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Clinical Chemistry 52: 1431, 2006; 10.1373/clinchem.2006.070656
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(Clinical Chemistry. 2006;52:1431.)
© 2006 American Association for Clinical Chemistry, Inc.

Letters to the Editor

The author of the article cited above responds:

Rudolf M. Lequin

Diagnostic Consultancy, Eindhoven, The Netherlands, Fax 31-40-290-8621, E-mail r.m.lequin{at}planet.nl


To the Editor:

Professor Avrameas is indeed correct, and I acknowledge the fact that the cited references should have been mentioned in my historical note (1).

Avrameas’ pioneering work on the use of enzymes rather than radioactive labels was cited twice in that historical note [as references 5 and 6 in (1)]. These cited papers, together with the work of many other pioneers, such as Nakane and Pierce in Los Angeles and Wide and Porath in Uppsala, were presented in the historical note as "building blocks" in the research sequence that led to the development and validation of nonradioactive immunochemical techniques. The application of the enzyme-labeled techniques of Avrameas and colleagues focused on immunocytology and immunohistochemistry.

The historical note focused on the 2 other groups (in Stockholm and Oss) because the intended audience was clinical chemists, not histologists or cytologists. The groups in Stockholm and Oss vigorously expanded on their first findings of ELISA and EIA and applied them to a wide variety of analytes in clinical chemistry/laboratory medicine in the years after their publications in 1971.


References

  1. Lequin RM. Enzyme Immunoassay (EIA)/Enzyme-Linked Immunosorbent Assay (ELISA). Clin Chem 2005;51:2415-2418.[Abstract/Free Full Text]




This Article
Right arrow Extract Freely available
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lequin, R. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Lequin, R. M.
Related Collections
Right arrow History
Right arrow Automation and Analytical Techniques

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