Editorials:

R. Andrew Moore

Free PSA as a Percentage of the Total: Where Do We Go from Here?
Clin Chem 1997 43: 1561-1562. [Full Text] [PDF]  

Molecular Pathology and Genetics:

Bryony G. Henderson, Philip R. Wenham, J. Peter Ashby, and Gillian Blundell

Detecting familial defective apolipoprotein B-100: three molecular scanning methods compared
Clin Chem 1997 43: 1630-1634. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

Patricia M. Crofton, Jean C. Wade, Mervyn R. H. Taylor, and Celia V. Holland

Serum concentrations of carboxyl-terminal propeptide of type I procollagen, amino-terminal propeptide of type III procollagen, cross-linked carboxyl-terminal telopeptide of type I collagen, and their interrelationships in schoolchildren
Clin Chem 1997 43: 1577-1581. [Abstract] [Full Text] [PDF]  

Susan J. Thorpe, Dawn Walker, Paolo Arosio, Alan Heath, James D. Cook, and Mark Worwood

International collaborative study to evaluate a recombinant L ferritin preparation as an International Standard
Clin Chem 1997 43: 1582-1587. [Abstract] [Full Text] [PDF]  

Ralf Junker, Burkhard Brandt, Christian Zechel, and Gerd Assmann

Comparison of prostate-specific antigen (PSA) measured by four combinations of free PSA and total PSA assays
Clin Chem 1997 43: 1588-1594. [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Matthias Nauck, Winfried März, Jochen Jarausch, Christa Cobbaert, Anja Sägers, Dirk Bernard, Joris Delanghe, Gunter Honauer, Paul Lehmann, Evelyn Oestrich, Arnold von Eckardstein, Stephan Walch, Heinrich Wieland, and Gerd Assmann

Multicenter evaluation of a homogeneous assay for HDL-cholesterol without sample pretreatment
Clin Chem 1997 43: 1622-1629. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Hassan M. E. Azzazy, Show-Hong Duh, Andrew Maturen, Elisabeth Schaller, Leslie Shaw, Robert Grimaldi, Gloria Shock, and Robert H. Christenson

Multicenter study of Abbott AxSYM^® Digoxin II assay and comparison with 6 methods for susceptibility to digoxin-like immunoreactive factors
Clin Chem 1997 43: 1635-1640. [Abstract] [Full Text] [PDF]  

Hematology:

Pauli Suominen, Kari Punnonen, Allan Rajamäki, and Kerttu Irjala

Evaluation of new immunoenzymometric assay for measuring soluble transferrin receptor to detect iron deficiency in anemic patients
Clin Chem 1997 43: 1641-1646. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Kazimierz Wróbel, Katarzyna Wróbel, Ma. Eugenia Garay-Sevilla, Laura Eugenia Nava, and Juan Manuel Malacara

Novel analytical approach to monitoring advanced glycosylation end products in human serum with on-line spectrophotometric and spectrofluorometric detection in a flow system
Clin Chem 1997 43: 1563-1569. [Abstract] [Full Text] [PDF]  

Hsin-Shan J. Ju, Sunny Leung, Bradley Brown, Matthew A. Stringer, Scott Leigh, Christy Scherrer, Karen Shepard, Dean Jenkins, Jane Knudsen, and Robert Cannon

Comparison of analytical performance and biological variability of three bone resorption assays
Clin Chem 1997 43: 1570-1576. [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Nadja N. Rehak, Stacey A. Cecco, Julie E. Niemela, and Ronald J. Elin

Thiocyanate in smokers interferes with the Nova magnesium ion-selective electrode
Clin Chem 1997 43: 1595-1600. [Abstract] [Full Text] [PDF]  

Ann Lévesque, Marc Letellier, Paul W. Dillon, and Andrew Grant

Analytical performance of Bayer Immuno 1^TM estradiol and progesterone assays
Clin Chem 1997 43: 1601-1609. [Abstract] [Full Text] [PDF]  

Laboratory Management:

Sharon S. Ehrmeyer and Ronald H. Laessig

Application of the Department of Health and Human Services proposed waived status requirements for in vitro diagnostic testing devices: case study
Clin Chem 1997 43: 1610-1617. [Abstract] [Full Text] [PDF]  

George A. Green, IV, R. Neill Carey, James O. Westgard, Tami Carten, LeeAnn Shablesky, Daniel Achord, Eileen Page, and Anh Van Le

Quality control for qualitative assays: quantitative QC procedure designed to assure analytical quality required for an ELISA of hepatitis B surface antigen
Clin Chem 1997 43: 1618-1621. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Khim Kuo, Rachel Still, Sara Cale, and Ian McDowell

Standardization (External and Internal) of HPLC Assay for Plasma Homocysteine
Clin Chem 1997 43: 1653-1655. [Full Text] [PDF]  

N. R. Badcock, G. D. Zoanetti, and E. S. Martin

Nonchromatographic Assay for Malondialdehyde–Thiobarbituric Acid Adduct with HPLC Equivalence
Clin Chem 1997 43: 1655-1657. [Full Text]  

Ariella Zivelin, Nurit Rosenberg, Hava Peretz, Yonit Amit, Nurit Kornbrot, and Uri Seligsohn

Improved Method for Genotyping Apolipoprotein E Polymorphisms by a PCR-Based Assay Simultaneously Utilizing Two Distinct Restriction Enzymes
Clin Chem 1997 43: 1657-1659. [Full Text]  

Jeri D. Ropero-Miller, Diana Garside, and Bruce A. Goldberger

Automated On-Line Hydrolysis of Benzodiazepines Improves Sensitivity of Urine Screening by a Homogeneous Enzyme Immunoassay
Clin Chem 1997 43: 1659-1660. [Full Text]  

Wen-Shen Wu and Jin-Lian Tsai

Analysis of Cyanine Dye-Labeled PCR Product and Restriction Fragments by Capillary Electrophoresis and Laser-Induced Fluorescence
Clin Chem 1997 43: 1660-1663. [Full Text]  

Jean-Claude Souberbielle, Delphine Marque, Philippe Bonnet, Patricia Herviaux, and Charles Sachs

Simple Method to Evaluate Specificity of Osteocalcin Immunoassays
Clin Chem 1997 43: 1663-1665. [Full Text]  

Joris Delanghe, Hilde Vlaminck, Dirk Bernard, Eddy Robberecht, Marleen Praet, Marc De Buyzere, Jozef Quatacker, Nadine Van Roy, and Johan Van Duynslaegher

Absence of Serum Alanine Aminotransferase Activity in a Neonate
Clin Chem 1997 43: 1665-1667. [Full Text]  

Stephen I. Fisher, Jo A. Haga, Silvia M. Castleberry, Robert B. Hall, and William C. Thompson

Validation of an Automated HPLC Method for Quantification of Hemoglobin S
Clin Chem 1997 43: 1667-1669. [Full Text]  

History:

Henry Curme and Royden N. Rand

Early history of Eastman Kodak Ektachem slides and instrumentation
Clin Chem 1997 43: 1647-1652. [Full Text] [PDF]  

Letters to the Editor:

Martin Crook, Keith Preston, and Ian Lancaster

Serum Prostatic Specific-Antigen Concentrations in Acute Myocardial Infarction
Clin Chem 1997 43: 1670. [Full Text] [PDF]  

Wolfgang Withold, Henning W. Woitge, and Markus J. Seibel

More on Total and Bone-Specific Alkaline Phosphatase • Authors of the article referred to respond:
Clin Chem 1997 43: 1670-1671. [Full Text]  

John McHale

Thiocyanate Interference with Nova's Ionized Magnesium Electrode
Clin Chem 1997 43: 1671-1672. [Full Text]  

Agostino Ognibene, Laura Pala, Gianni Messeri, Carlo Maria Rotella, and Piero Berti

Relations between Intestinal Alkaline Phosphatase Activity and Insulin Secretion in Obese Patients
Clin Chem 1997 43: 1672-1673. [Full Text]  

Book Reviews:

Deanna Klosinski

Quality Assurance Activities for Stat Laboratories. Joseph R. Bailey and Rita R. Miller. Washington, DC: AACC Press, 1996, 220 pp., $60.00. Three-ring binder. ISBN 0-915274-81-7.
Clin Chem 1997 43: 1674. [Full Text] [PDF]  

Jean Joseph

The Laboratory Test Handbook with Key Word Index, 4th ed. David S. Jacobs, Wayne R. DeMott, Harold J. Grady, Rebecca T. Horvat, Douglas W. Huestis, and Bernard L. Kasten, Jr., eds. Hudson, OH: Lexi-Comp, 1996, 823 pp., $54.75. ISBN 0-916589-36-6.
Clin Chem 1997 43: 1674-1675. [Full Text]  

Oak Ridge Conference:

Laurence M. Demers

Introduction
Clin Chem 1997 43: 1677. [Full Text] [PDF]  

Rogier M. Bertina

Factor V Leiden and other coagulation factor mutations affecting thrombotic risk
Clin Chem 1997 43: 1678-1683. [Abstract] [Full Text] [PDF]  

George J. Despotis, J. Heinrich Joist, and Lawrence T. Goodnough

Monitoring of hemostasis in cardiac surgical patients: impact of point-of-care testing on blood loss and transfusion outcomes
Clin Chem 1997 43: 1684-1696. [Abstract] [Full Text] [PDF]  

Bruce J. Oberhardt, Patrick D. Mize, and Cynthia G. Pritchard

Point-of-care fibrinolytic tests: the other side of blood coagulation
Clin Chem 1997 43: 1697-1702. [Abstract] [Full Text] [PDF]  

James Zehnder, Reuel Van Atta, Carol Jones, Howard Sussman, and Michael Wood

Cross-linking hybridization assay for direct detection of factor V Leiden mutation
Clin Chem 1997 43: 1703-1708. [Abstract] [Full Text] [PDF]  

Alain Truchaud, Tanguy Le Neel, Hugues Brochard, Sophie Malvaux, Marine Moyon, and Murielle Cazaubiel

New tools for laboratory design and management
Clin Chem 1997 43: 1709-1715. [Abstract] [Full Text] [PDF]  

Paul E. Wilson

Coagulation monitor based on serum migration through absorbent materials
Clin Chem 1997 43: 1716-1718. [Abstract] [Full Text] [PDF]  

Francesco Dati, Gerd Hafner, Hilde Erbes, Winfried Prellwitz, Michael Kraus, Frank Niemann, Michael Noah, and Carola Wagner

ProC^® Global: the first functional screening assay for the complete protein C pathway
Clin Chem 1997 43: 1719-1723. [Abstract] [Full Text] [PDF]  

Mitchell G. Scott, Dennis F. Kucik, Lawrence T. Goodnough, and Terri G. Monk

Blood substitutes: evolution and future applications
Clin Chem 1997 43: 1724-1731. [Abstract] [Full Text] [PDF]  

Zhongmin Ma, Terri G. Monk, Lawrence T. Goodnough, Adrain McClellan, Maria Gawryl, Terri Clark, Paulo Moreira, Peter E. Keipert, and Mitchell G. Scott

Effect of hemoglobin- and Perflubron-based oxygen carriers on common clinical laboratory tests
Clin Chem 1997 43: 1732-1737. [Abstract] [Full Text] [PDF]  

Arlene C. Y. Ali, Chrystina C. Mihas, and Janet A. Campbell

Interferences of o-raffinose cross-linked hemoglobin in three methods for serum creatinine
Clin Chem 1997 43: 1738-1743. [Abstract] [Full Text] [PDF]  

Demetra D. Callas, Terri L. Clark, Paulo L. Moreira, Cara Lansden, Maria S. Gawryl, Stephen Kahn, and Edward W. Bermes, Jr.

In vitro effects of a novel hemoglobin-based oxygen carrier on routine chemistry, therapeutic drug, coagulation, hematology, and blood bank assays
Clin Chem 1997 43: 1744-1748. [Abstract] [Full Text] [PDF]  

R. Jerrold Fulton, Ralph L. McDade, Perry L. Smith, Laura J. Kienker, and John R. Kettman, Jr.

Advanced multiplexed analysis with the FlowMetrix^TM system
Clin Chem 1997 43: 1749-1756. [Abstract] [Full Text] [PDF]  

Bernard H. Schneider, John G. Edwards, and Nile F. Hartman

Hartman interferometer: versatile integrated optic sensor for label-free, real-time quantification of nucleic acids, proteins, and pathogens
Clin Chem 1997 43: 1757-1763. [Abstract] [Full Text] [PDF]  

Michael J. Benecky, Diane R. Post, Susan M. Schmitt, and Manish S. Kochar

Detection of hepatitis B surface antigen in whole blood by coupled particle light scattering (Copalis^TM)
Clin Chem 1997 43: 1764-1770. [Abstract] [Full Text] [PDF]  

Dennis J. O'Kane, Thomas A. Ebert, Brenda J. Hallaway, Steven G. Roberts, Abul K. M. J. Bhuiyan, and Kathleen S. Tenner

A laboratorian's perspective on evaluation and implementation of new laboratory tests
Clin Chem 1997 43: 1771-1780. [Abstract] [Full Text] [PDF]  

Abstracts of Oak Ridge Posters:

Alexander Haliassos, Helen Melita-Manolis, Despina Aggelaki, Despina Tassi, and George Terzoglou

Use of Anti-Xa Activity as a Marker for Heparin-Induced Bleeding in Patients with APTT >180 s
Clin Chem 1997 43: 1781-1782. [Full Text] [PDF]  

R. C. Gosselin, E. Larkin, J. T. Owings, and P. Coehlo

CryoSeal^TM System, a New Device for Generating Cryoprecipitate from Plasma
Clin Chem 1997 43: 1782-1783. [Full Text]  

Robert C. Gosselin, John T. Owings, Edward Larkin, and Janis Cannon

Summary Evaluation of the Sysmex CA-6000 Coagulation Analyzer,
Clin Chem 1997 43: 1783-1785. [Full Text]  

R. C. Gosselin, J. T. Owings, E. Larkin, R. H. White, R. Hutchinson, and J. Branch

Monitoring Oral Anticoagulant Therapy with Point-of-Care Devices: Correlations and Caveats.
Clin Chem 1997 43: 1785-1786. [Full Text]  

Debra A. Hoppensteadt, Steven Kahn, and Jawed Fareed

Factor X Values as a Means to Assess the Extent of Oral Anticoagulation in Patients Receiving Antithrombin Drugs
Clin Chem 1997 43: 1786-1788. [Full Text]  

Conan K. N. Li, Thomas J. Hoffmann, Pei-Ying Hsieh, Suneil Malik, and William Watson

Xylum CSA^®: Automated System for Assessing Hemostasis in Simulated Vascular Flow
Clin Chem 1997 43: 1788-1790. [Full Text]  

Paulo L. Moreira, Cara C. Lansden, Terri L. Clark, and Maria S. Gawryl

Effect of Hemopure® on the Performance of Ektachem and Hitachi Clinical Analyzers
Clin Chem 1997 43: 1790-1792. [Full Text]  

Paulo L. Moreira, Cara C. Lansden, Terri L. Clark, and Maria S. Gawryl

Effect of Hemopure^® on Prothrombin Time and Activated Partial Thromboplastin Time on Seven Coagulation Analyzers,
Clin Chem 1997 43: 1792. [Full Text]  

Laszlo Sarkozi, Ellis Jacobs, Terri Clark, Maria S. Gawryl, and Elkin Simson

Effect of Hemoglobin-Based Oxygen Carrier-201 on Common Chemistry Laboratory Procedures
Clin Chem 1997 43: 1792-1794. [Full Text]  

Arlene C. Y. Ali and Janet A. Campbell

Interference of o-Raffinose Cross-Linked Hemoglobin with Routine Hitachi 717 Assays
Clin Chem 1997 43: 1794-1796. [Full Text]  

Cynthia M. Balion, Patricia A. Champagne, and Arlene C. Y. Ali

Evaluation of HemogloBind^TM for Removal of o-Raffinose Cross-Linked Hemoglobin (Hemolink^TM) from Serum
Clin Chem 1997 43: 1796-1798. [Full Text]  

Amin A. Mohammad, Anthony O. Okorodudu, Michael G. Bissell, Pat Dow, Gregg Reger, Annette Meier, Phil Guodagno, and John R. Petersen

Clinical Application of Capillary Isoelectric Focusing on Fused Silica Capillary for Determination of Hemoglobin Variants
Clin Chem 1997 43: 1798-1799. [Full Text]  

Rodger F. Gordon and Ralph L. McDade

Multiplexed Quantification of Human IgG, IgA, and IgM with the FlowMetrix^TM System,
Clin Chem 1997 43: 1799-1801. [Full Text]  

Lokinendi V. Rao, John R. Petersen, Michael G. Bissell, Anthony O. Okorodudu, and Amin A. Mohammad

Specific Determination of Urinary Free Cortisol by Solid-Phase Microparticle Extraction Capillary Electrophoresis with Fused Silica Capillaries
Clin Chem 1997 43: 1801-1803. [Full Text]  

Kirsten C. Kempe, Lori I. Czeschin, Kathryn H. Yates, Susan M. Deuser, and Mitchell G. Scott

A Hospital System Glucose Meter That Produces Plasma-Equivalent Values from Capillary, Venous, and Arterial Blood
Clin Chem 1997 43: 1803-1804. [Full Text]  

Paul A. D'Orazio, Thomas C. Maley, Robert R. McCaffrey, Andy C. Chan, Donna Orvedahl, Joe Foos, David Blake, Sue Degnan, John Benco, Chris Murphy, Peter G. Edelman, and Hans Ludi

Planar (Bio)Sensors for Critical Care Diagnostics
Clin Chem 1997 43: 1804-1805. [Full Text]  

Saeed A. Jortani, Daniel Trepanier, Randall W. Yatscoff, and Roland Valdes, Jr.

Convergence of Three Methods to Resolve Discrepant Immunoassay Digitoxin Results
Clin Chem 1997 43: 1805-1808. [Full Text]  

The Clinical Chemist:

Compiled by David E. Bruns, Editor (dbruns@aacc.org)
Clin Chem 1997 43: 1676. [Full Text] [PDF]  

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