The AACC Lectureship Award Address:

Arnold S. Relman

The market for health care: where is the patient?
Clin Chem 1997 43: 2225-2229. [Extract] [Full Text] [PDF]  

Editorials:

David B. Sacks

Implications of the Revised Criteria for Diagnosis and Classification of Diabetes Mellitus
Clin Chem 1997 43: 2230-2232. [Extract] [Full Text] [PDF]  

Reviews:

Laurence A. Cole

Immunoassay of human chorionic gonadotropin, its free subunits, and metabolites
Clin Chem 1997 43: 2233-2243. [Abstract] [Full Text] [PDF]  

Molecular Pathology and Genetics:

Peter Tschentscher, Christoph Wagener, and Michael Neumaier

Sensitive and specific cytokeratin 18 reverse transcription-polymerase chain reaction that excludes amplification of processed pseudogenes from contaminating genomic DNA
Clin Chem 1997 43: 2244-2250. [Abstract] [Full Text] [PDF]  

Judith A. Welsh, Katariina Castrén, and Kirsi H. Vähäkangas

Single-strand conformation polymorphism analysis to detect p53 mutations: characterization and development of controls
Clin Chem 1997 43: 2251-2255. [Abstract] [Full Text] [PDF]  

Ja Won Suh, Seon Hwa Lee, and Bong Chul Chung

GC-MS determination of organic acids with solvent extraction after cation-exchange chromatography
Clin Chem 1997 43: 2256-2261. [Abstract] [Full Text] [PDF]  

Marla J. Lay and Carl T. Wittwer

Real-time fluorescence genotyping of factor V Leiden during rapid-cycle PCR
Clin Chem 1997 43: 2262-2267. [Abstract] [Full Text] [PDF]  

Haiqin Rong, Hong Ji, Ylva Pernow, Ulrika Sjöstedt, and Elisabet Bucht

Quantification of parathyroid hormone-related protein mRNA by competitive PCR and time-resolved lanthanide fluorometry
Clin Chem 1997 43: 2268-2273. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Norito Takamura, Toru Maruyama, and Masaki Otagiri

Effects of uremic toxins and fatty acids on serum protein binding of furosemide: possible mechanism of the binding defect in uremia
Clin Chem 1997 43: 2274-2280. [Abstract] [Full Text] [PDF]  

John T. Bernert, Jr., Wayman E. Turner, James L. Pirkle, Connie S. Sosnoff, James R. Akins, Mary K. Waldrep, Qinghong Ann, Thomas R. Covey, Wanda E. Whitfield, Elaine W. Gunter, Barbara B. Miller, Donald G. Patterson, Jr., Larry L. Needham, W. Harry Hannon, and Eric J. Sampson

Development and validation of sensitive method for determination of serum cotinine in smokers and nonsmokers by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry
Clin Chem 1997 43: 2281-2291. [Abstract] [Full Text] [PDF]  

E. Thomas Everhart, Polly Cheung, Peter Shwonek, Karen Zabel, Eileen C. Tisdale, Peyton Jacob, III, John Mendelson, and Reese T. Jones

Subnanogram-concentration measurement of buprenorphine in human plasma by electron-capture capillary gas chromatography: application to pharmacokinetics of sublingual buprenorphine
Clin Chem 1997 43: 2292-2302. [Abstract] [Full Text] [PDF]  

Chiung-Sheng Hsiung, Joseph D. Andrade, Robert Costa, and K. Owen Ash

Minimizing interferences in the quantitative multielement analysis of trace elements in biological fluids by inductively coupled plasma mass spectrometry
Clin Chem 1997 43: 2303-2311. [Abstract] [Full Text] [PDF]  

Andrea Griesmacher, Günter Weigel, Gernot Seebacher, and Mathias M. Müller

IMP-dehydrogenase inhibition in human lymphocytes and lymphoblasts by mycophenolic acid and mycophenolic acid glucuronide
Clin Chem 1997 43: 2312-2317. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

Jyrki Kivelä, Seppo Parkkila, Abdul Waheed, Anna-Kaisa Parkkila, William S. Sly, and Hannu Rajaniemi

Secretory carbonic anhydrase isoenzyme (CA VI) in human serum
Clin Chem 1997 43: 2318-2322. [Abstract] [Full Text] [PDF]  

Qiu-Ping Qin, Michael Christiansen, Claus Oxvig, Kim Pettersson, Lars Sottrup-Jensen, Claus Koch, and Bent Nørgaard-Pedersen

Double-monoclonal immunofluorometric assays for pregnancy-associated plasma protein A/proeosinophil major basic protein (PAPP-A/proMBP) complex in first-trimester maternal serum screening for Down syndrome
Clin Chem 1997 43: 2323-2332. [Abstract] [Full Text] [PDF]  

Peter J. O'Brien, Yvonne Landt, and Jack H. Ladenson

Differential reactivity of cardiac and skeletal muscle from various species in a cardiac troponin I immunoassay
Clin Chem 1997 43: 2333-2338. [Abstract] [Full Text] [PDF]  

Volker Keim, Niels Teich, Andrea Reich, Fritz Fiedler, and Joachim Mössner

Polyclonal pancreatic elastase assay is superior to monoclonal assay for diagnosis of acute pancreatitis
Clin Chem 1997 43: 2339-2344. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Peter Luppa, Christine Brückner, Ingrid Schwab, Sabine Hauck, Stefan Schmidmayr, Christian Birkmayer, Birgit Paulus, and Hagen Hauptmann

7-Biotinylated testosterone derivatives as tracers for a competitive chemiluminescence immunoassay of testosterone in serum
Clin Chem 1997 43: 2345-2352. [Abstract] [Full Text] [PDF]  

Erik Gerlo and Frans Gorus

Calibration of ion-exchange HPLC measurements of glycohemoglobin: effect on interassay precision
Clin Chem 1997 43: 2353-2357. [Abstract] [Full Text] [PDF]  

Henrik Borg, Per Fernlund, and Göran Sundkvist

Protein tyrosine phosphatase-like protein IA2-antibodies plus glutamic acid decarboxylase 65 antibodies (GADA) indicates autoimmunity as frequently as islet cell antibodies assay in children with recently diagnosed diabetes mellitus
Clin Chem 1997 43: 2358-2363. [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Paul S. Bachorik, Kathleen L. Lovejoy, Margaret D. Carroll, and Clifford L. Johnson

Apolipoprotein B and AI distributions in the United States, 1988–1991: results of the National Health and Nutrition Examination Survey III (NHANES III)
Clin Chem 1997 43: 2364-2378. [Abstract] [Full Text] [PDF]  

Josep Ribalta, Agnes E. LaVille, Josefa Girona, Joan C. Vallvé, and Lluís Masana

Low plasma vitamin A concentrations in familial combined hyperlipidemia
Clin Chem 1997 43: 2379-2383. [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

John C. Thompson, Alan R. Craig, Carol L. Davey, David J. Newman, Michele L. Lonsdale, William J. Bucher, Patrick D. Nagle, and Christopher P. Price

Kinetics and proposed mechanism of the reaction of an immunoinhibition, particle-enhanced immunoassay
Clin Chem 1997 43: 2384-2389. [Abstract] [Full Text] [PDF]  

Frank Frantzen, Kjersti Grimsrud, Dag-Erik Heggli, Arne Ludvig Faaren, Trond Løvli, and Erling Sundrehagen

Glycohemoglobin filter assay for doctors' offices based on boronic acid affinity principle
Clin Chem 1997 43: 2390-2396. [Abstract] [Full Text] [PDF]  

Laboratory Management:

Nathalie Lepage, Nancy McDonald, Louis Dallaire, and Marie Lambert

Age-specific distribution of plasma amino acid concentrations in a healthy pediatric population
Clin Chem 1997 43: 2397-2402. [Abstract] [Full Text] [PDF]  

Hematology:

Michel Guichardant, Chantal Thevenon, Jean Francois Pageaux, and Michel Lagarde

Basal concentrations of free and esterified monohydroxylated fatty acids in human blood platelets
Clin Chem 1997 43: 2403-2407. [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Raymond Gambino, Edouard Desvarieux, Michael Orth, Holly Matan, Tomy Ackattupathil, Elenore Lijoi, Cathy Wimmer, John Bower, and Elaine Gunter

The relation between chemically measured total iron-binding capacity concentrations and immunologically measured transferrin concentrations in human serum
Clin Chem 1997 43: 2408-2412. [Abstract] [Full Text] [PDF]  

Hachiro Yamanishi, Shigeki Kimura, Shigeru Iyama, Yoshihisa Yamaguchi, and Takehiko Yanagihara

Fully automated measurement of total iron-binding capacity in serum
Clin Chem 1997 43: 2413-2417. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Sinikka Makela, Mehrdad Yazdanpanah, Ian Adatia, and Graham Ellis

Disposable Surgical Gloves and Pasteur (Transfer) Pipettes as Potential Sources of Contamination in Nitrite and Nitrate Assays
Clin Chem 1997 43: 2418-2420. [Extract] [Full Text] [PDF]  

Anthony A. M. Ermens, Angelique J. M. Bayens, Anita C. M. van Gemert, and Johannes L. P. van Duijnhoven

Simple Dot-Blot Method Evaluated for Detection of Antibodies against Extractable Nuclear Antigens
Clin Chem 1997 43: 2420-2422. [Extract] [Full Text]  

Tamás Tóth, Ian Findlay, Bálint Nagy, and Zoltán Papp

Accurate Sizing of (CAG)n Repeats Causing Huntington Disease by Fluorescent PCR
Clin Chem 1997 43: 2422-2423. [Extract] [Full Text]  

Bernhard Widner, Ernst R. Werner, Harald Schennach, Helmut Wachter, and Dietmar Fuchs

Simultaneous Measurement of Serum Tryptophan and Kynurenine by HPLC,
Clin Chem 1997 43: 2424-2426. [Extract] [Full Text]  

Gian Carlo Zucchelli, Alessandro Pilo, Maria Rosa Chiesa, Richard Cohen, and Ch. Albert Bizollon

Analytical Performance of Free PSA Immunoassays: Results from an Interlaboratory Survey,
Clin Chem 1997 43: 2426-2428. [Extract] [Full Text]  

Pilar Sotorrío, Aurelia Quirós, and José María Izquierdo

New Immunoelectrochemiluminometric Assay to Measure Serum Thyrotropin,
Clin Chem 1997 43: 2428-2430. [Extract] [Full Text]  

Giuseppe Banfi, Pierangela Parma, and Marina Pontillo

Stability of Tumor Markers CA 19.9, CA 125, and CA 15.3 in Serum Obtained from Plain Tubes and Tubes Containing Thixotropic Gel Separator
Clin Chem 1997 43: 2430-2431. [Extract] [Full Text]  

Douglas R. Linfert, Chunguang Chen, Lijie Ma, Tianjie Lai, and Gregory J. Tsongalis

Internucleosomal DNA Fragmentation in Apoptotic Myocytes
Clin Chem 1997 43: 2431-2434. [Extract] [Full Text]  

Letters to the Editor:

Mauro Panteghini and Franca Pagani

Biological Variation of Myoglobin in Serum
Clin Chem 1997 43: 2435. [Extract] [Full Text] [PDF]  

Koji Yamada, Atsuhito Yagihashi, Sayoko Ishii, Kuniko Tanemura, Takashi Kida, Naoki Watanabe, and Yoshiro Niitsu

Interference with Nephelometric Assay of C-Reactive Protein and Antistreptolysin-O by Monoclonal IgM- from a Myeloma Patient
Clin Chem 1997 43: 2435-2437. [Extract] [Full Text]  

Graham Ellis, Lebe Chang, Bessie Cogionis, Denis Daneman, Steven R. Binder, Graham Ellis, Lebe Chang, Bessie Cogionis, and Denis Daneman

Incomplete Removal of Labile Fraction When Measuring Hemoglobin A_1c with Bio-Rad Variant^® Analyzer • A representative of Bio-Rad Labs. replies: • The authors of the Letter respond:
Clin Chem 1997 43: 2437-2439. [Extract] [Full Text]  

Maurizio Bevilacqua, Tarcisio Vago, Gabriella Baldi, Guido Norbiato, Serge Masson, and Roberto Latini

Analytical Agreement and Clinical Correlates of Plasma Brain Natriuretic Peptide Measured by Three Immunoassays in Patients with Heart Failure
Clin Chem 1997 43: 2439-2440. [Extract] [Full Text]  

Claudio Letizia, Sabrina Cerci, Stefano Subioli, Luigi Scuro, and Giovanni Clemente

Increased Plasma Endothelin-1 After Nicotine Consumption in Nonsmokers
Clin Chem 1997 43: 2440-2441. [Extract] [Full Text]  

Roman Alberty and Dása Albertyová

Biological Variation of Free and Total Carnitine in Serum of Healthy Subjects
Clin Chem 1997 43: 2441-2443. [Extract] [Full Text]  

Book Reviews:

Philip J. Garry

Laboratory Medicine and the Aging Process. Joseph A. Knight. Chicago: ASCP Press, 1996, 420 pp., $45.00, ISBN 0–89189-397–0.
Clin Chem 1997 43: 2444. [Extract] [Full Text] [PDF]  

Obituary:

James C. Boyd and Adelin Albert

Eugene K. Harris, PhD (1927–1997)
Clin Chem 1997 43: 2445-2446. [Extract] [Full Text] [PDF]  

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