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Clinical Chemistry 53: 1235-1243, 2007. First published May 17, 2007; 10.1373/clinchem.2006.085068
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(Clinical Chemistry. 2007;53:1235-1243.)
© 2007 American Association for Clinical Chemistry, Inc.

Hemostasis and Thrombosis

High Concentrations of Soluble P-Selectin Are Associated with Risk of Venous Thromboembolism and the P-Selectin Thr715 Variant

Cihan Ay1, Lea V. Jungbauer2, Thomas Sailer1, Theres Tengler1, Silvia Koder1, Alexandra Kaider3, Simon Panzer4, Peter Quehenberger2, Ingrid Pabinger1,a and Christine Mannhalter2

1 Division of Haematology and Haemostaseology, Department of Internal Medicine I, 2 Clinical Institute of Medical and Chemical Laboratory Diagnostics, 3 Core Unit for Medical Statistics and Informatics, Section of Clinical Biometrics, and 4 Clinic for Blood Group Serology, Medical University Vienna, Vienna, Austria.

aAddress correspondence to this author at: Division of Haematology and Haemostaseology, Department of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. Fax 43-1-40400-4030; e-mail: ingrid.pabinger{at}meduniwien.ac.at.

Background: The cell adhesion molecule P-selectin has an important role in the pathophysiology of thrombosis. The effect on venous thromboembolism (VTE) of increased circulating concentrations of soluble P-selectin (sP-selectin) and their association with the P-selectin variant Thr715Pro is still uncertain.

Methods: This study was a case-control study of 116 patients with confirmed recurrent VTE and at least 1 event of unprovoked deep venous thrombosis or pulmonary embolism, and 129 age- and sex-matched healthy individuals. We measured sP-selectin by ELISA and P-selectin gene (SELP) variation by genotyping and sampled blood after a mean interval of 2.55 years after the most recent VTE event.

Results: The mean (SD) sP-selectin concentration was higher in patients than in controls: 47.3 (15.0) µg/L vs 36.8 (11.0) µg/L, P <0.001. The unadjusted odds ratio (OR) for sP-selectin >55.1 µg/L, representing the 95th percentile for controls, was 8.5 (95% CI, 3.7–23.3; P <0.001) and increased after adjustment for factor V Leiden, the prothrombin G20210A variant, increased factor VIII, and hyperhomocysteinemia (OR, 10.6; 95% CI, 4.1–31.2; P <0.001). Pro715 carriers were more prevalent among controls than patients (21.7% vs 14.7%). sP-selectin concentrations were lower in this subgroup than in noncarriers: 31.3 (7.9) µg/L vs 44.1 (14.1) µg/L; P <0.001).

Conclusions: Increased sP-selectin concentrations are associated with VTE and genotype status. sP-selectin concentrations are lower in individuals carrying the P-selectin Pro715 variant than in those without this variant.




The following articles in journals at HighWire Press have cited this article:


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C. Ay, R. Simanek, R. Vormittag, D. Dunkler, G. Alguel, S. Koder, G. Kornek, C. Marosi, O. Wagner, C. Zielinski, et al.
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