Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 0: clinchem.2006.068247v1, 2006; 10.1373/clinchem.2006.068247
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
clinchem.2006.068247v1
52/8/1460    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Li, M.
Right arrow Articles by Sanderson, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, M.
Right arrow Articles by Sanderson, J. E.

Received on February 4, 2006
Accepted on June 1, 2006

Current Issues in Laboratory Medicine

Repair of Infarcted Myocardium by an Extract of Geum Japonicum with Dual Effects on Angiogenesis and Myogenesis

Ming Li 1, Cheuk Man Yu 1, Lei Cheng 1, Mei Wang 1, Xuemei 1, Ka Ho Lee 2, Tian Wang 1, Yn Tz Sung 3, John E. Sanderson 4*

1 Li Ka Shing Institute of Health Sciences, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
2 Li Ka Shing Institute of Health Sciences, Department of Anatomy, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
3 Li Ka Shing Institute of Health Sciences, Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR
4 Keele University Medical School, Department of Cardiology, The University Hospital of North Staffordshire NHS Trust, City General Hospital, Stoke-on-Trent, United Kingdom

* To whom correspondence should be addressed. E-mail: John.Sanderson{at}uhns.nhs.uk.

Background: It has become apparent recently that cardiac myocytes can divide after myocardial infarction, a circumstance that challenges the orthodoxy that myocytes may not be terminally differentiated. Replacement of the necrosed heart tissue by newly regenerated functional myocardium is a therapeutic ideal, but attempts to reconstitute functional myocardia and coronary vessels have been less successful.

Methods: We isolated 5 compounds that contain fractions of the Chinese herb Geum japonicum, which is endowed with the dual properties that stimulate the processes of angiogenesis and cardiomyogenesis. We investigated these dual properties in both ex vivo and in vivo systems.

Results: We observed that this bioactive fraction displayed favorable dual actions on early angiogenesis and cardiomyogenesis in acute myocardial infarction in an animal model. Our results demonstrated that application of this bioactive fraction showed pronounced effects on limiting infarct size by 35%-45%, stimulating early development of new blood vessels in 24 h, and regenerating myocardium, replacing ~49% of the total infarction volume after 2 weeks. Echocardiographic studies demonstrated marked improvement of left ventricular function within 2 days after infarction, and the improvement was sustained for 1 month and onward.

Conclusions: These properties of this bioactive fraction appear to be entirely novel and represent a new approach for the treatment of ischemic heart disease.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 by the American Association for Clinical Chemistry.