Editorials:

Larry J. Kricka

Interferences in Immunoassay—Still a Threat
Clin Chem 2000 46: 1037-1038. [Extract] [Full Text] [PDF]  

Y.M. Dennis Lo

Molecular Testing of Urine: Catching DNA on the Way Out
Clin Chem 2000 46: 1039-1040. [Extract] [Full Text] [PDF]  

Reviews:

Christopher P. Price

Evidence-based Laboratory Medicine: Supporting Decision-Making
Clin Chem 2000 46: 1041-1050. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Martin J. Hessner, Mary Ann Budish, and Kenneth D. Friedman

Genotyping of Factor V G1691A (Leiden) without the Use of PCR by Invasive Cleavage of Oligonucleotide Probes
Clin Chem 2000 46: 1051-1056. [Abstract] [Full Text] [PDF]  

Niels Wedemeyer, Wolfgang Göhde, and Thomas Pötter

Flow Cytometric Analysis of Reverse Transcription-PCR Products: Quantification of p21^WAF1/CIP1 and Proliferating Cell Nuclear Antigen mRNA
Clin Chem 2000 46: 1057-1064. [Abstract] [Full Text] [PDF]  

Steinar Hustad, Per Magne Ueland, Stein Emil Vollset, Ying Zhang, Anne Lise Bjørke-Monsen, and Jørn Schneede

Riboflavin as a Determinant of Plasma Total Homocysteine: Effect Modification by the Methylenetetrahydrofolate Reductase C677T Polymorphism
Clin Chem 2000 46: 1065-1071. [Abstract] [Full Text] [PDF]  

Martin Hersberger, Jacqueline Marti-Jaun, Katharina Rentsch, and Edgar Hänseler

Rapid Detection of the CYP2D6*3, CYP2D6*4, and CYP2D6*6 Alleles by Tetra-Primer PCR and of the CYP2D6*5 Allele by Multiplex Long PCR
Clin Chem 2000 46: 1072-1077. [Abstract] [Full Text] [PDF]  

Irina Botezatu, Ol’ga Serdyuk, Galina Potapova, Valery Shelepov, Raisa Alechina, Yuriy Molyaka, Vitaliy Anan’ev, Igor Bazin, August Garin, Mehti Narimanov, Vasiliy Knysh, Hovsep Melkonyan, Samuil Umansky, and Anatoly Lichtenstein

Genetic Analysis of DNA Excreted in Urine: A New Approach for Detecting Specific Genomic DNA Sequences from Cells Dying in an Organism
Clin Chem 2000 46: 1078-1084. [Abstract] [Full Text] [PDF]  

Evidence-based Laboratory Medicine and Test Utilization:

Marita du Plessis, Johan B. Ubbink, and W.J. Hayward Vermaak

Analytical Quality of Near-Patient Blood Cholesterol and Glucose Determinations
Clin Chem 2000 46: 1085-1090. [Abstract] [Full Text] [PDF]  

Yuzuru Takemura, Haku Ishida, Yuji Inoue, Hiroyuki Kobayashi, and J. Robert Beck

Opportunistic Discovery of Occult Disease by Use of Test Panels in New, Symptomatic Primary Care Outpatients: Yield and Cost of Case Finding
Clin Chem 2000 46: 1091-1098. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

Michael Christiansen, Irakli Jaliashvili, Michael T. Overgaard, Christian Ensinger, Peter Obrist, and Claus Oxvig

Quantification and Characterization of Pregnancy-associated Complexes of Angiotensinogen and the Proform of Eosinophil Major Basic Protein in Serum and Amniotic Fluid
Clin Chem 2000 46: 1099-1105. [Abstract] [Full Text] [PDF]  

György Sölétormos and Vibeke Schiøler

Description of a Computer Program to Assess Cancer Antigen 15.3, Carcinoembryonic Antigen, and Tissue Polypeptide Antigen Information during Monitoring of Metastatic Breast Cancer
Clin Chem 2000 46: 1106-1113. [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Axel Stachon, Andreas Böning, Heike Weisser, Axel Laczkovics, Guido Skipka, and Michael Krieg

Prognostic Significance of Low Serum Cholesterol after Cardiothoracic Surgery
Clin Chem 2000 46: 1114-1120. [Abstract] [Full Text] [PDF]  

Margarita Esteban-Salán, Amada Guimón-Bardesi, Jesús María de la Viuda-Unzueta, María Nerea Azcarate-Ania, Pilar Pascual-Usandizaga, and Eduardo Amoroto-Del-Río

Analytical and Clinical Evaluation of Two Homogeneous Assays for LDL-Cholesterol in Hyperlipidemic Patients
Clin Chem 2000 46: 1121-1131. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Martha Burt, David C. Anderson, Julie Kloss, and Fred S. Apple

Evidence-based Implementation of Free Phenytoin Therapeutic Drug Monitoring
Clin Chem 2000 46: 1132-1135. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Anne Caillot-Augusseau, Laurence Vico, Martina Heer, Dimitri Voroviev, Jean-Claude Souberbielle, Armin Zitterman, Christian Alexandre, and Marie-Hélène Lafage-Proust

Space Flight Is Associated with Rapid Decreases of Undercarboxylated Osteocalcin and Increases of Markers of Bone Resorption without Changes in Their Circadian Variation: Observations in Two Cosmonauts
Clin Chem 2000 46: 1136-1143. [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Michael Landt

Glyceraldehyde Preserves Glucose Concentrations in Whole Blood Specimens
Clin Chem 2000 46: 1144-1149. [Abstract] [Full Text] [PDF]  

Ebba Nexo, Frode Engbaek, Per Magne Ueland, Christina Westby, Paudy O’Gorman, Carole Johnston, Bengt Frode Kase, Anne B. Guttormsen, Ingrid Alfheim, Joseph McPartlin, David Smith, Jan Møller, Karsten Rasmussen, Robert Clarke, John M. Scott, and Helga Refsum

Evaluation of Novel Assays in Clinical Chemistry: Quantification of Plasma Total Homocysteine
Clin Chem 2000 46: 1150-1156. [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Michael Covinsky, Omar Laterza, John D. Pfeifer, Tunde Farkas-Szallasi, and Mitchell G. Scott

An IgM Antibody to Escherichia coli Produces False-Positive Results in Multiple Immunometric Assays
Clin Chem 2000 46: 1157-1161. [Abstract] [Full Text] [PDF]  

Nutrition:

Mridula Chopra, Patricia E.E. Fitzsimons, John J. Strain, David I. Thurnham, and Alan N. Howard

Nonalcoholic Red Wine Extract and Quercetin Inhibit LDL Oxidation without Affecting Plasma Antioxidant Vitamin and Carotenoid Concentrations
Clin Chem 2000 46: 1162-1170. [Abstract] [Full Text] [PDF]  

Case Conference:

Theresa M. Ambrose, Muhammad Al-Lozi, and Mitchell G. Scott

Bone Lead Concentrations Assessed by in Vivo X-Ray Fluorescence
Clin Chem 2000 46: 1171-1178. [Abstract] [Full Text] [PDF]  

Technical Briefs:

David W. Holt, Terry Lee, Kirsty Jones, and Atholl Johnston

Validation of an Assay for Routine Monitoring of Sirolimus Using HPLC with Mass Spectrometric Detection
Clin Chem 2000 46: 1179-1183. [Extract] [Full Text] [PDF]  

Tester F. Ashavaid, Altaf A. Kondkar, and Kappiareth G. Nair

Identification of Two LDL-Receptor Mutations Causing Familial Hypercholesterolemia in Indian Subjects by a Simplified Rapid PCR-Heteroduplex Method
Clin Chem 2000 46: 1183-1185. [Extract] [Full Text] [PDF]  

Guido Crisponi, Rossano Ambu, Franco Cristiani, Gabriella Mancosu, Valeria Marina Nurchi, Rosalba Pinna, and Gavino Faa

Does Iron Concentration in a Liver Needle Biopsy Accurately Reflect Hepatic Iron Burden in ß-Thalassemia?
Clin Chem 2000 46: 1185-1188. [Extract] [Full Text] [PDF]  

Frederic Gómez, Jordi Camps, Josep M. Simó, Natàlia Ferré, and Jorge Joven

Agreement Study of Methods Based on the Elimination Principle for the Measurement of LDL- and HDL-Cholesterol Compared with Ultracentrifugation in Patients with Liver Cirrhosis
Clin Chem 2000 46: 1188-1191. [Extract] [Full Text] [PDF]  

Frank A.J.T.M. van den Bergh, Arletta M. van Oeveren-Dybicz, and Michelle A.M. Bon

Rapid Single-Tube Genotyping of the Factor V Leiden and Prothrombin Mutations by Real-Time PCR Using Dual-Color Detection
Clin Chem 2000 46: 1191-1195. [Extract] [Full Text] [PDF]  

Adalbert Kowalski, Daniela Radu, and Bert Gold

Colorimetric Microwell Plate Detection of the Factor V Leiden Mutation
Clin Chem 2000 46: 1195-1198. [Extract] [Full Text] [PDF] Additional Tables  

Zahur Zaman and Stefaan De Raedt

Ischemic Exercise Testing in Suspected McArdle Disease
Clin Chem 2000 46: 1198-1199. [Extract] [Full Text] [PDF]  

László Góth, András Gorzsás, and Tibor Kalmár

A Simple PCR-Heteroduplex Screening Method for Detection of a Common Mutation of the Catalase Gene in Hungary
Clin Chem 2000 46: 1199-1200. [Extract] [Full Text] [PDF]  

Angelo Lomeo and Andrea Bolner

Stability of Several Biochemical Markers of Bone Metabolism
Clin Chem 2000 46: 1200-1202. [Extract] [Full Text] [PDF]  

Daisuke Furuya, Atsuhito Yagihashi, Syunichi Nasu, Teruo Endoh, Tohru Nakamura, Reiko Kaneko, Chinatsu Kamagata, Daisuke Kobayashi, and Naoki Watanabe

LDL Particle Size by Gradient-Gel Electrophoresis Cannot Be Estimated by LDL-Cholesterol/Apolipoprotein B Ratios
Clin Chem 2000 46: 1202-1203. [Extract] [Full Text] [PDF]  

Leif Dibbelt

Does Trisialo-Transferrin Provide Valuable Information for the Laboratory Diagnosis of Chronically Increased Alcohol Consumption by Determination of Carbohydrate-deficient Transferrin?
Clin Chem 2000 46: 1203-1205. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Thierry Le Bricon, Eric Thervet, Marc Froissart, Mourad Benlakehal, Bernard Bousquet, Christophe Legendre, and Danielle Erlich

Plasma Cystatin C Is Superior to 24-h Creatinine Clearance and Plasma Creatinine for Estimation of Glomerular Filtration Rate 3 Months after Kidney Transplantation
Clin Chem 2000 46: 1206-1207. [Extract] [Full Text] [PDF]  

Anthony W. Butch

Falsely Increased Values for Rabbit Immunoglobulin-based Nephelometric Immunoassays Attributable to Human Anti-Rabbit Antibodies
Clin Chem 2000 46: 1207-1208. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Compiled by David E. Bruns, Editor (dbruns@aacc.org)
Clin Chem 2000 46: 1209-1212. [Extract] [Full Text] [PDF]  

Proceedings of the 23rd Arnold O Beckman Conference:

Edward R. Ashwood

Advances in Clinical Laboratory Hematology. The Twenty-Third Arnold O. Beckman Conference in Clinical Chemistry
Clin Chem 2000 46: 1213-1214. [Extract] [Full Text] [PDF]  

Patrick C.J. Ward

The CBC at the Turn of the Millennium: An Overview
Clin Chem 2000 46: 1215-1220. [Abstract] [Full Text] [PDF]  

Michael Brown and Carl Wittwer

Flow Cytometry: Principles and Clinical Applications in Hematology
Clin Chem 2000 46: 1221-1229. [Abstract] [Full Text] [PDF]  

Mohammed Attaelmannan and Stanley S. Levinson

Understanding and Identifying Monoclonal Gammopathies
Clin Chem 2000 46: 1230-1238. [Abstract] [Full Text] [PDF]  

Roy D. Baynes, Caroline Hamm, Roger Dansey, Jared Klein, Lucinda Cassells, Chatchada Karanes, Esteban Abella, and William P. Peters

Bone Marrow and Peripheral Blood Hematopoietic Stem Cell Transplantation: Focus on Autografting
Clin Chem 2000 46: 1239-1251. [Abstract] [Full Text] [PDF]  

Robert W. McKenna

Multifaceted Approach to the Diagnosis and Classification of Acute Leukemias
Clin Chem 2000 46: 1252-1259. [Abstract] [Full Text] [PDF]  

Douglas A. Triplett

Coagulation and Bleeding Disorders: Review and Update
Clin Chem 2000 46: 1260-1269. [Abstract] [Full Text] [PDF]  

Paul M. Ness

Transfusion Medicine: An Overview and Update
Clin Chem 2000 46: 1270-1276. [Abstract] [Full Text] [PDF]  

George G. Klee

Cobalamin and Folate Evaluation: Measurement of Methylmalonic Acid and Homocysteine vs Vitamin B₁₂ and Folate
Clin Chem 2000 46: 1277-1283. [Abstract] [Full Text] [PDF]  

Gwendolyn M. Clarke and Trefor N. Higgins

Laboratory Investigation of Hemoglobinopathies and Thalassemias: Review and Update
Clin Chem 2000 46: 1284-1290. [Abstract] [Full Text] [PDF]  

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