently and simultaneously, by 2 scientific research groups, is correct but incomplete. In fact, a 3rd group, our team at the Pasteur Institute, also developed and published in 1971 an enzymo-immunologic method, this one for the measurement of serum IgG, with the aid of immunoadsorbants and enzyme-labeled antigens (2).

Incidentally, we also published in 1971 an immunoenzymatic method for the measurement of cellular immunoglobulins (3), although this method was not a classic (in the strictest sense), quantitative solid-phase immunoassay.


References

  1. Lequin RM. Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA). Clin Chem 2005;51:2415-2418.[Abstract/Free Full Text]
  2. Avrameas S, Guilbert B. [Enzymo-immunological determination of proteins with the aid of immunoadsorbants and enzyme-labeled antigens]. C R Acad Sci Hebd Seances Acad Sci D 1971;273:2705-2707.[Medline] [Order article via Infotrieve]
  3. Avrameas S, Guilbert B. A method for quantitative determination of cellular immunoglobulins by enzyme-labeled antibodies. Eur J Immunol 1971;1:394-396.[Medline] [Order article via Infotrieve]




This Article
Right arrow Extract Freely available
Right arrow Full Text (PDF)
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the Editor about this paper
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Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Avrameas, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Avrameas, S.
Related Collections
Right arrow General Clinical Chemistry
Right arrow Clinical Immunology
Right arrow Pediatric Clinical Chemistry
Right arrow Nutrition
Right arrow History
Right arrow Cancer Diagnostics (since 2002)
Right arrow Proteomics and Protein Markers
Right arrow Lipids, Lipoproteins, and Cardiovascular Risk Factors
Right arrow Drug Monitoring and Toxicology
Right arrow Hematology
Right arrow Endocrinology and Metabolism
Right arrow Automation and Analytical Techniques

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