Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 52: 601-623, 2006. First published February 16, 2006; 10.1373/clinchem.2005.061408
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
clinchem.2005.061408v1
52/4/601    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (99)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dalle-Donne, I.
Right arrow Articles by Milzani, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dalle-Donne, I.
Right arrow Articles by Milzani, A.
Related Collections
Right arrow Other Areas of Clinical Chemistry
Right arrow Proteomics and Protein Markers
(Clinical Chemistry. 2006;52:601-623.)
© 2006 American Association for Clinical Chemistry, Inc.

Reviews

Biomarkers of Oxidative Damage in Human Disease

Isabella Dalle-Donne1,a, Ranieri Rossi2, Roberto Colombo1, Daniela Giustarini2 and Aldo Milzani1

1 Department of Biology, University of Milan, Milan, Italy.
2 Department of Neuroscience, University of Siena, Siena, Italy.

aAddress correspondence to this author at: Department of Biology, University of Milan, via Celoria 26, I-20133 Milan, Italy. Fax 39-02-50314781; e-mail quack{at}unimi.it.

Oxidative/nitrosative stress, a pervasive condition of increased amounts of reactive oxygen/nitrogen species, is now recognized to be a prominent feature of many acute and chronic diseases and even of the normal aging process. However, definitive evidence for this association has often been lacking because of recognized shortcomings with biomarkers and/or methods available to assess oxidative stress status in humans. Emphasis is now being placed on biomarkers of oxidative stress, which are objectively measured and evaluated as indicators of normal biological processes, pathogenic processes, or pharmacologic responses to therapeutic intervention. To be a predictor of disease, a biomarker must be validated. Validation criteria include intrinsic qualities such as specificity, sensitivity, degree of inter- and intraindividual variability, and knowledge of the confounding and modifying factors. In addition, characteristics of the sampling and analytical procedures are of relevance, including constraints and noninvasiveness of sampling, stability of potential biomarkers, and the simplicity, sensitivity, specificity, and speed of the analytical method. Here we discuss some of the more commonly used biomarkers of oxidative/nitrosative damage and include selected examples of human studies.




The following articles in journals at HighWire Press have cited this article:


Home page
 Proc. Natl. Acad. Sci. USAHome page
K. R. Atkuri, T. M. Cowan, T. Kwan, A. Ng, L. A. Herzenberg, L. A. Herzenberg, and G. M. Enns
Inherited disorders affecting mitochondrial function are associated with glutathione deficiency and hypocitrullinemia
PNAS, March 10, 2009; 106(10): 3941 - 3945.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
H. Drobiova, M. Thomson, K. Al-Qattan, R. Peltonen-Shalaby, Z. Al-Amin, and M. Ali
Garlic Increases Antioxidant Levels in Diabetic and Hypertensive Rats Determined by a Modified Peroxidase Method
Evid. Based Complement. Altern. Med., February 20, 2009; (2009) nep011v1.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
A. Ledo, A. Arduini, M. A Asensi, J. Sastre, R. Escrig, M. Brugada, M. Aguar, P. Saenz, and M. Vento
Human milk enhances antioxidant defenses against hydroxyl radical aggression in preterm infants
Am. J. Clinical Nutrition, January 1, 2009; 89(1): 210 - 215.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. I. Hashemy and A. Holmgren
Regulation of the Catalytic Activity and Structure of Human Thioredoxin 1 via Oxidation and S-Nitrosylation of Cysteine Residues
J. Biol. Chem., August 8, 2008; 283(32): 21890 - 21898.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
C. Tatone, F. Amicarelli, M. C. Carbone, P. Monteleone, D. Caserta, R. Marci, P. G. Artini, P. Piomboni, and R. Focarelli
Cellular and molecular aspects of ovarian follicle ageing
Hum. Reprod. Update, March 1, 2008; 14(2): 131 - 142.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. R. Morris, J. H. Suh, W. Hagar, S. Larkin, D. A. Bland, M. H. Steinberg, E. P. Vichinsky, M. Shigenaga, B. Ames, F. A. Kuypers, et al.
Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease
Blood, January 1, 2008; 111(1): 402 - 410.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
K. D. Passalacqua, N. H. Bergman, J. Y. Lee, D. H. Sherman, and P. C. Hanna
The Global Transcriptional Responses of Bacillus anthracis Sterne (34F2) and a {Delta}sodA1 Mutant to Paraquat Reveal Metal Ion Homeostasis Imbalances during Endogenous Superoxide Stress
J. Bacteriol., June 1, 2007; 189(11): 3996 - 4013.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. Rossi, I. Dalle-Donne, A. Milzani, and D. Giustarini
Oxidized Forms of Glutathione in Peripheral Blood as Biomarkers of Oxidative Stress
Clin. Chem., July 1, 2006; 52(7): 1406 - 1414.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the American Association for Clinical Chemistry.