Editorials:

Kenneth J. Friedman and Lawrence M. Silverman

Cystic Fibrosis Syndrome: A New Paradigm for Inherited Disorders and Implications for Molecular Diagnostics
Clin Chem 1999 45: 929-931. [Full Text] [PDF]  

Claus A. Pierach

Porphyria Conundrum
Clin Chem 1999 45: 932-933. [Full Text] [PDF]  

Special Reports:

Alan T. Remaley, Maureen L. Sampson, James M. DeLeo, Nancy A. Remaley, Beriuse D. Farsi, and Mark H. Zweig

Prevalence-Value-Accuracy Plots: A New Method for Comparing Diagnostic Tests Based on Misclassification Costs
Clin Chem 1999 45: 934-941. [Abstract] [Full Text] [PDF]  

Reviews:

Larry J. Kricka

Human Anti-Animal Antibody Interferences in Immunological Assays
Clin Chem 1999 45: 942-956. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Giuseppe Castaldo, Antonella Fuccio, Cécile Cazeneuve, Luigi Picci, Donatello Salvatore, Valeria Raia, Maurizio Scarpa, Michel Goossens, and Francesco Salvatore

Detection of Five Rare Cystic Fibrosis Mutations Peculiar to Southern Italy: Implications in Screening for the Disease and Phenotype Characterization for Patients with Homozygote Mutations
Clin Chem 1999 45: 957-962. [Abstract] [Full Text] [PDF]  

Ilona Larson, Michael M. Hoffmann, Jose M. Ordovas, Ernst J. Schaefer, Winfried März, and Jörg Kreuzer

The Lipoprotein Lipase HindIII Polymorphism: Association with Total Cholesterol and LDL-Cholesterol, but not with HDL and Triglycerides in 342 Females
Clin Chem 1999 45: 963-968. [Abstract] [Full Text] [PDF]  

Michelle Campbell, Joan S. Henthorn, and Sally C. Davies

Evaluation of Cation-Exchange HPLC Compared with Isoelectric Focusing for Neonatal Hemoglobinopathy Screening
Clin Chem 1999 45: 969-975. [Abstract] [Full Text] [PDF]  

Dan Tong, Margit Stimpfl, Alexander Reinthaller, Norbert Vavra, Silvia Müllauer-Ertl, Sepp Leodolter, and Robert Zeillinger

BRCA1 Gene Mutations in Sporadic Ovarian Carcinomas: Detection by PCR and Reverse Allele-specific Oligonucleotide Hybridization
Clin Chem 1999 45: 976-981. [Abstract] [Full Text] [PDF]  

Ingrid Laurendeau, Michel Bahuau, Nicolas Vodovar, Claire Larramendy, Martine Olivi, Ivan Bieche, Michel Vidaud, and Dominique Vidaud

TaqMan PCR-based Gene Dosage Assay for Predictive Testing in Individuals from a Cancer Family with INK4 Locus Haploinsufficiency
Clin Chem 1999 45: 982-986. [Abstract] [Full Text] [PDF]  

Test Utilization and Outcomes:

Arja Virtanen, Mehran Gomari, and Ries Kranse

Estimation of Prostate Cancer Probability by Logistic Regression: Free and Total Prostate-specific Antigen, Digital Rectal Examination, and Heredity Are Significant Variables
Clin Chem 1999 45: 987-994. [Abstract] [Full Text] [PDF]  

José A. Arranz, Encarnació Riudor, Margarita Rodés, Manuel Roig, Consuelo Climent, Vicente Rubio, Margarita Sentís, and Alberto Burlina

Optimization of Allopurinol Challenge: Sample Purification, Protein Intake Control, and the Use of Orotidine Response as a Discriminative Variable Improve Performance of the Test for Diagnosing Ornithine Carbamoyltransferase Deficiency
Clin Chem 1999 45: 995-1001. [Abstract] [Full Text]  

Enzymes and Protein Markers:

Margit Müller-Bardorff, Tilmann Rauscher, Markus Kampmann, Sven Schoolmann, Franz Laufenberg, Dieter Mangold, Rainer Zerback, Andrew Remppis, and Hugo A. Katus

Quantitative Bedside Assay for Cardiac Troponin T: A Complementary Method to Centralized Laboratory Testing
Clin Chem 1999 45: 1002-1008. [Abstract] [Full Text] [PDF]  

Barry C. Kress, Isaac A. Mizrahi, Karen W. Armour, Robert Marcus, Ronald D. Emkey, and Arthur C. Santora, II

Use of Bone Alkaline Phosphatase to Monitor Alendronate Therapy in Individual Postmenopausal Osteoporotic Women
Clin Chem 1999 45: 1009-1017. [Abstract] [Full Text] [PDF]  

Qinwei Shi, Mingfu Ling, Xiaochen Zhang, Minyuan Zhang, Lilly Kadijevic, Shigui Liu, and Joseph P. Laurino

Degradation of Cardiac Troponin I in Serum Complicates Comparisons of Cardiac Troponin I Assays
Clin Chem 1999 45: 1018-1025. [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Eva Fisher, Hubert Scharnagl, Michael M. Hoffmann, Klaus Kusterer, Daniela Wittmann, Heinrich Wieland, Werner Gross, and Winfried März

Mutations in the Apolipoprotein (apo) B-100 Receptor-binding region: Detection of apo B-100 (Arg³⁵⁰⁰Trp) Associated with Two New Haplotypes and Evidence That apo B-100 (Glu³⁴⁰⁵Gln) Diminishes Receptor-mediated Uptake of LDL
Clin Chem 1999 45: 1026-1038. [Abstract] [Full Text] [PDF]  

Leo J. Seman, Carl DeLuca, Jennifer L. Jenner, L. Adrienne Cupples, Judith R. McNamara, Peter W.F. Wilson, William P. Castelli, Jose M. Ordovas, and Ernst J. Schaefer

Lipoprotein(a)-Cholesterol and Coronary Heart Disease in the Framingham Heart Study
Clin Chem 1999 45: 1039-1046. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Magdalena Korecka, Dejan Nikolic, Richard B. van Breemen, and Leslie M. Shaw

The Apparent Inhibition of Inosine Monophosphate Dehydrogenase by Mycophenolic Acid Glucuronide Is Attributable to the Presence of Trace Quantities of Mycophenolic Acid
Clin Chem 1999 45: 1047-1050. [Abstract] [Full Text] [PDF]  

Alan H.B. Wu, Ben Bristol, Karen Sexton, Gina Cassella-McLane, Verena Holtman, and Dennis W. Hill

Adulteration of Urine by "Urine Luck"
Clin Chem 1999 45: 1051-1057. [Abstract] [Full Text] [PDF]  

John K. Fallon, Andrew T. Kicman, John A. Henry, Peter J. Milligan, David A. Cowan, and Andrew J. Hutt

Stereospecific Analysis and Enantiomeric Disposition of 3,4-Methylenedioxymethamphetamine (Ecstasy) in Humans
Clin Chem 1999 45: 1058-1069. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

J. Thomas Hindmarsh, Linda Oliveras, and Donald C. Greenway

Plasma Porphyrins in the Porphyrias
Clin Chem 1999 45: 1070-1076. [Abstract] [Full Text] [PDF] Correction  

Nutrition:

Graham Jennings, Leslie Bluck, Antony Wright, and Marinos Elia

The Use of Infrared Spectrophotometry for Measuring Body Water Spaces
Clin Chem 1999 45: 1077-1081. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Ole P. Børmer, Lise Marit Amlie, Elisabeth Paus, and Ulf Kongsgård

Automated Albumin Method Underestimates Pharmaceutical-Grade Albumin in Vivo
Clin Chem 1999 45: 1082-1084. [Full Text] [PDF]  

Anders Andersson, Arne Lindgren, Margret Arnadottir, Hanne Prytz, and Björn Hultberg

Thiols as a Measure of Plasma Redox Status in Healthy Subjects and in Patients with Renal or Liver Failure
Clin Chem 1999 45: 1084-1087. [Full Text] [PDF]  

David Zurakowski, James Di Canzio, and Joseph A. Majzoub

Pediatric Reference Intervals for Serum Thyroxine, Triiodothyronine, Thyrotropin, and Free Thyroxine
Clin Chem 1999 45: 1087-1091. [Full Text] [PDF]  

Andrew J. Hartland and Richard H. Neary

Serum Potassium Is Unreliable as an Estimate of in Vivo Plasma Potassium
Clin Chem 1999 45: 1091-1092. [Full Text] [PDF]  

Jennifer R. Galluzzi and Jose M. Ordovas

Genotyping Method for Point Mutation Detection in the Intestinal Fatty Acid Binding Protein, Using Fluorescent Probes
Clin Chem 1999 45: 1092-1094. [Full Text] [PDF]  

Charalampos Aslanidis and Gerd Schmitz

High-Speed Apolipoprotein E Genotyping and Apolipoprotein B3500 Mutation Detection Using Real-Time Fluorescence PCR and Melting Curves
Clin Chem 1999 45: 1094-1097. [Full Text] [PDF]  

Outi Ahokoski, Arja Virtanen, Veli Kairisto, Harry Scheinin, Risto Huupponen, and Kerttu Irjala

Biological Day-to-Day Variation and Reference Change Limits of Serum Cortisol and Aldosterone in Healthy Young Men on Unrestricted Diets
Clin Chem 1999 45: 1097-1099. [Full Text] [PDF]  

Letters to the Editor:

Poul Thirup

LUC, What Is That?
Clin Chem 1999 45: 1100. [Full Text] [PDF]  

Giuseppe Castaldo, Mariano Intrieri, Luigi Castellano, Ilario de Sio, Camillo Del Vecchio Blanco, Lucia Sacchetti, and Francesco Salvatore

Serum -Glutamyltransferase Isoform Complexed to LDL in the Diagnosis of Small Hepatocellular Carcinoma
Clin Chem 1999 45: 1100-1102. [Full Text]  

Ferdinando Mannello, Sara Barulli, Manuela Malatesta, Stefania Mancini, Pietro Leoni, and Giancarlo Gazzanelli

Prostate-specific Antigen Expression in Normal Human Bone Marrow Cells
Clin Chem 1999 45: 1102-1103. [Full Text] [PDF]  

National Academy of Clinical Biochemistry:

Alan H.B. Wu, Fred S. Apple, W. Brian Gibler, Robert L. Jesse, Myron M. Warshaw, and Roland Valdes, Jr.

National Academy of Clinical Biochemistry Standards of Laboratory Practice: Recommendations for the Use of Cardiac Markers in Coronary Artery Diseases
Clin Chem 1999 45: 1104-1121. [Abstract] [Full Text] [PDF]  

The Clinical Chemist:

Compiled by David E. Bruns, Editor (dbruns@aacc.org)
Clin Chem 1999 45: 1122-1128. [Full Text] [PDF]  

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