HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: clinchem.2005.066217v1 52/7/1318    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Gori, A. M. Articles by Abbate, R. Search for Related Content PubMed PubMed Citation Articles by Gori, A. M. Articles by Abbate, R. Related Collections Hemostasis and Thrombosis Lipids, Lipoproteins, and Cardiovascular Risk Factors

Predictors of Vitamin B₆ and Folate Concentrations in Older Persons: The InCHIANTI Study

¹ Department of Medical and Surgical Critical Care, and³ Multidisciplinary Centre of Research on Food Sciences (G.R.A.), University of Florence, Florence, Italy.
² Centro S. Maria agli Ulivi, Fondazione Don Carlo Gnocchi Onlus IRCCS-Impruneta, Florence, Italy.
⁴ Tuscany Regional Health Agency, Florence, Italy.
⁵ Geriatric Rehabilitation, Azienda Sanitaria di Firenze, Florence, Italy.
⁶ Longitudinal Studies Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD.

^aAddress correspondence to this author at: Department of Medical and Surgical Critical Care, University of Florence, Viale Morgagni, 85, 50134 Florence, Italy. Fax 30-055-794-9418; e-mail annamaria.gori{at}unifi.it.

Background: Low dietary intake and low serum concentrations of vitamin B₆ and/or folate are associated with increased risk of vascular events, possibly because of their association with inflammation, which plays a crucial role in the pathogenesis of cardiovascular diseases.

Methods: Using data from 1320 participants in the population-based InCHIANTI study (586 men and 734 women; median age, 69 years; range, 21–102 years) for whom complete data on folate, vitamin B₆, inflammatory markers, 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T sequence variant, and important covariates were available, we evaluated the association of inflammatory markers with circulating concentrations of vitamin B₆ and folate, independently of dietary vitamin intake, circulating vitamin concentrations, and MTHFR C677T sequence variant.

Results: According to multiple linear regression analysis, C-reactive protein and interleukin-6 receptor were strongly and negatively associated with circulating vitamin B₆ but not with folate concentrations, independent of age, sex, serum creatinine, serum albumin, total energy intake, smoking history, dietary nutrient intake, and circulating homocysteine and vitamin concentrations. Serum folate concentrations were related to MTHFR 677 TT genotype in persons with folate intake in the lowest tertile (<221.2 µg/day). Vitamin C and retinol intakes were strongly and positively associated with serum folate concentrations independent of age, sex, serum creatinine, serum albumin, total energy intake, smoking history, homocysteine plasma concentrations, dietary nutrient intakes, serum vitamin B₆ and vitamin B₁₂ concentrations, and MTHFR C677T sequence variant.

Conclusions: Low serum vitamin B₆, but not serum folate, concentrations are independent correlates of the proinflammatory state, and both are influenced by antioxidant reserves.

The following articles in journals at HighWire Press have cited this article:

				N. Deshpande, E. J. Metter, S. Bandinelli, J. Guralnik, and L. Ferrucci Gait speed under varied challenges and cognitive decline in older persons: a prospective study Age Ageing, September 1, 2009; 38(5): 509 - 514. [Abstract] [Full Text] [PDF]