Editorials:

W. Davis Parker, Jr

The Other Genome
Clin Chem 1999 45: 1129-1130. [Full Text] [PDF]  

Laurence M. Demers

Biochemical Markers in the Management of Patients with Metastatic Bone Disease
Clin Chem 1999 45: 1131-1132. [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Alistair C. Jones, Jehannine Austin, Nancy Hansen, Bastiaan Hoogendoorn, Peter J. Oefner, Jeremy P. Cheadle, and Michael C. O'Donovan

Optimal Temperature Selection for Mutation Detection by Denaturing HPLC and Comparison to Single-Stranded Conformation Polymorphism and Heteroduplex Analysis
Clin Chem 1999 45: 1133-1140. [Abstract] [Full Text] [PDF]  

Markus Nauck, Heinrich Wieland, and Winfried März

Rapid, Homogeneous Genotyping of the 4G/5G Polymorphism in the Promoter Region of the PAI1 Gene by Fluorescence Resonance Energy Transfer and Probe Melting Curves
Clin Chem 1999 45: 1141-1147. [Abstract] [Full Text] [PDF]  

Ivan Bièche, Peter Onody, Ingrid Laurendeau, Martine Olivi, Dominique Vidaud, Rosette Lidereau, and Michel Vidaud

Real-Time Reverse Transcription-PCR Assay for Future Management of ERBB2-based Clinical Applications
Clin Chem 1999 45: 1148-1156. [Abstract] [Full Text] [PDF]  

Angela Harksen, Per Magne Ueland, Helga Refsum, and Klaus Meyer

Four Common Mutations of the Cystathionine ß-Synthase Gene Detected by Multiplex PCR and Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Clin Chem 1999 45: 1157-1161. [Abstract] [Full Text] [PDF]  

Tian-Jian Chen, Richard G. Boles, and Lee-Jun C. Wong

Detection of Mitochondrial DNA Mutations by Temporal Temperature Gradient Gel Electrophoresis
Clin Chem 1999 45: 1162-1167. [Abstract] [Full Text] [PDF]  

Test Utilization and Outcomes:

Beverly J. Smith and Michael D.D. McNeely

The Influence of an Expert System for Test Ordering and Interpretation on Laboratory Investigations
Clin Chem 1999 45: 1168-1175. [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

Mats RÅnby, Tony Gojceta, Kerstin Gustafsson, Kenny M. Hansson, and Tomas L. Lindahl

Isocitrate as Calcium Ion Activity Buffer in Coagulation Assays
Clin Chem 1999 45: 1176-1180. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

M. Pat Fox, Andrew A. Reilly, and Erasmus Schneider

Effect of the Ratio of Free to Total Prostate-specific Antigen on Interassay Variability in Proficiency Test Samples
Clin Chem 1999 45: 1181-1189. [Abstract] [Full Text] [PDF]  

Philippe H. Pfeifer, Marleen S. Kawahara, and Tony E. Hugli

Possible Mechanism for in Vitro Complement Activation in Blood and Plasma Samples: Futhan/EDTA Controls in Vitro Complement Activation
Clin Chem 1999 45: 1190-1199. [Abstract] [Full Text] [PDF]  

Gerdien W. de Valk-de Roo, Coen D.A. Stehouwer, Jan Lambert, Casper G. Schalkwijk, Marius J. van der Mooren, Cornelis Kluft, and Coen Netelenbos

Plasma Homocysteine Is Weakly Correlated with Plasma Endothelin and von Willebrand Factor but not with Endothelium-dependent Vasodilatation in Healthy Postmenopausal Women
Clin Chem 1999 45: 1200-1205. [Abstract] [Full Text] [PDF]  

Anders N. Pedersen, Nils Brünner, Gunilla Høyer-Hansen, Peter Hamer, David Jarosz, Birthe Larsen, Hans Jørgen Nielsen, and Ross W. Stephens

Determination of the Complex between Urokinase and Its Type-1 Inhibitor in Plasma from Healthy Donors and Breast Cancer Patients
Clin Chem 1999 45: 1206-1213. [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Philip J. Garry, Richard N. Baumgartner, Steven G. Brodie, George D. Montoya, Hwa Chi Liang, Robert D. Lindeman, and Thomas M. Williams

Estrogen Replacement Therapy, Serum Lipids, and Polymorphism of the Apolipoprotein E Gene
Clin Chem 1999 45: 1214-1223. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Robert L. Fitzgerald, Jeffrey D. Rivera, and David A. Herold

Broad Spectrum Drug Identification Directly from Urine, Using Liquid Chromatography-Tandem Mass Spectrometry
Clin Chem 1999 45: 1224-1234. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Britt Edén Engström, F. Anders Karlsson, and Leif Wide

Gender Differences in Diurnal Growth Hormone and Epinephrine Values in Young Adults during Ambulation
Clin Chem 1999 45: 1235-1239. [Abstract] [Full Text] [PDF]  

Alfredo Berruti, Luigi Dogliotti, Gabriella Gorzegno, Mirella Torta, Marco Tampellini, Marcello Tucci, Stefania Cerutti, Massimo Mosca Frezet, Michela Stivanello, Giovanna Sacchetto, and Alberto Angeli

Differential Patterns of Bone Turnover in Relation to Bone Pain and Disease Extent in Bone in Cancer Patients with Skeletal Metastases
Clin Chem 1999 45: 1240-1247. [Abstract] [Full Text] [PDF]  

Charles E. Petersen, Chung-Eun Ha, Krishna Harohalli, David S. Park, Jimmy B. Feix, Osamu Isozaki, and Nadhipuram V. Bhagavan

Structural Investigations of a New Familial Dysalbuminemic Hyperthyroxinemia Genotype
Clin Chem 1999 45: 1248-1254. [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Basil T. Doumas, Fred Yein, Billy Perry, Bernadine Jendrzejczak, and Arthur Kessner

Determination of the Sum of Bilirubin Sugar Conjugates in Plasma by Bilirubin Oxidase
Clin Chem 1999 45: 1255-1260. [Abstract] [Full Text] [PDF]  

Christine M. Pfeiffer, Dan L. Huff, S. Jay Smith, Dayton T. Miller, and Elaine W. Gunter

Comparison of Plasma Total Homocysteine Measurements in 14 Laboratories: An International Study
Clin Chem 1999 45: 1261-1268. [Abstract] [Full Text] [PDF]  

Other Areas of Clinical Chemistry:

Donald H. Chace, Barbara W. Adam, S. Jay Smith, J. Richard Alexander, Steven L. Hillman, and W. Harry Hannon

Validation of Accuracy-based Amino Acid Reference Materials in Dried-Blood Spots by Tandem Mass Spectrometry for Newborn Screening Assays
Clin Chem 1999 45: 1269-1277. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Françoise Muller, Philippe Aegerter, Sandrine Ngo, Agnès Fort, Alain Beauchet, Paul Giraudet, and Marc Dommergues

Software for Prenatal Down Syndrome Risk Calculation: A Comparative Study of Six Software Packages
Clin Chem 1999 45: 1278-1280. [Full Text] [PDF]  

Poul Thirup and Suzanne Ekelund

Day-to-Day, Postprandial, and Orthostatic Variation of Total Plasma Homocysteine
Clin Chem 1999 45: 1280-1283. [Full Text] [PDF]  

Robert A. Hegele, Christopher P. Busch, T. Kue Young, Philip W. Connelly, and Henian Cao

Mannose-binding Lectin Gene Variation and Cardiovascular Disease in Canadian Inuit
Clin Chem 1999 45: 1283-1285. [Full Text] [PDF]  

Pak Cheung R. Chan, Betty Y.L. Wong, Hilmi Ozcelik, and David E.C. Cole

Simple and Rapid Detection of BRCA1 and BRCA2 Mutations by Multiplex Mutagenically Separated PCR
Clin Chem 1999 45: 1285-1287. [Full Text] [PDF]  

Wolfgang T. Hofgärtner and Jonathan F. Tait

Characteristics of Clinical Molecular-Genetic Testing Laboratories in the United States
Clin Chem 1999 45: 1288-1290. [Full Text] [PDF]  

Sergi Lario, Pablo Iñigo, Josep M. Campistol, Esteban Poch, Francisca Rivera, and Federico Oppenheimer

Restriction Enzyme-based Method for Transforming Growth Factor-ß₁ Genotyping: Nonisotopic Detection of Polymorphisms in Codons 10 and 25 and the 5'-Flanking Region
Clin Chem 1999 45: 1290-1292. [Full Text] [PDF]  

Kwok-Wai Lo, Y.M. Dennis Lo, Sing-Fai Leung, Yuen-Shan Tsang, Lisa Y.S. Chan, Philip J. Johnson, N. Magnus Hjelm, Joseph C.K. Lee, and Dolly P. Huang

Analysis of Cell-free Epstein-Barr Virus-associated RNA in the Plasma of Patients with Nasopharyngeal Carcinoma
Clin Chem 1999 45: 1292-1294. [Full Text] [PDF]  

Takashi Miida, Fusako Yamazaki, Miho Sakurai, Reiko Wada, Toru Yamadera, Keiko Asami, Mari Hoshiyama, Akira Tanaka, Koichi Inano, and Masahiko Okada

The Apolipoprotein E Content of HDL in Cerebrospinal Fluid Is Higher in Children than in Adults
Clin Chem 1999 45: 1294-1296. [Full Text] [PDF]  

Alain Kumps, Pierre Duez, Janine Genin, and Yves Mardens

Gas Chromatography–Mass Spectrometry Analysis of Organic Acids: Altered Quantitative Response for Aqueous Calibrators and Dilute Urine Specimens
Clin Chem 1999 45: 1297-1300. [Full Text] [PDF]  

Shigui Liu, Min Yuan Zhang, Qianli Song, Xiaochen Zhang, Lilly Kadijevic, and Qinwei Shi

Extra Leader Sequence Affects Immunoactivity of Cardiac Troponin I
Clin Chem 1999 45: 1300-1302. [Full Text] [PDF] Correction  

Pauli Suominen, Kari Punnonen, Allan Rajamäki, Raimo Majuri, Veli Hänninen, and Kerttu Irjala

Automated Immunoturbidimetric Method for Measuring Serum Transferrin Receptor
Clin Chem 1999 45: 1302-1305. [Full Text] [PDF]  

Andreas Lun, Reinhard Ziebig, Friedrich Priem, Guido Filler, and Pranav Sinha

Routine Workflow for Use of Urine Strips and Urine Flow Cytometer UF-100 in the Hospital Laboratory,¹
Clin Chem 1999 45: 1305-1307. [Full Text] [PDF]  

Miyoko Takahashi, Andrea Chamczuk, Yuwen Hong, and George Jackowski

Rapid and Sensitive Immunoassay for the Measurement of Serum S100B Using Isoform-specific Monoclonal Antibody
Clin Chem 1999 45: 1307-1311. [Full Text] [PDF]  

Letters to the Editor:

Maryvonne Cuer, Sandrine Barrot, Françoise Jaureguy, Dieudonné Manéné, Geneviève Durand, and Gisèle Le Moël

The Plasma Homocysteine/Creatinine Ratio Can Be Used to Study the Implication of (C677T) MTHFR Genetic Variants in Homocysteine Homeostasis
Clin Chem 1999 45: 1312. [Full Text] [PDF]  

Cynthia R. Blessum, Neeta Khatter, and Stephen C. Alter

Technique to Remove Interference Caused by Radio-Opaque Agents in Clinical Capillary Zone Electrophoresis
Clin Chem 1999 45: 1313. [Full Text] [PDF]  

Marinus H. de Keijzer, Rob Brandts, and Belinda A.J. Giesendorf

Comment on the Overestimation of Methemoglobin Concentrations in Neonatal Samples with the Chiron 800 System CO-Oximeter Module
Clin Chem 1999 45: 1313-1314. [Full Text]  

Nicos Demetriou Christofides and Robert C. Hawkins

Furosemide Interference in Newer Free Thyroxine Assays • Dr. Hawkins responds:
Clin Chem 1999 45: 1315. [Full Text] [PDF]  

Jos T. Van Acker, Alain G. Verstraete, Marina A. Van Hamme, and Joris R. Delanghe

Falsely Increased Urinary Caffeine Attributable to Contamination by Urine Test Strips
Clin Chem 1999 45: 1315-1317. [Full Text]  

Frédéric Cotton, Béatrice Gulbis, Valérie Hansen, Françoise Vertongen, and Sumitra Dash

Interference of Hemoglobin D in Hemoglobin A₂ Measurement by Cation-Exchange HPLC • Dr. Dash responds:
Clin Chem 1999 45: 1317-1318. [Full Text] [PDF]  

Book Reviews:

Donald H. Chace

A Global View of LC/MS. How To Solve Your Most Challenging Analytical Problems. Ross Willoughby, Edward Sheehan, and Samuel Mitrovich. Pittsburgh, PA: Global View Publishing, 1998, 554 pp. Paperback. $49.95. ISBN 0-9660813-0-7.
Clin Chem 1999 45: 1319. [Full Text] [PDF]  

Proceedings of the 22nd Arnold O Beckman Conference:

Edward R. Ashwood

Raging Hormones: Closing the Loop from Bench to Bedside. The Twenty-Second Arnold O. Beckman Conference in Clinical Chemistry
Clin Chem 1999 45: 1321-1322. [Abstract] [Full Text] [PDF]  

George G. Klee

Maximizing Efficacy of Endocrine Tests: Importance of Decision-focused Testing Strategies and Appropriate Patient Preparation
Clin Chem 1999 45: 1323-1330. [Abstract] [Full Text] [PDF]  

Åke Lernmark

Type 1 Diabetes
Clin Chem 1999 45: 1331-1338. [Abstract] [Full Text] [PDF]  

Harold E. Lebovitz

Type 2 Diabetes: An Overview
Clin Chem 1999 45: 1339-1345. [Abstract] [Full Text] [PDF]  

Gregory R. Mundy and Theresa A. Guise

Hormonal Control of Calcium Homeostasis
Clin Chem 1999 45: 1347-1352. [Abstract] [Full Text] [PDF]  

Lawrence G. Raisz

Physiology and Pathophysiology of Bone Remodeling
Clin Chem 1999 45: 1353-1358. [Abstract] [Full Text] [PDF] Correction  

Nelson B. Watts

Clinical Utility of Biochemical Markers of Bone Remodeling
Clin Chem 1999 45: 1359-1368. [Abstract] [Full Text] [PDF]  

Horace M. Perry, III

The Endocrinology of Aging
Clin Chem 1999 45: 1369-1376. [Abstract] [Full Text] [PDF]  

Michael M. Kaplan

Clinical Perspectives in the Diagnosis of Thyroid Disease
Clin Chem 1999 45: 1377-1383. [Abstract] [Full Text] [PDF]  

Clifford J. Rosen

Serum Insulin-like Growth Factors and Insulin-like Growth Factor-binding Proteins: Clinical Implications
Clin Chem 1999 45: 1384-1390. [Abstract] [Full Text] [PDF]  

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