Minireview:

Michael Mayer

Association of Serum Bilirubin Concentration with Risk of Coronary Artery Disease
Clin Chem 2000 46: 1723-1727. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Ekkehard Schütz, Nicolas von Ahsen, and Michael Oellerich

Genotyping of Eight Thiopurine Methyltransferase Mutations: Three-Color Multiplexing, "Two-Color/Shared" Anchor, and Fluorescence-quenching Hybridization Probe Assays Based on Thermodynamic Nearest-Neighbor Probe Design
Clin Chem 2000 46: 1728-1737. [Abstract] [Full Text] [PDF]  

Jochen Wilhelm, Meinhard Hahn, and Alfred Pingoud

Influence of DNA Target Melting Behavior on Real-Time PCR Quantification
Clin Chem 2000 46: 1738-1743. [Abstract] [Full Text] [PDF]  

Evidence-based Laboratory Medicine and Test Utilization:

Bjørn J. Bolann, Jan Dag Solli, Jörn Schneede, Kjell A. Grøttum, Arne Loraas, Morgan Stokkeland, Asbjørn Stallemo, Arne Schjøth, Rolf Bruun Bie, Helga Refsum, and Per Magne Ueland

Evaluation of Indicators of Cobalamin Deficiency Defined as Cobalamin-induced Reduction in Increased Serum Methylmalonic Acid
Clin Chem 2000 46: 1744-1750. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

Sari L. Alatalo, Jussi M. Halleen, Teuvo A. Hentunen, Jukka Mönkkönen, and H. Kalervo Väänänen

Rapid Screening Method for Osteoclast Differentiation in Vitro That Measures Tartrate-resistant Acid Phosphatase 5b Activity Secreted into the Culture Medium
Clin Chem 2000 46: 1751-1754. [Abstract] [Full Text] [PDF]  

Harri Härmä, Piia Tarkkinen, Tero Soukka, and Timo Lövgren

Miniature Single-Particle Immunoassay for Prostate-specific Antigen in Serum Using Recombinant Fab Fragments
Clin Chem 2000 46: 1755-1761. [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Gary L. Myers, Mary M. Kimberly, Parvin P. Waymack, S. Jay Smith, Gerald R. Cooper, and Eric J. Sampson

A Reference Method Laboratory Network for Cholesterol: A Model for Standardization and Improvement of Clinical Laboratory Measurements
Clin Chem 2000 46: 1762-1772. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Rita Paroni, Barbara Comuzzi, Cinzia Arcelloni, Stefano Brocco, Saula de Kreutzenberg, Antonio Tiengo, Alessandra Ciucci, Paolo Beck-Peccoz, and Stefano Genovese

Comparison of Capillary Electrophoresis with HPLC for Diagnosis of Factitious Hypoglycemia
Clin Chem 2000 46: 1773-1780. [Abstract] [Full Text] [PDF]  

Jun Yoshinaga, Amit Chatterjee, Yasuyuki Shibata, Masatoshi Morita, and John S. Edmonds

Human Urine Certified Reference Material for Arsenic Speciation
Clin Chem 2000 46: 1781-1786. [Abstract] [Full Text] [PDF]  

Karl B. Scheidweiler, Jalil Shojaie, Mark A. Plessinger, Ronald W. Wood, and Tai C. Kwong

Stability of Methylecgonidine and Ecgonidine in Sheep Plasma in Vitro
Clin Chem 2000 46: 1787-1795. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Eli S. Jacoby, Andrew T. Kicman, Paul Laidler, and Ray K. Iles

Determination of the Glycoforms of Human Chorionic Gonadotropin ß-Core Fragment by Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Clin Chem 2000 46: 1796-1803. [Abstract] [Full Text] [PDF]  

Mark J. Magera, Janice K. Helgeson, Dietrich Matern, and Piero Rinaldo

Methylmalonic Acid Measured in Plasma and Urine by Stable-Isotope Dilution and Electrospray Tandem Mass Spectrometry
Clin Chem 2000 46: 1804-1810. [Abstract] [Full Text] [PDF]  

Laboratory Management:

Wytze P. Oosterhuis, Herman J.L.M. Ulenkate, and Henk M.J. Goldschmidt

Evaluation of LabRespond, a New Automated Validation System for Clinical Laboratory Test Results
Clin Chem 2000 46: 1811-1817. [Abstract] [Full Text] [PDF]  

Nutrition:

Mridula Chopra, Maura E. O’Neill, Nora Keogh, Gary Wortley, Susan Southon, and David I. Thurnham

Influence of Increased Fruit and Vegetable Intake on Plasma and Lipoprotein Carotenoids and LDL Oxidation in Smokers and Nonsmokers
Clin Chem 2000 46: 1818-1829. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Ana Maria Wägner, José Luis Sánchez-Quesada, Antonio Pérez, Mercedes Rigla, Mariano Cortés, Francisco Blanco-Vaca, and Jordi Ordóñez-Llanos

Inaccuracy of Calculated LDL-Cholesterol in Type 2 Diabetes: Consequences for Patient Risk Classification and Therapeutic Decisions
Clin Chem 2000 46: 1830-1832. [Extract] [Full Text] [PDF]  

Leo L.M. Poon, Tse N. Leung, Tze K. Lau, and Y.M. Dennis Lo

Presence of Fetal RNA in Maternal Plasma
Clin Chem 2000 46: 1832-1834. [Extract] [Full Text] [PDF]  

Ron H.N. van Schaik, Saskia N. de Wildt, Nienke M. van Iperen, Andre G. Uitterlinden, John N. van den Anker, and Jan Lindemans

CYP3A4-V Polymorphism Detection by PCR-Restriction Fragment Length Polymorphism Analysis and Its Allelic Frequency among 199 Dutch Caucasians
Clin Chem 2000 46: 1834-1836. [Extract] [Full Text] [PDF]  

Andreas Lun, Markus Schmitt, and Harald Renz

Phagocytosis and Oxidative Burst: Reference Values for Flow Cytometric Assays Independent of Age
Clin Chem 2000 46: 1836-1839. [Extract] [Full Text] [PDF]  

Luis Borque, Laura Bellod, Antonio Rus, M. Luisa Seco, and Francisco Galisteo-González

Development and Validation of an Automated and Ultrasensitive Immunoturbidimetric Assay for C-Reactive Protein
Clin Chem 2000 46: 1839-1842. [Extract] [Full Text] [PDF]  

Doroti Pirulli, Michele Boniotto, Daniela Puzzer, Andrea Spanò, Antonio Amoroso, and Sergio Crovella

Flexibility of Melting Temperature Assay for Rapid Detection of Insertions, Deletions, and Single-Point Mutations of the AGXT Gene Responsible for Type 1 Primary Hyperoxaluria
Clin Chem 2000 46: 1842-1844. [Extract] [Full Text] [PDF]  

Juha Horsti

Measurement of Prothrombin Time in EDTA Plasma with Combined Thromboplastin Reagent,
Clin Chem 2000 46: 1844-1846. [Extract] [Full Text] [PDF]  

Gisela Skopp, Lucia Pötsch, and Martin Mauden

Stability of Cannabinoids in Hair Samples Exposed to Sunlight
Clin Chem 2000 46: 1846-1848. [Extract] [Full Text] [PDF]  

Brian D. Ragland, Robert J. Konrad, Carolyn Chaffin, C. Andrew Robinson, and Robert W. Hardy

Evaluation of a Homogeneous Direct LDL-Cholesterol Assay in Diabetic Patients: Effect of Glycemic Control
Clin Chem 2000 46: 1848-1851. [Extract] [Full Text] [PDF]  

Nicholas J. Panaro, Po Ki Yuen, Taku Sakazume, Paolo Fortina, Larry J. Kricka, and Peter Wilding

Evaluation of DNA Fragment Sizing and Quantification by the Agilent 2100 Bioanalyzer
Clin Chem 2000 46: 1851-1853. [Extract] [Full Text] [PDF]  

Christiane Wylenzek, Martina Engelmann, Dirk Holten, Reuel Van Atta, Michael Wood, and Birgit Gathof

Evaluation of a Nucleic Acid-based Cross-Linking Assay to Screen for Hereditary Hemochromatosis in Healthy Blood Donors
Clin Chem 2000 46: 1853-1855. [Extract] [Full Text] [PDF]  

Eleftherios P. Diamandis, George M. Yousef, Judith Clements, Linda K. Ashworth, Shigetaka Yoshida, Torbjorn Egelrud, Peter S. Nelson, Sadao Shiosaka, Sheila Little, Hans Lilja, Ulf-Hakan Stenman, Harry G. Rittenhouse, and Hester Wain

New Nomenclature for the Human Tissue Kallikrein Gene Family
Clin Chem 2000 46: 1855-1858. [Extract] [Full Text] [PDF]  

Hiromichi Suzuki, Sohji Nagase, Shuichi Kikuchi, Ying Wang, and Akio Koyama

Association of a Missense Glu298Asp Mutation of the Endothelial Nitric Oxide Synthase Gene with End Stage Renal Disease
Clin Chem 2000 46: 1858-1860. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Knud J. Helsing, Sandra C. Hoffman, and George W. Comstock

Temperature Variations in Chest-type Mechanical Freezers
Clin Chem 2000 46: 1861. [Extract] [Full Text] [PDF]  

Christian M. Hackeng, Leonne A.M. de Bruijn, Connie M. Douw, and Marja P. van Dieijen-Visser

Presence of Birefringent, Maltese-Cross-appearing Spherules in Synovial Fluid in a Case of Acute Monoarthritis
Clin Chem 2000 46: 1861-1863. [Extract] [Full Text] [PDF]  

Nantaya Chanarat, Prasit Chanarat, and Damrong Chiewsilp

Soluble Fas in Serum of Patients with HIV/AIDS
Clin Chem 2000 46: 1863-1864. [Extract] [Full Text] [PDF]  

Jean-Paul Chapelle, Marie-Claire Aldenhoff, Luc Pierard, and Jacques Gielen

Comparison of Cardiac Troponin I Measurements on Whole Blood and Plasma on the Stratus CS Analyzer and Comparison with AxSYM
Clin Chem 2000 46: 1864-1866. [Extract] [Full Text] [PDF]  

Michael Heesen, Dagmar Kunz, Rolf Rossaint, and Brunhilde Blömeke

Real-Time PCR Assay with Fluorescent Hybridization Probes for Rapid Genotyping of the CD14 Promotor Polymorphism
Clin Chem 2000 46: 1866-1867. [Extract] [Full Text] [PDF]  

John McLaren Howard, Dinesh Talwar, and Denis St. JO’Reilly

Assessment of Vitamin B₁ Status
Clin Chem 2000 46: 1867-1868. [Extract] [Full Text] [PDF]  

Darina Behúlová, Vladimír Bzdúch, Darina Holesová, Alena Vasilenková, and Jozef Ponec

Transient Hyperphosphatasemia of Infancy and Childhood: Study of 194 Cases
Clin Chem 2000 46: 1868-1869. [Extract] [Full Text] [PDF]  

Pascale Beyne, Jean-Pierre Vigier, Pierre Bourgoin, and Michel Vidaud

Comparison of Single and Repeat Centrifugation of Blood Specimens Collected in BD Evacuated Blood Collection Tubes Containing a Clot Activator for Cardiac Troponin I Assay on the ACCESS Analyzer
Clin Chem 2000 46: 1869-1870. [Extract] [Full Text] [PDF]  

Paul C. Adams and Vipin Bhayana

Unsaturated Iron-binding Capacity: A Screening Test for C282Y Hemochromatosis?
Clin Chem 2000 46: 1870-1871. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Jeanette Roberts

Toxicology and Clinical Pharmacology of Herbal Products. Melanie Johns Cupp, ed. Totowa, NJ: Humana Press, 2000, 325 pp., $89.50. ISBN 0-89603-791-6.
Clin Chem 2000 46: 1872. [Extract] [Full Text] [PDF]  

Brian S. Erler

Pathology for the Health-Related Professions, 2nd ed. Ivan Damjanov. Philadelphia, PA: WB Saunders, 2000, 545 pp., $52.00. ISBN 0-7216-8118-2.
Clin Chem 2000 46: 1872-1873. [Extract] [Full Text] [PDF]  

Correction:

Correction for vol. 46, p. 18
Clin Chem 2000 46: 1873. [Extract] [Full Text] [PDF]  

2000 San Diego Conference:

The Current Revolution: SNPs and Chips in Molecular Diagnostics November 16–18, 2000
Clin Chem 2000 46: 1874-1881. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Compiled by David E. Bruns, Editor (dbruns@aacc.org)
Clin Chem 2000 46: 1882. [Extract] [Full Text] [PDF]  

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