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Received on December 23, 2005
Accepted on April 11, 2006
Endocrinology and Metabolism |
1 Nutrition and Food Science Department-CeRTA, Pharmacy School
2 Department of Internal Medicine, Hospital Clinic, Institut d'Investigacio Biomedica August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain
3 Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona, Spain
4 Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria
* To whom correspondence should be addressed. E-mail: candres{at}ub.edu.
Background: Nutritional biomarkers may be better measures of dietary exposure than self-reported dietary data. We evaluated resveratrol metabolites, potential biomarkers of wine consumption, in humans after moderate consumption of sparkling, white, or red wines.
Methods: We performed 2 randomized, crossover trials and a cohort study. In the first study, 10 healthy men consumed 30 g of ethanol/day as sparkling wine or gin for 28 days. In the second trial, 10 healthy women consumed 20 g of ethanol/day as white or red wine for 28 days. We also evaluated 52 participants in a study on the effects of a Mediterranean diet on primary prevention of cardiovascular disease (the PREDIMED Study). We used liquid chromatography-tandem mass spectrometry to analyze urinary total resveratrol metabolites (TRMs) and predictive values and ROC curve analyses to assess the diagnostic accuracy.
Results: We observed significant increases in TRMs [72.4 (95% confidence interval, 48.5-96.2; P = 0.005), 211.5 (166.6-256.3; P = 0.005), and 560.5 nmol/g creatinine (244.9-876.1; P = 0.005)] after consumption of sparkling, white, or red wine, respectively, but no changes after the washout or gin periods. In the cohort study, the reported daily dose of wine consumption correlated directly with TRMs (r = 0.654; P <0.001). Using a cutoff of 90 nmol/g, we were able to use TRMs to differentiate wine consumers from abstainers with a sensitivity of 72% (60%-84%); and a specificity of 94% (87%-100%).
Conclusions: Resveratrol metabolites in urine may be useful biomarkers of wine intake in epidemiologic and intervention studies.
The following articles in journals at HighWire Press have cited this article:
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  A. Bishayee Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical Trials Cancer Prevention Research, May 1, 2009; 2(5): 409 - 418. [Abstract] [Full Text] [PDF]
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 E. Sacanella, M. Vazquez-Agell, M. P. Mena, E. Antunez, J. Fernandez-Sola, J. M. Nicolas, R. M Lamuela-Raventos, E. Ros, and R. Estruch Down-regulation of adhesion molecules and other inflammatory biomarkers after moderate wine consumption in healthy women: a randomized trial Am. J. Clinical Nutrition, November 1, 2007; 86(5): 1463 - 1469. [Abstract] [Full Text] [PDF]
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 M. Vazquez-Agell, E. Sacanella, E. Tobias, M. Monagas, E. Antunez, R. Zamora-Ros, C. Andres-Lacueva, R. M. Lamuela-Raventos, J. Fernandez-Sola, J. M. Nicolas, et al. Inflammatory Markers of Atherosclerosis Are Decreased after Moderate Consumption of Cava (Sparkling Wine) in Men with Low Cardiovascular Risk J. Nutr., October 1, 2007; 137(10): 2279 - 2284. [Abstract] [Full Text] [PDF]
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 M. Urpi-Sarda, R. Zamora-Ros, R. Lamuela-Raventos, A. Cherubini, O. Jauregui, R. de la Torre, M. I. Covas, R. Estruch, W. Jaeger, and C. Andres-Lacueva HPLC-Tandem Mass Spectrometric Method to Characterize Resveratrol Metabolism in Humans Clin. Chem., February 1, 2007; 53(2): 292 - 299. [Abstract] [Full Text] [PDF]
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