Editorials:

Callum G. Fraser and Per Hyltoft Petersen

Analytical Performance Characteristics Should Be Judged against Objective Quality Specifications
Clin Chem 1999 45: 321-323. [Full Text] [PDF]  

Special Reports:

Jon F. Merz

Disease Gene Patents: Overcoming Unethical Constraints on Clinical Laboratory Medicine
Clin Chem 1999 45: 324-330. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Harald Esterbauer, Emanuel Hell, Franz Krempler, and Wolfgang Patsch

Allele-specific Differences in Apolipoprotein C-III mRNA Expression in Human Liver
Clin Chem 1999 45: 331-339. [Abstract] [Full Text] [PDF]  

Test Utilization and Outcomes:

Mary J. Emond, Mary P. Bronner, Timothy H. Carlson, Masami Lin, Robert F. Labbe, and Kris V. Kowdley

Quantitative Study of the Variability of Hepatic Iron Concentrations
Clin Chem 1999 45: 340-346. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

Margot H. Black, C. Linda Grass, Jari Leinonen, Ulf-Hakan Stenman, and Eleftherios P. Diamandis

Characterization of Monoclonal Antibodies for Prostate-specific Antigen and Development of Highly Sensitive Free Prostate-specific Antigen Assays
Clin Chem 1999 45: 347-354. [Abstract] [Full Text] [PDF]  

Theo P.J. Mulder, Daniel A. Court, and Wilbert H.M. Peters

Variability of Glutathione S-Transferase in Human Liver and Plasma
Clin Chem 1999 45: 355-359. [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Christa Cobbaert, Paul G.H. Mulder, Henk Baadenhuijsen, Louwerens Zwang, Cas W. Weykamp, and Pierre N.M. Demacker

Survey of Total Error of Precipitation and Homogeneous HDL-Cholesterol Methods and Simultaneous Evaluation of Lyophilized Saccharose-containing Candidate Reference Materials for HDL-Cholesterol
Clin Chem 1999 45: 360-370. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Werner Steimer

Performance and Specificity of Monoclonal Immunoassays for Cyclosporine Monitoring: How Specific Is Specific?
Clin Chem 1999 45: 371-381. [Abstract] [Full Text] [PDF]  

Gregory M. Sokol, Krisa P. Van Meurs, Linda L. Wright, Oswaldo Rivera, William. J. Thorn, III, Pamela M. Chu, and Robert L. Sams

Nitrogen Dioxide Formation during Inhaled Nitric Oxide Therapy
Clin Chem 1999 45: 382-387. [Abstract] [Full Text] [PDF]  

Tie Q. Wei, Victor P. Chu, Alan R. Craig, James E. Duffy, David M. Obzansky, Daniel Kilgore, Ignazio S. Masulli, Connie M. Sanders, and John C. Thompson

Automated Homogeneous Immunoassay for Gentamicin on the Dimension Clinical Chemistry System
Clin Chem 1999 45: 388-393. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

John Dutton, Andrew J. Hodgkinson, George Hutchinson, and Norman B. Roberts

Evaluation of a New Method for the Analysis of Free Catecholamines in Plasma Using Automated Sample Trace Enrichment with Dialysis and HPLC
Clin Chem 1999 45: 394-399. [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Diego Franciotta, Gianvito Martino, Elena Brambilla, Elisabetta Zardini, Vera Locatelli, Alessandra Bergami, Carmine Tinelli, Gaetano Desina, and Vittorio Cosi

TE671 Cell-based ELISA for Anti-Acetylcholine Receptor Antibody Determination in Myasthenia Gravis
Clin Chem 1999 45: 400-405. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Nora Bettinardi, Carla Colombo, and Carlo Corbetta

In Vitro Influence of Different Kinds of Fats on Results and Imprecision of Classic and Acid Steatocrits
Clin Chem 1999 45: 406-407. [Full Text] [PDF]  

Yukihiko Watanabe, Hisato Tada, Yoh Hidaka, Toru Takano, Keiko Takeoka, Shuji Fukata, Kanji Kuma, and Nobuyuki Amino

Polyethylene Glycol Increases the Detection of Anti-Thyrotropin Receptor Antibodies by a Radioreceptor Assay
Clin Chem 1999 45: 407-409. [Full Text] [PDF]  

Marcie J. Hursting, James L. Zehnder, James L. Joffrion, Jean-Claude Becker, Gary D. Knappenberger, and Richard P. Schwarz, Jr.

The International Normalized Ratio during Concurrent Warfarin and Argatroban Anticoagulation: Differential Contributions of Each Agent and Effects of the Choice of Thromboplastin Used
Clin Chem 1999 45: 409-412. [Full Text] [PDF]  

Elizabeth Caussé, Nathalie Siri, Hélène Bellet, Sandrine Champagne, Christophe Bayle, Pierre Valdiguié, Robert Salvayre, and Françoise Couderc

Plasma Homocysteine Determined by Capillary Electrophoresis with Laser-induced Fluorescence Detection
Clin Chem 1999 45: 412-414. [Full Text] [PDF]  

Marie P. Parsons, David J. Newman, Ronald G. Newall, and Christopher P. Price

Validation of a Point-of-Care Assay for the Urinary Albumin:Creatinine Ratio
Clin Chem 1999 45: 414-417. [Full Text] [PDF]  

Irina V. Kaplan and Stanley S. Levinson

Misleading Urinary Protein Pattern in a Patient with Hypogammaglobulinemia: Effects of Mechanical Concentration of Urine
Clin Chem 1999 45: 417-419. [Full Text] [PDF]  

Ekkehard Schütz, Maria Shipkova, Victor W. Armstrong, Eberhard Wieland, and Michael Oellerich

Identification of a Pharmacologically Active Metabolite of Mycophenolic Acid in Plasma of Transplant Recipients Treated with Mycophenolate Mofetil
Clin Chem 1999 45: 419-422. [Full Text] [PDF]  

Klaus Jung, Brigitte Brux, Angela Knäbich, Michael Lein, Pranav Sinha, Dietmar Schnorr, and Stefan A. Loening

A Gap Between Total Prostate-specific Antigen and the Sum of Free Prostate-specific Antigen Plus ₁-Antichymotrypsin-Prostate-specific Antigen in Patients with Prostate Carcinoma but not in Those with Benign Prostate Hyperplasia
Clin Chem 1999 45: 422-424. [Full Text] [PDF]  

David Baorto and Mitchell Scott

The Value of Screening Inpatients with Creatine Kinase Testing
Clin Chem 1999 45: 424-426. [Full Text] [PDF]  

Marion K. Stott, Andrew P. Fellowes, Jeff D. Upton, Michael J. Burt, and Peter M. George

Simple Multiplex PCR for the Simultaneous Detection of the C282Y and H63D Hemochromatosis (HFE) Gene Mutations
Clin Chem 1999 45: 426-428. [Full Text] [PDF]  

David H. Wilson, Janet Yu, Arden Karian, Janet Kozlowski, and Sara O'Reilly

Development and Multisite Evaluation of an Automated Assay for B₁₂ on the Abbott AxSYM Analyzer
Clin Chem 1999 45: 428-429. [Full Text] [PDF]  

Ina S. Klasen, Louis J.M. Reichert, Corrie M. de Kat Angelino, and Jack F.M. Wetzels

Quantitative Determination of Low and High Molecular Weight Proteins in Human Urine: Influence of Temperature and Storage Time
Clin Chem 1999 45: 430-432. [Full Text] [PDF]  

Pierre E. Wallemacq and Kathy Alexandre

Evaluation of the New AxSYM Cyclosporine Assay: Comparison with TDx Monoclonal Whole Blood and Emit Cyclosporine Assays
Clin Chem 1999 45: 432-435. [Full Text] [PDF]  

Letters to the Editor:

Michael N. Fahie-Wilson

Polyethylene Glycol Precipitation as a Screening Method for Macroprolactinemia
Clin Chem 1999 45: 436-437. [Full Text] [PDF]  

José Gilberto H. Vieira and Rui M.B. Maciel

Two of the authors of the Technical Brief cited above respond:
Clin Chem 1999 45: 437. [Full Text] [PDF]  

Charles van Heyningen, Ian D. Watson, and Amanda E. Morrice

Point-of-Care Testing Outcomes in an Emergency Department
Clin Chem 1999 45: 437-438. [Full Text] [PDF]  

Cas W. Weykamp, Kor Miedema, Tjeerd de Haan, and Cees J.A. Doelman

Carbamylated Hemoglobin Interference in Glycohemoglobin Assays
Clin Chem 1999 45: 438-440. [Full Text] [PDF]  

Tanguy Martin-Denavit, Guillaume Monneret, Jean Marc Labaune, Christian Isaac, Françoise Bienvenu, Guy Putet, and Jacques Bienvenu

Usefulness of Procalcitonin in Neonates at Risk for Infection
Clin Chem 1999 45: 440-441. [Full Text] [PDF]  

Christopher Sachse, Frank Dressler, and Eberhard Henkel

The authors of the report cited above respond:
Clin Chem 1999 45: 441. [Full Text] [PDF]  

Maurice M.A.L. Pelsers, Jean-Paul Chapelle, Marjo Knapen, Cees Vermeer, Arno M.M. Muijtjens, Wim T. Hermens, and Jan F.C. Glatz

Influence of Age and Sex and Day-to-Day and Within-Day Biological Variation on Plasma Concentrations of Fatty Acid-binding Protein and Myoglobin in Healthy Subjects
Clin Chem 1999 45: 441-443. [Full Text] [PDF]  

Enrico Cappellin, Rosalba Gatti, and Elio F. De Palo

Influence of Gender in Growth Hormone Status in Adults: Role of Urinary Growth Hormone
Clin Chem 1999 45: 443-444. [Full Text] [PDF]  

Correction:

Correction
Clin Chem 1999 45: 444. [Full Text] [PDF]  

The Clinical Chemist:

Compiled by David E. Bruns, Editor (dbruns@aacc.org)
Clin Chem 1999 45: 445-448. [Full Text] [PDF]  

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