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Plasma Concentration of Heat Shock Protein 27 and Risk of Cardiovascular Disease: A Prospective, Nested Case-Control Study

¹ Center for Cardiovascular Disease Prevention and the Divisions of ² Preventive Medicine and ³ Cardiology, Brigham and Women’s Hospital, Boston; ⁴ Harvard Medical School, Boston; ⁵ Cardiovascular Division, Brigham and Women’s Hospital and Harvard Medical School, Boston; ⁶ Department of Epidemiology, Harvard School of Public Health, Boston; ⁷ Children’s Hospital Boston; ⁸ Department of Epidemiology & Biostatistics, Erasmus MC, Rotterdam, The Netherlands; ⁹ Leducq Center for Molecular and Genetic Epidemiology; ¹⁰ Donald W. Reynolds Center for Cardiovascular Research; ¹¹ Vascular Research Lab. Fundacion Jimenez Diaz, Autonoma University, Madrid, Spain; ¹² INSERM Unit 698, Cardiovascular Hematology, Bio-Engineering and Remodeling, CHU X-Bichat, Université Paris 7, Paris, France.

^aAddress correspondence to this author at: Department of Epidemiology & Biostatistics, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. Fax +31 10 4089382; e-mail i.kardys{at}erasmusmc.nl.

Background: Heat shock protein 27 (HSP27) has been hypothesized to be a potential biomarker of atherothrombosis. However, no prospective studies have yet been performed to investigate the association between HSP27 plasma concentration and incident cardiovascular events among initially healthy individuals.

Methods: We evaluated plasma concentrations of HSP27 at baseline among 255 initially healthy participants in the Women’s Health Study who subsequently developed myocardial infarction, ischemic stroke, or cardiovascular death during a follow-up period of up to 5.9 years and among an equal number of women matched for age and smoking but who remained free of cardiovascular disease over the same time period.

Results: Overall, HSP27 plasma concentrations were inversely associated with age (Spearman correlation coefficient r = –0.258, P <0.001), but not with other established cardiovascular risk factors. Conditional logistic regression analysis showed no significant association of baseline HSP27 plasma concentration with future cardiovascular disease; the odds ratio for upper vs lower tertile of HSP27 concentration at baseline was 0.99 (95% CI 0.62–1.57, P for trend = 0.99).

Conclusion: In this prospective study of initially healthy women, baseline HSP27 plasma concentration was not associated with incident cardiovascular events.