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Received on September 17, 2003
Accepted on December 8, 2003
Lipids, Lipoproteins, and Cardiovascular Risk Factors |
1 Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA 30341
2 Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341
* To whom correspondence should be addressed. E-mail: eford{at}cdc.gov.
Background: Understanding the distribution of C-reactive protein (CRP) concentration among adult women in the US helps to establish the magnitude of women at increased risk for cardiovascular disease.
Methods: We examined the distribution and correlates of CRP, using data from 2205 women 
20 years of age from the National Health and Nutrition Examination Survey 1999-2000. CRP was measured with a high-sensitivity latex-enhanced turbidimetric assay.
Results: CRP concentration ranged from 0.1 to 296.0 mg/L (median, 2.7 mg/L). After exclusion of women with a CRP concentration >10 mg/L, the median was 2.2 mg/L. Approximately 25.6% of women, representing 
26.6 million women, did not report using hormone replacement therapy and had a CRP concentration >3.0 to 10 mg/L, a category considered to indicate high risk for cardiovascular disease. Multiple linear regression analysis included age, race or ethnicity, education, smoking status, total cholesterol concentration, triglyceride concentration, systolic blood pressure, waist circumference, and concentrations of glucose, insulin, c-peptide, and glycosylated hemoglobin. CRP concentration varied by race or ethnicity (Mexican American > white) and hormone replacement therapy (users > nonusers). In addition, significant and independent associations existed between CRP and waist circumference, total cholesterol and triglyceride concentrations, and systolic blood pressure but not age, smoking status, alcohol use, insulin concentration, glycosylated hemoglobin, and c-peptide concentration.
Conclusion: Large numbers of US women have an increased concentration of CRP.
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