Editorials:

Thomas P. Moyer, David N. Nixon, and K. Owen Ash

Filter Paper Lead Testing
Clin Chem 1999 45: 2055-2056. [Full Text] [PDF]  

Charles P. Cartwright

Synthetic Viral Particles Promise To Be Valuable in the Standardization of Molecular Diagnostic Assays for Hepatitis C Virus
Clin Chem 1999 45: 2057-2059. [Full Text] [PDF]  

Reviews:

Robert F. Labbé, Hendrik J. Vreman, and David K. Stevenson

Zinc Protoporphyrin: A Metabolite with a Mission
Clin Chem 1999 45: 2060-2072. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Christa Bräutigam, Gerry C.H. Steenbergen-Spanjers, Georg F. Hoffmann, Carlo Dionisi-Vici, Lambert P.W.J. van den Heuvel, Jan A.M. Smeitink, and Ron A. Wevers

Biochemical and Molecular Genetic Characteristics of the Severe Form of Tyrosine Hydroxylase Deficiency
Clin Chem 1999 45: 2073-2078. [Abstract] [Full Text] [PDF]  

Cindy R. WalkerPeach, Matthew Winkler, Dwight B. DuBois, and Brittan L. Pasloske

Ribonuclease-resistant RNA Controls (Armored RNA) for Reverse Transcription-PCR, Branched DNA, and Genotyping Assays for Hepatitis C Virus
Clin Chem 1999 45: 2079-2085. [Abstract] [Full Text] [PDF]  

Tomás Adam, David Friedecky, Lynette D. Fairbanks, and Petr Barták

Capillary Electrophoresis for Detection of Inherited Disorders of Purine and Pyrimidine Metabolism
Clin Chem 1999 45: 2086-2093. [Abstract] [Full Text] [PDF]  

Nicolas von Ahsen, Michael Oellerich, Victor William Armstrong, and Ekkehard Schütz

Application of a Thermodynamic Nearest-Neighbor Model to Estimate Nucleic Acid Stability and Optimize Probe Design: Prediction of Melting Points of Multiple Mutations of Apolipoprotein B-3500 and Factor V with a Hybridization Probe Genotyping Assay on the LightCycler
Clin Chem 1999 45: 2094-2101. [Abstract] [Full Text] [PDF]  

Anne Romstad, Per Guldberg, Nenad Blau, and Flemming Güttler

Single-Step Mutation Scanning of the 6-Pyruvoyltetrahydropterin Synthase Gene in Patients with Hyperphenylalaninemia
Clin Chem 1999 45: 2102-2108. [Abstract] [Full Text] [PDF]  

Laurence A. Cole, Shohreh Shahabi, Utku A. Oz, Ray O. Bahado-Singh, and Maurice J. Mahoney

Hyperglycosylated Human Chorionic Gonadotropin (Invasive Trophoblast Antigen) Immunoassay: A New Basis for Gestational Down Syndrome Screening
Clin Chem 1999 45: 2109-2119. [Abstract] [Full Text] [PDF]  

Wolfgang T. Hofgärtner, Andreas F.R. Hühmer, James P. Landers, and Jeffrey A. Kant

Rapid Diagnosis of Herpes Simplex Encephalitis Using Microchip Electrophoresis of PCR Products
Clin Chem 1999 45: 2120-2128. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

Vincent Ricchiuti and Fred S. Apple

RNA Expression of Cardiac Troponin T Isoforms in Diseased Human Skeletal Muscle
Clin Chem 1999 45: 2129-2135. [Abstract] [Full Text] [PDF]  

Nader Rifai, Russell P. Tracy, and Paul M. Ridker

Clinical Efficacy of an Automated High-Sensitivity C-Reactive Protein Assay
Clin Chem 1999 45: 2136-2141. [Abstract] [Full Text] [PDF]  

Miklós Sárdy, Uwe Odenthal, Sarolta Kárpáti, Mats Paulsson, and Neil Smyth

Recombinant Human Tissue Transglutaminase ELISA for the Diagnosis of Gluten-sensitive Enteropathy
Clin Chem 1999 45: 2142-2149. [Abstract] [Full Text] [PDF]  

Yuri R. Nakasato, Anthony J. Janckila, Jussi M. Halleen, H. Kalervo Vaananen, Stephanie P. Walton, and Lung T. Yam

Clinical Significance of Immunoassays for Type-5 Tartrate-resistant Acid Phosphatase
Clin Chem 1999 45: 2150-2157. [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Yuzo Kayamori, Hiroyuki Hatsuyama, Tadayoshi Tsujioka, Masato Nasu, and Yoshiaki Katayama

Endpoint Colorimetric Method for Assaying Total Cholesterol in Serum with Cholesterol Dehydrogenase
Clin Chem 1999 45: 2158-2163. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Tapani Tuomi, Tom Johnsson, and Kari Reijula

Analysis of Nicotine, 3-Hydroxycotinine, Cotinine, and Caffeine in Urine of Passive Smokers by HPLC-Tandem Mass Spectrometry
Clin Chem 1999 45: 2164-2172. [Abstract] [Full Text] [PDF]  

Stefan W. Toennes and Hans H. Maurer

Efficient Cleavage of Conjugates of Drugs or Poisons by Immobilized ß-Glucuronidase and Arylsulfatase in Columns
Clin Chem 1999 45: 2173-2182. [Abstract] [Full Text] [PDF]  

Britt L. Soderberg, Ewa T. Sicinska, Emily Blodget, Joanne E. Cluette-Brown, Paolo M. Suter, Theresa Schuppisser, Wilhem Vetter, and Michael Laposata

Preanalytical Variables Affecting the Quantification of Fatty Acid Ethyl Esters in Plasma and Serum Samples
Clin Chem 1999 45: 2183-2190. [Abstract] [Full Text] [PDF]  

Hematology:

Anne C. Looker, Mark Loyevsky, and Victor R. Gordeuk

Increased Serum Transferrin Saturation Is Associated with Lower Serum Transferrin Receptor Concentration
Clin Chem 1999 45: 2191-2199. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Jurgen C. de Graaff, Geesje J. Hemmes, Taco Bruin, Dirk T. Ubbink, Robert P.J. Michels, Michael J.H.M. Jacobs, and Gerard T.B. Sanders

Influence of Repetitive Finger Puncturing on Skin Perfusion and Capillary Blood Analysis in Patients with Diabetes Mellitus
Clin Chem 1999 45: 2200-2206. [Abstract] [Full Text] [PDF]  

Brian Rafferty and Rose Gaines Das

Comparison of Pituitary and Recombinant Human Thyroid-stimulating Hormone (rhTSH) in a Multicenter Collaborative Study: Establishment of the First World Health Organization Reference Reagent for rhTSH
Clin Chem 1999 45: 2207-2215. [Abstract] [Full Text] [PDF]  

Julie Wassell, Paul Reed, John Kane, and Cyril Weinkove

Freedom from Drug Interference in New Immunoassays for Urinary Catecholamines and Metanephrines
Clin Chem 1999 45: 2216-2223. [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Adriana de Graaf-Hess, Frans Trijbels, and Henk Blom

New Method for Determining Cystine in Leukocytes and Fibroblasts
Clin Chem 1999 45: 2224-2228. [Abstract] [Full Text] [PDF]  

Laboratory Management:

Noel V. Stanton, Jane M. Maney, and Robert Jones

Evaluation of Filter Paper Blood Lead Methods: Results of a Pilot Proficiency Testing Program
Clin Chem 1999 45: 2229-2235. [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Christine M. Pfeiffer, S. Jay Smith, Dayton T. Miller, and Elaine W. Gunter

Comparison of Serum and Plasma Methylmalonic Acid Measurements in 13 Laboratories: An International Study
Clin Chem 1999 45: 2236-2242. [Abstract] [Full Text] [PDF]  

Thierry Le Bricon, Eric Thervet, Mourad Benlakehal, Bernard Bousquet, Christophe Legendre, and Daniele Erlich

Changes in Plasma Cystatin C after Renal Transplantation and Acute Rejection in Adults
Clin Chem 1999 45: 2243-2249. [Abstract] [Full Text] [PDF]  

Case Conference:

Corinne R. Fantz, Samuel Dagogo-Jack, Jack H. Ladenson, and Ann M. Gronowski

Thyroid Function during Pregnancy
Clin Chem 1999 45: 2250-2258. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Cristina Ruiz, Felicia Lamm, and P. Suzanne Hart

Turner Syndrome and Multiple-Marker Screening
Clin Chem 1999 45: 2259-2261. [Full Text] [PDF]  

Bill E. Cham, Jeffery L. Smith, and David M. Colquhoun

What Happens to Vitamin K₁ in Serum after Bone Fracture?
Clin Chem 1999 45: 2261-2263. [Full Text] [PDF]  

Ferdinando Mannello, Manuela Malatesta, Maurizio Sebastiani, Serafina Battistelli, and Giancarlo Gazzanelli

Molecular Forms and Ultrastructural Localization of Prostate-specific Antigen in Nipple Aspirate Fluids,
Clin Chem 1999 45: 2263-2266. [Full Text] [PDF]  

Pradip Datta, Kimberley Foster, and Amitava Dasgupta

Comparison of Immunoreactivity of Five Human Cardiac Troponin I Assays toward Free and Complexed Forms of the Antigen: Implications for Assay Discordance
Clin Chem 1999 45: 2266-2269. [Full Text] [PDF]  

Manou R. Batstra, Arianne van Driel, Jacob S. Petersen, Cees A. van Donselaar, Maarten J. van Tol, G. Jan Bruining, Diederick E. Grobbee, Thomas Dyrberg, and Henk-Jan Aanstoot

Glutamic Acid Decarboxylase Antibodies in Screening for Autoimmune Diabetes: Influence of Comorbidity, Age, and Sex on Specificity and Threshold Values
Clin Chem 1999 45: 2269-2272. [Full Text] [PDF]  

Mercè Garcia-Barceló, Lok-Yee Chow, Helen Fung Kum Chiu, Yun Kowk Wing, Dominic Tak Shing Lee, Kwok Lim Lam, and Mary Miu Yee Waye

Frequencies of Defective CYP2C19 Alleles in a Hong Kong Chinese Population: Detection of the Rare Allele CYP2C19*4
Clin Chem 1999 45: 2273-2274. [Full Text] [PDF]  

Maja Bollhalder, Catherine Mura, Olfert Landt, and Friedrich E. Maly

LightCycler PCR Assay for Simultaneous Detection of the H63D and S65C Mutations in the HFE Hemochromatosis Gene Based on Opposite Melting Temperature Shifts
Clin Chem 1999 45: 2275-2278. [Full Text] [PDF]  

Paul Salm, Paul J. Taylor, and Peter I. Pillans

Analytical Performance of Microparticle Enzyme Immunoassay and HPLC-Tandem Mass Spectrometry in the Determination of Sirolimus in Whole Blood
Clin Chem 1999 45: 2278-2280. [Full Text] [PDF]  

Yoshitaka Morishita, Yoshitsugu Iinuma, Nobuo Nakashima, Akira Kadota, Akira Miike, and Toshio Tadano

Enzymatic Assay of Calcium in Serum with Phospholipase D
Clin Chem 1999 45: 2280-2283. [Full Text] [PDF]  

Paul S. Horn, Amadeo J. Pesce, and Bradley E. Copeland

Reference Interval Computation Using Robust vs Parametric and Nonparametric Analyses
Clin Chem 1999 45: 2284-2285. [Full Text] [PDF]  

Jane Bolton, Jane Sanders, Yasuo Oda, Ceri Chapman, Reiko Konno, Jadwiga Furmaniak, and Bernard Rees Smith

Measurement of Thyroid-stimulating Hormone Receptor Autoantibodies by ELISA
Clin Chem 1999 45: 2285-2287. [Full Text] [PDF]  

Patrick Schmit, Georges Gilson, and René L. Humbel

Evaluation of an Automated Enzyme Inhibition Assay for the Detection of Anti-Mitochondrial M2 Autoantibodies
Clin Chem 1999 45: 2287-2289. [Full Text] [PDF]  

Letters to the Editor:

John F. O’Connor, Galina Kovalevskaya, Steven Birken, and Ray K. Iles

Interference of Luteinizing Hormone ß-Core Fragment in Urinary Gonadotropin Assays • Dr. Iles responds:
Clin Chem 1999 45: 2290-2292. [Full Text] [PDF]  

Françoise Muller, Marguerite-Anne Bernard, Abdelkrim Benkirane, Sandrine Ngo, Stephen Lortat-Jacob, Jean-François Oury, and Marc Dommergues

Fetal Urine Cystatin C as a Predictor of Postnatal Renal Function in Bilateral Uropathies
Clin Chem 1999 45: 2292-2293. [Full Text] [PDF]  

David H. Wilson, Don M. Laird, Cathy M. Forsythe, Tom T. Biegalski, Anne L. Keller, and Robert J. Herrmann

Antibody Selection for the Abbott AxSYM Troponin I Assay
Clin Chem 1999 45: 2293-2294. [Full Text] [PDF]  

Gyorgy Csako

Mesna and Other Free-Sulfhydryl Compounds Produce False-Positive Results in a Urine Test Strip Method for Ascorbic Acid
Clin Chem 1999 45: 2295-2296. [Full Text] [PDF]  

Wim G. Meijer, Joost C.J.M. Swaanenburg, DirkJan van Veldhuisen, Ido P. Kema, Pax H.B. Willemse, and Elisabeth G.E. de Vries

Troponin I, Troponin T, and Creatine Kinase-MB Mass in Patients with the Carcinoid Syndrome with and without Heart Failure
Clin Chem 1999 45: 2296-2297. [Full Text] [PDF]  

Correction:

Correction
Clin Chem 1999 45: 2298-2299. [Full Text]  

Correction
Clin Chem 1999 45: 2299. [Full Text] [PDF]  

The Clinical Chemist:

Compiled by David E. Bruns, Editor (dbruns@aacc.org)
Clin Chem 1999 45: 2290-2299. [Full Text]  

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