Received on January 4, 2007
Accepted on August 2, 2007

Nutrition

Decreased Serum Retinol Is Associated with Increased Mortality in Renal Transplant Recipients

¹ Department of Clinical Biochemistry, Royal Victoria Hospital, Belfast, Northern Ireland
² Department of Nephrology, Belfast City Hospital, Belfast, Northern Ireland

^* To whom correspondence should be addressed. E-mail: Grainne.Connolly{at}bll.n-i.nhs.uk.

Background: Vitamin A plays a central role in epithelial integrity and immune function. Given the risk of infection after transplantation, adequate vitamin A concentrations may be important in patients with a transplant. We assessed whether there was an association between retinol concentration and all-cause mortality in renal transplant recipients.

Methods: We recruited 379 asymptomatic renal transplant recipients between June 2000 and December 2002. We measured serum retinol at baseline and collected prospective follow-up data at a median of 1739 days.

Results: Retinol was significantly decreased in those renal transplant recipients who had died at follow-up compared with those who were still alive at follow-up. Kaplan–Meier analysis showed that retinol concentration was a significant predictor of mortality. In multivariate Cox regression analysis, decreased retinol concentration remained a statistically significant predictor of all-cause mortality after adjustment for traditional cardiovascular risk factors, high-sensitivity C-reactive protein, and estimated glomerular filtration rate.

Conclusions: Serum retinol concentration is a significant independent predictor of all-cause mortality in renal transplantation patients. Higher retinol concentration might impart a survival advantage via an antiinflammatory or anti-infective mechanism.