| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Lipids, Lipoproteins, and Cardiovascular Risk Factors |
1 Health Screening Center, 2
Department of Occupational Medicine, and 3
Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
4 Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Ulsan, Korea.
aAddress correspondence to this author at: Kangbuk Samsung Hospital, 108 Pyung dong, Jongro-Gu, Seoul, Korea 110-746. Fax 82-2-2001-2626; e-mail sh703.yoo{at}samsung.com.
Background: In nonalcoholic fatty liver disease (NAFLD), increased alanine aminotransferase (ALT) concentrations are considered to be a consequence of hepatocyte damage. We performed a prospective study to examine the association between ALT within its reference interval and risk for subsequent development of NAFLD.
Methods: The study cohort comprised 5237 healthy men without diagnosed NAFLD and without increases of either ALT (
35 U/L) or 
-glutamyltransferase (GGT; 40 U/L) above the reference intervals. We assessed alcohol intake via self-reporting (questionnaire) and performed biochemical tests for liver and metabolic function and abdominal ultrasonography. We used the Cox proportional hazards model to calculate the adjusted hazard ratios (aHRs) in the model for NAFLD.
Results: During 13 276.6 person-years of follow-up over a 4-year period, 984 new incident cases of NAFLD developed. We adjusted for age, weight change, body mass index, glucose, blood pressure, triglycerides, HDL cholesterol, smoking, alcohol consumption, regular exercise, homeostasis model assessment of insulin resistance, C-reactive protein, and incident diabetes. Compared with an ALT concentration of <16 U/L, aHR values (95% confidence intervals) for ALT concentrations were 1.53 (1.18–1.98), 1.66 (1.29–2.13), 1.62 (1.26–2.08), and 2.21 (1.73–2.81) for ALT concentrations of 16–18, 19–21, 22–25, and 26–34 U/L, respectively. This relationship remained significant even among normal-weight participants who were still within the reference interval of ALT and GGT at all follow-up examinations.
Conclusions: In apparently healthy, nondiabetic Korean men, increased ALT concentration, even within the reference interval, was an independent predictor of incident NAFLD.
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  L Xu, C-f Xu, C-h Yu, M Miao, and Y-m Li Haemoglobin and non-alcoholic fatty liver disease: further evidence from a population-based study Gut, December 1, 2009; 58(12): 1706 - 1707. [Full Text] [PDF]
|
|
|
|
|
|
Y Chang, S Ryu, E Sung, H-Y Woo, S-I Cho, S-H Yoo, H-Y Ahn, and N-K Choi Weight gain within the normal weight range predicts ultrasonographically detected fatty liver in healthy Korean men Gut, October 1, 2009; 58(10): 1419 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Musso, R. Gambino, G. Pacini, F. De Michieli, and M. Cassader Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver Am. J. Clinical Nutrition, February 1, 2009; 89(2): 558 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. I Alatalo, H. M Koivisto, J. P Hietala, K. S Puukka, R. Bloigu, and O. J Niemela Effect of moderate alcohol consumption on liver enzymes increases with increasing body mass index Am. J. Clinical Nutrition, October 1, 2008; 88(4): 1097 - 1103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Neuschwander-Tetri, A. Unalp, M. H. Creer, and for the Nonalcoholic Steatohepatitis Clinical Rese Influence of Local Reference Populations on Upper Limits of Normal for Serum Alanine Aminotransferase Levels Arch Intern Med, March 24, 2008; 168(6): 663 - 666. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Musso, R. Gambino, S. Bo, B. Uberti, G. Biroli, G. Pagano, and M. Cassader Should Nonalcoholic Fatty Liver Disease Be Included in the Definition of Metabolic Syndrome?: A cross-sectional comparison with Adult Treatment Panel III criteria in nonobese nondiabetic subjects Diabetes Care, March 1, 2008; 31(3): 562 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Musso, R. Gambino, F. De Michieli, G. Biroli, A. Premoli, G. Pagano, S. Bo, M. Durazzo, and M. Cassader Nitrosative stress predicts the presence and severity of nonalcoholic fatty liver at different stages of the development of insulin resistance and metabolic syndrome: possible role of vitamin A intake Am. J. Clinical Nutrition, September 1, 2007; 86(3): 661 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gomez-Ambrosi, V. Catalan, B. Ramirez, A. Rodriguez, I. Colina, C. Silva, F. Rotellar, C. Mugueta, M. J. Gil, J. A. Cienfuegos, et al. Plasma Osteopontin Levels and Expression in Adipose Tissue Are Increased in Obesity J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3719 - 3727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Targher, M. Franchini, G. C. Guidi, M. Muggeo, and G. Lippi Alanine Aminotransferase as an Independent Predictor of Incident Nonalcoholic Fatty Liver Disease Clin. Chem., June 1, 2007; 53(6): 1159 - 1159. [Full Text] [PDF]
|
|
|
|
|
|
Y. Chang, S. Ryu, E. Sung, and Y. Jang Reply to Alanine Aminotransferase as an Independent Predictor of Incident Nonalcoholic Fatty Liver Disease Clin. Chem., June 1, 2007; 53(6): 1159 - 1161. [Full Text] [PDF]
|
|
Read all eLetters
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
