Editorials:

Daniel W. Chan and Lori J. Sokoll

WHO First International Standards for Prostate-specific Antigen: The Beginning of the End for Assay Discrepancies?
Clin Chem 2000 46: 1291-1292. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Jonas Bergquist, Oluf Andersen, and Ann Westman

Rapid Method to Characterize Mutations in Transthyretin in Cerebrospinal Fluid from Familial Amyloidotic Polyneuropathy Patients by Use of Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Clin Chem 2000 46: 1293-1300. [Abstract] [Full Text] [PDF]  

Y.M. Dennis Lo, Tze K. Lau, Lisa Y.S. Chan, Tse N. Leung, and Allan M.Z. Chang

Quantitative Analysis of the Bidirectional Fetomaternal Transfer of Nucleated Cells and Plasma DNA
Clin Chem 2000 46: 1301-1309. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

Brian Rafferty, Peter Rigsby, Matthew Rose, Thomas Stamey, and Rose Gaines Das

Reference Reagents for Prostate-specific Antigen (PSA): Establishment of the First International Standards for Free PSA and PSA (90:10)
Clin Chem 2000 46: 1310-1317. [Abstract] [Full Text] [PDF]  

Kandiah Umapathysivam, Alison M. Whittle, Enzo Ranieri, Colleen Bindloss, Elaine M. Ravenscroft, Otto P. van Diggelen, John J. Hopwood, and Peter J. Meikle

Determination of Acid -Glucosidase Protein: Evaluation as a Screening Marker for Pompe Disease and Other Lysosomal Storage Disorders
Clin Chem 2000 46: 1318-1325. [Abstract] [Full Text] [PDF]  

Mitsuhiro Ohta, Kiyoe Ohta, Jie Ma, Juji Takeuchi, Takahiko Saida, Masataka Nishimura, and Nobuyuki Itoh

Clinical and Analytical Evaluation of an Enzyme Immunoassay for Myelin Basic Protein in Cerebrospinal Fluid
Clin Chem 2000 46: 1326-1330. [Abstract] [Full Text] [PDF]  

Jeffrey J. Chance, Edward J. Norris, and Martin H. Kroll

Mechanism of Interference of a Polymerized Hemoglobin Blood Substitute in an Alkaline Phosphatase Method
Clin Chem 2000 46: 1331-1337. [Abstract] [Full Text] [PDF]  

Hugo Stiegler, Yuriko Fischer, Jaime F. Vazquez-Jimenez, Jürgen Graf, Karsten Filzmaier, Bernd Fausten, Uwe Janssens, Axel M. Gressner, and Dagmar Kunz

Lower Cardiac Troponin T and I Results in Heparin-Plasma Than in Serum
Clin Chem 2000 46: 1338-1344. [Abstract] [Full Text] [PDF]  

Diana Wayand, Hannsjörg Baum, Gabriele Schätzle, Julia Schärf, and Dieter Neumeier

Cardiac Troponin T and I in End-Stage Renal Failure
Clin Chem 2000 46: 1345-1350. [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Hua Fei, Satoshi Maeda, Hirokazu Kirii, Suwako Fujigaki, Naoya Maekawa, Hidehiko Fujii, Hisayasu Wada, Kuniaki Saito, and Mitsuru Seishima

Evaluation of Two Different Homogeneous Assays for LDL-Cholesterol in Lipoprotein-X-positive Serum
Clin Chem 2000 46: 1351-1356. [Abstract] [Full Text] [PDF]  

Tomoichiro Oka, Takeshi Kujiraoka, Mayumi Ito, Makoto Nagano, Mitsuaki Ishihara, Tadao Iwasaki, Tohru Egashira, Norman E. Miller, and Hiroaki Hattori

Measurement of Human Plasma Phospholipid Transfer Protein by Sandwich ELISA
Clin Chem 2000 46: 1357-1364. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Rosa Bergés, Jordi Segura, Rosa Ventura, Kenneth D. Fitch, Alan R. Morton, Magí Farré, Marta Mas, and Xavier de la Torre

Discrimination of Prohibited Oral Use of Salbutamol from Authorized Inhaled Asthma Treatment
Clin Chem 2000 46: 1365-1375. [Abstract] [Full Text] [PDF]  

Olga Millan, Federic Oppenheimer, Merce Brunet, Jordi Vilardell, Isabel Rojo, Jordi Vives, and Jaume Martorell

Assessment of Mycophenolic Acid-induced Immunosuppression: A New Approach
Clin Chem 2000 46: 1376-1383. [Abstract] [Full Text] [PDF]  

Hematology:

Paul Froom, Barbara Bieganiec, Zahava Ehrenrich, and Mira Barak

Stability of Common Analytes in Urine Refrigerated for 24 h before Automated Analysis by Test Strips
Clin Chem 2000 46: 1384-1386. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Jochen Reinsberg, Jörg Dembinski, Christoph Dorn, Daniela Behrendt, Peter Bartmann, and Hans van der Ven

Determination of Total Interleukin-8 in Whole Blood after Cell Lysis
Clin Chem 2000 46: 1387-1394. [Abstract] [Full Text] [PDF]  

Laboratory Management:

Marita Kailajärvi, Timo Takala, Paula Grönroos, Nils Tryding, Jorma Viikari, Kerttu Irjala, and Jari Forsström

Reminders of Drug Effects on Laboratory Test Results
Clin Chem 2000 46: 1395-1400. [Abstract] [Full Text] [PDF]  

Nutrition:

Moncef Feki, Malek Souissi, Elyes Mokhtar, Mohamed Hsairi, Naziha Kaabachi, Helena Antebi, Louis Gérald Alcindor, Rachid Mechmeche, and Abderraouf Mebazaa

Vitamin E and Coronary Heart Disease in Tunisians
Clin Chem 2000 46: 1401-1405. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Pietro Palatini, Maura Floreani, Roberto Padrini, Pierpaolo Piccoli, Massimo Bertoli, Lorenzo Calò, and Rocco Orlando

Effects of Chronic Renal Failure and Hemodialysis on the Monoethylglycinexylidide Liver Function Test,
Clin Chem 2000 46: 1406-1408. [Extract] [Full Text] [PDF]  

Jos H.H. Thijssen, Stephanie H.M. Van Goozen, Herman Van Engeland, Luz M.P. Matute, and Marinus A. Blankenstein

None of Four Commercially Available Assays Detects Prolactin in Human Saliva
Clin Chem 2000 46: 1409-1410. [Extract] [Full Text] [PDF]  

Mercè Garcia-Barceló, Lok Yee Chow, Kwok Lim Lam, Helen Fung Kum Chiu, Yun Kowk Wing, and Mary Miu Yee Waye

Occurrence of CYP2D6 Gene Duplication in Hong Kong Chinese
Clin Chem 2000 46: 1411-1413. [Extract] [Full Text] [PDF]  

Ursula Gutteck-Amsler and Katharina M. Rentsch

Quantification of the Aminosteroidal Non-Depolarizing Neuromuscular Blocking Agents Rocuronium and Vecuronium in Plasma with Liquid Chromatography-Tandem Mass Spectroscopy
Clin Chem 2000 46: 1413-1414. [Extract] [Full Text] [PDF]  

Charlotte Bukowski, Mary Ann Grigg, and Christopher Longcope

Sex Hormone-binding Globulin Concentration: Differences Among Commercially Available Methods
Clin Chem 2000 46: 1415-1416. [Extract] [Full Text] [PDF]  

Bruno Costes, Emmanuelle Girodon, Dominique Vidaud, Elisabeth Flori, Azarnouche Ardalan, Patricia Conteville, Pascale Fanen, Florence Niel, Michel Vidaud, and Michel Goossens

Prenatal Detection by Real-Time Quantitative PCR and Characterization of a New CFTR Deletion, 3600+15kbdel5.3kb (or CFTRdele19)
Clin Chem 2000 46: 1417-1420. [Extract] [Full Text] [PDF]  

Ivy H.N. Wong, Y.M. Dennis Lo, Paul B.S. Lai, and Philip J. Johnson

Relationship of p16 Methylation Status and Serum -Fetoprotein Concentration in Hepatocellular Carcinoma Patients
Clin Chem 2000 46: 1420-1422. [Extract] [Full Text] [PDF]  

Ronald Bellisario, Robert J. Colinas, and Kenneth A. Pass

Simultaneous Measurement of Thyroxine and Thyrotropin from Newborn Dried Blood-Spot Specimens Using a Multiplexed Fluorescent Microsphere Immunoassay
Clin Chem 2000 46: 1422-1424. [Extract] [Full Text] [PDF]  

History:

Leonard T. Skeggs, Jr

Persistence ... and Prayer: From the Artificial Kidney to the AutoAnalyzer
Clin Chem 2000 46: 1425-1436. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Xavier Fuentes-Arderiu

Uncertainty of Measurement in Clinical Laboratory Sciences
Clin Chem 2000 46: 1437-1438. [Extract] [Full Text] [PDF]  

Simone Neemeshkanna, Olfert Landt, Hans F. Merk, and Brunhilde Blömeke

Fluorogenic Probes to Detect the A_-444C Transversion in the Leukotriene C4 Synthase Promoter
Clin Chem 2000 46: 1438-1439. [Extract] [Full Text] [PDF]  

Franca Pagani and Mauro Panteghini

Biological Variation in Serum Type I Collagen Carboxy-Terminal Telopeptide Concentrations
Clin Chem 2000 46: 1439-1440. [Extract] [Full Text] [PDF]  

Pascal Pernet, Elisabeth Lasnier, and Michel Vaubourdolle

Evaluation of the AxSYM Homocysteine Assay and Comparison with the IMx Homocysteine Assay
Clin Chem 2000 46: 1440-1441. [Extract] [Full Text] [PDF]  

Gregory Tetrault

Failure of Processed Quality-Control Materials to Detect Interference from Labile Form of Hemoglobin A_1c
Clin Chem 2000 46: 1442. [Extract] [Full Text] [PDF]  

Pamela S. Ulmer and A. Wayne Meikle

Sample Requirements for Plasma Renin Activity and Immunoreactive Renin
Clin Chem 2000 46: 1442-1444. [Extract] [Full Text] [PDF]  

Adrian C. Sewell, Martin Heil, Anika Blieke, Armin Mosandl, and Hans Böhles

Rapid Enantiomeric Differentiation of Urinary Metabolites in a Patient with Bacterial Overgrowth Syndrome
Clin Chem 2000 46: 1444-1445. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Amadeo J. Pesce and Myer G. Horowitz

Four Centuries of Clinical Chemistry. Louis Rosenfeld. Amsterdam, The Netherlands: Gordon and Breach Science Publishers, 1999, 592 pp., $149.00. ISBN 90-5699-645-2.
Clin Chem 2000 46: 1446. [Extract] [Full Text] [PDF]  

John Fenton

GC/MS in Clinical Chemistry. P. Gerhards, U. Bonns, J. Sawazki, J. Szigan, and A. Wertmann. Weinheim, Germany: Wiley-VCH, 1999, 241 pp. ISBN 3-527-29623-9.
Clin Chem 2000 46: 1446-1447. [Extract] [Full Text] [PDF]  

Paul L. Wolf

Biographies and Other Essays on the History of Clinical Chemistry. Louis Rosenfeld, editor. Washington, DC: AACC Press, History Division, 1999, 381 pp., $12.00. ISBN 1-890883-21-2.
Clin Chem 2000 46: 1447-1448. [Extract] [Full Text] [PDF]  

Oak Ridge Conference:

Andreas Scorilas, Anders Bjartell, Hans Lilja, Christina Moller, and Eleftherios P. Diamandis

Streptavidin-Polyvinylamine Conjugates Labeled with a Europium Chelate: Applications in Immunoassay, Immunohistochemistry, and Microarrays
Clin Chem 2000 46: 1450-1455. [Abstract] [Full Text] [PDF]  

Weiping Qian, Danfeng Yao, Fang Yu, Bin Xu, Rong Zhou, Xiang Bao, and Zuhong Lu

Immobilization of Antibodies on Ultraflat Polystyrene Surfaces
Clin Chem 2000 46: 1456-1463. [Abstract] [Full Text] [PDF]  

Alla Lishanski

Screening for Single-Nucleotide Polymorphisms Using Branch Migration Inhibition in PCR-amplified DNA
Clin Chem 2000 46: 1464-1470. [Abstract] [Full Text] [PDF]  

Rajesh Patel, Reinhold Pollner, Steve de Keczer, John Pease, Marcel Pirio, Neal DeChene, Alan Dafforn, and Sam Rose

Quantification of DNA Using the Luminescent Oxygen Channeling Assay
Clin Chem 2000 46: 1471-1477. [Abstract] [Full Text] [PDF]  

Allan S. Hoffman

Bioconjugates of Intelligent Polymers and Recognition Proteins for Use in Diagnostics and Affinity Separations
Clin Chem 2000 46: 1478-1486. [Abstract] [Full Text] [PDF]  

Abstracts of Oak Ridge Posters:

Rajesh Patel, Rinie van Beuningen, Dianne van Strijp, and Nurith Kurn

Quantification of HIV-1 RNA Using a Homogeneous Single-Tube Assay
Clin Chem 2000 46: 1487-1488. [Extract] [Full Text] [PDF]  

Fang Yu, Danfeng Yao, and Weiping Qian

Reflectometry Interference Spectroscopy in Detection of Hepatitis B Surface Antigen
Clin Chem 2000 46: 1489-1490. [Extract] [Full Text] [PDF]  

Wolfgang Hoesel, Jochen Peter, Helmut Lenz, and Carlo Unverzagt

Purification of Prostate-specific Antigen from Serum by Indirect Immunosorption and Elution with a Hapten
Clin Chem 2000 46: 1490-1491. [Extract] [Full Text] [PDF]  

Koichi Morimoto and Kuniyo Inouye

Application of Bispecific F(ab')_2µ Fragments Prepared from IgMs against Carcinoembryonic Antigen and Alkaline Phosphatase
Clin Chem 2000 46: 1492-1493. [Extract] [Full Text] [PDF]  

R. Anthony Shaw, Sarah Low-Ying, Michael Leroux, and Henry H. Mantsch

Toward Reagent-free Clinical Analysis: Quantitation of Urine Urea, Creatinine, and Total Protein from the Mid-Infrared Spectra of Dried Urine Films
Clin Chem 2000 46: 1493-1495. [Extract] [Full Text] [PDF]  

Alan Dafforn, Hrair Kirakossian, and Kaiqin Lao

Miniaturization of the Luminescent Oxygen Channeling Immunoassay (LOCI^TM) for Use in Multiplex Array Formats and Other Biochips
Clin Chem 2000 46: 1495-1497. [Extract] [Full Text] [PDF]  

Sherry A. Dunbar and James W. Jacobson

Application of the Luminex LabMAP in Rapid Screening for Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator Gene: A Pilot Study
Clin Chem 2000 46: 1498-1500. [Extract] [Full Text] [PDF]  

Hiroshi Uehara, Glenn Nardone, Sandra Randall, Yuri Khripin, and Dan St. Louis

Rapid and Sensitive Closed-Tube Quantification of Human Interferon- mRNA by Reverse Transcription-PCR Utilizing Energy-Transfer Labeled Primers
Clin Chem 2000 46: 1500-1501. [Extract] [Full Text] [PDF]  

Robert Jenison, Ayla Haeberli, Shao Yang, Barry Polisky, and Rachel Ostroff

Thin Film Biosensor for Rapid Detection of mecA from Methicillin-resistant Staphylococcus aureus
Clin Chem 2000 46: 1501-1504. [Extract] [Full Text] [PDF]  

Alexander D. Romaschin and Paul M. Walker

Endotoxin Activity in Whole Blood by Neutrophil Chemiluminescence—A Novel Analytical Paradigm
Clin Chem 2000 46: 1504-1506. [Extract] [Full Text] [PDF]  

Yen Ping Liu, Steve de Keczer, Svetlana Alexander, Marcel Pirio, Dariush Davalian, Nurith Kurn, and Edwin F. Ullman

Homogeneous, Rapid Luminescent Oxygen Channeling Immunoassay (LOCI^TM) for Homocysteine
Clin Chem 2000 46: 1506-1507. [Extract] [Full Text] [PDF]  

Susan K.W. Nanda and Wendy K. Scholz

A Distinctive Surface for Phospholipid Assays
Clin Chem 2000 46: 1508-1510. [Extract] [Full Text] [PDF]  

Farzad Pourahmadi, Mike Taylor, Greg Kovacs, Kristen Lloyd, Stan Sakai, Tamlyn Schafer, Bret Helton, Linda Western, Sandy Zaner, Jesus Ching, Bill McMillan, Phil Belgrader, and M. Allen Northrup

Toward a Rapid, Integrated, and Fully Automated DNA Diagnostic Assay for Chlamydia trachomatis and Neisseria gonorrhoeae
Clin Chem 2000 46: 1511-1513. [Extract] [Full Text] [PDF]  

Darryl Erik Palmer-Toy, David A. Sarracino, Dennis Sgroi, Rebbecca LeVangie, and Peter E. Leopold

Direct Acquisition of Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectra from Laser Capture Microdissected Tissues
Clin Chem 2000 46: 1513-1516. [Extract] [Full Text] [PDF]  

Pierre Morissette, Martin Beaulieu, and Bernard Vinet

A Specific Artificial Antibody toward Mycophenolic Acid Prepared by Molecular Imprinting
Clin Chem 2000 46: 1516-1518. [Extract] [Full Text] [PDF]  

Ernest V. Groman and Christopher P. Reinhardt

Hepatocyte Asialoglycoprotein Receptor Assay Using Stable Isotopes and Neutron Activation Analysis
Clin Chem 2000 46: 1519-1521. [Extract] [Full Text] [PDF]  

Judy Ash, George Baxevanakis, Lela Bilandzic, Howard Shin, and Lilly Kadijevic

Development of an Automated Quantitative Latex Immunoassay for Cardiac Troponin I in Serum,
Clin Chem 2000 46: 1521-1522. [Extract] [Full Text] [PDF]  

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