Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 52: 1190-1192, 2006. First published March 23, 2006; 10.1373/clinchem.2005.059360
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow 059360.Suppl Data Table 1
Right arrow All Versions of this Article:
clinchem.2005.059360v1
52/6/1190    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Funk, M.
Right arrow Articles by Mannhalter, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Funk, M.
Right arrow Articles by Mannhalter, C.
Related Collections
Right arrow Molecular Diagnostics and Genetics
(Clinical Chemistry. 2006;52:1190-1192.)
© 2006 American Association for Clinical Chemistry, Inc.

Technical Briefs

Factor VII Gene Haplotypes and Risk of Ischemic Stroke

Marion Funk1, Georg Endler1, Wolfgang Lalouschek2, Kety Hsieh1, Martin Schillinger3, Wilfried Lang4 and Christine Mannhalter1,a

1 Institute of Medical and Chemical Laboratory Diagnostics,2 University Clinic of Neurology, and3 Department of Internal Medicine, Division of Angiology, Medical University of Vienna, Vienna, Austria;4 Hospital Barmherzige Brueder, Vienna, Austria;

aaddress correspondence to this author at: Institute of Medical and Chemical Laboratory Diagnostics, Waehringer Guertel 18-20, 1090 Vienna, Austria; fax 43-1-40400-2097, e-mail christine.mannhalter{at}meduniwien.ac.at


Abstract

Background: Coagulation factor VII (FVII) plays an important role in the activation of blood coagulation and clot formation. Recent studies have provided evidence for an association between common polymorphic markers in the FVII gene and plasma FVII concentrations. The 353R>Q sequence variation, and 3 common sequence variations in the promoter of the FVII gene—the 10-bp insertion/deletion at position –323 and the –401G>T and –402G>A sequence variations—are well-known determinants of circulating FVII concentrations.

Methods: To clarify the role of these sequence variations in the pathogenesis of ischemic stroke, we performed a case–control study with 242 patients with ischemic stroke before the age of 60 years and 239 healthy controls.

Results: The –323 insertion/deletion and the 353R>Q and –401G>T sequence variations were in strong linkage disequilibrium, and the resulting haplotypes occurred with equal frequencies in patients and controls. The variant form of FVII (–402G>A) occurred only in combination with the common (wild-type) sequences at all other loci. This haplotype was more frequent in patients than in healthy controls (28% vs 22%). The difference in the prevalence of carriers of this haplotype among patients and controls was statistically significant (P = 0.03; odds ratio = 1.6; 95% confidence interval, 1.1–2.6).

Conclusion: According to our results, the FVII –402A allele seems to increase the risk of early ischemic cerebrovascular events, whereas the 353R>Q, G–401T, and –323ins/del sequence variations, which are in close linkage disequilibrium, apparently do not influence the risk of stroke.




The following articles in journals at HighWire Press have cited this article:


Home page
 J. Biol. Chem.Home page
A. A. Jackson, K. R. Cronin, R. Zachariah, and J. A. Carew
CCAAT/Enhancer-binding Protein-beta Participates in Insulin-responsive Expression of the Factor VII Gene
J. Biol. Chem., October 26, 2007; 282(43): 31156 - 31165.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the American Association for Clinical Chemistry.