Editorials:

Sinuhe Hahn, Xiao Yan Zhong, and Wolfgang Holzgreve

Quantification of Circulating DNA: In the Preparation Lies the Rub
Clin Chem 2001 47: 1577-1578. [Extract] [Full Text] [PDF]  

Reviews:

G. Russell Warnick, Matthias Nauck, and Nader Rifai

Evolution of Methods for Measurement of HDL-Cholesterol: From Ultracentrifugation to Homogeneous Assays
Clin Chem 2001 47: 1579-1596. [Abstract] [Full Text] [PDF]  

Armando Tripodi and Pier Mannuccio Mannucci

Laboratory Investigation of Thrombophilia
Clin Chem 2001 47: 1597-1606. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Rossa W. K. Chiu, Leo L. M. Poon, Tze K. Lau, Tse N. Leung, Eric M. C. Wong, and Y. M. Dennis Lo

Effects of Blood-Processing Protocols on Fetal and Total DNA Quantification in Maternal Plasma
Clin Chem 2001 47: 1607-1613. [Abstract] [Full Text] [PDF]  

Igor L. Medintz, Lorenzo Berti, Charles A. Emrich, Jennifer Tom, James R. Scherer, and Richard A. Mathies

Genotyping Energy-Transfer-Cassette-labeled Short-Tandem-Repeat Amplicons with Capillary Array Electrophoresis Microchannel Plates
Clin Chem 2001 47: 1614-1621. [Abstract] [Full Text] [PDF]  

Osamu Samura, Satoshi Sohda, Kirby L. Johnson, Barbara Pertl, Steven Ralston, Laurent C. Delli-Bovi, and Diana W. Bianchi

Diagnosis of Trisomy 21 in Fetal Nucleated Erythrocytes from Maternal Blood by Use of Short Tandem Repeat Sequences
Clin Chem 2001 47: 1622-1626. [Abstract] [Full Text] [PDF]  

Roddey E. Ford, Mark J. Magera, Karen M. Kloke, Paul A. Chezick, Abdul Fauq, and Joseph P. McConnell

Quantitative Measurement of Porphobilinogen in Urine by Stable-Isotope Dilution Liquid Chromatography-Tandem Mass Spectrometry
Clin Chem 2001 47: 1627-1632. [Abstract] [Full Text] [PDF]  

Gerald Le Gac, Catherine Mura, and Claude Férec

Complete Scanning of the Hereditary Hemochromatosis Gene (HFE) by Use of Denaturing HPLC
Clin Chem 2001 47: 1633-1640. [Abstract] [Full Text] [PDF]  

Kumiko Ohkubo, Akemi Yamano, Mariko Nagashima, Yumiko Mori, Keizo Anzai, Yuko Akehi, Riku Nomiyama, Takashi Asano, Akinori Urae, and Junko Ono

Mitochondrial Gene Mutations in the tRNA^Leu(UUR) Region and Diabetes: Prevalence and Clinical Phenotypes in Japan
Clin Chem 2001 47: 1641-1648. [Abstract] [Full Text] [PDF]  

Evidence-based Laboratory Medicine and Test Utilization:

Nobuhide Hayashi, Tomoko Kawamoto, Masahiko Mukai, Akio Morinobu, Masahiro Koshiba, Shinichi Kondo, Soichiro Maekawa, and Shunichi Kumagai

Detection of Antinuclear Antibodies by Use of an Enzyme Immunoassay with Nuclear HEp-2 Cell Extract and Recombinant Antigens: Comparison with Immunofluorescence Assay in 307 Patients
Clin Chem 2001 47: 1649-1659. [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

Isabelle Gouin-Thibault, Bruno Cassinat, Christine Chomienne, Jean-Didier Rain, Yves Najean, and Marie-Hélène Schlageter

Is the Thrombopoietin Assay Useful for Differential Diagnosis of Thrombocytopenia? Analysis of a Cohort of 160 Patients with Thrombocytopenia and Defined Platelet Life Span
Clin Chem 2001 47: 1660-1665. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

Kerstin Scheld, Armin Zittermann, Martina Heer, Birgit Herzog, Claudia Mika, Christian Drummer, and Peter Stehle

Nitrogen Metabolism and Bone Metabolism Markers in Healthy Adults during 16 Weeks of Bed Rest
Clin Chem 2001 47: 1688-1695. [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Mehran Haidari, Ebrahim Javadi, Arashmidos Sanati, Mehrdad Hajilooi, and Jafar Ghanbili

Association of Increased Ferritin with Premature Coronary Stenosis in Men
Clin Chem 2001 47: 1666-1672. [Abstract] [Full Text] [PDF]  

Josep M. Simó, Jordi Camps, Elisabet Vilella, Federico Gómez, Antonio Paul, and Jorge Joven

Instability of Lipoprotein(a) in Plasma Stored at -70 °C : Effects of Concentration, Apolipoprotein(a) Genotype, and Donor Cardiovascular Disease
Clin Chem 2001 47: 1673-1678. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Raffaele Caruso, Norberto Perico, Dario Cattaneo, Giampiero Piccinini, Samantha Bonazzola, Giuseppe Remuzzi, and Flavio Gaspari

Whole-Blood Calcineurin Activity Is Not Predicted by Cyclosporine Blood Concentration in Renal Transplant Recipients
Clin Chem 2001 47: 1679-1687. [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Giuliana Fortunato, Giuseppe Castaldo, Giovannangelo Oriani, Raimondo Cerini, Mariano Intrieri, Eugenia Molinaro, Ivan Gentile, Guglielmo Borgia, Marcello Piazza, Francesco Salvatore, and Lucia Sacchetti

Multivariate Discriminant Function Based on Six Biochemical Markers in Blood Can Predict the Cirrhotic Evolution of Chronic Hepatitis
Clin Chem 2001 47: 1696-1700. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Johan E. de Vries, Petal A.H.M. Wijnen, Karly Hamulyák, Marja P. van Dieijen-Visser, and Otto Bekers

PCR on Cell Lysates Obtained from Whole Blood Circumvents DNA Isolation
Clin Chem 2001 47: 1701-1702. [Extract] [Full Text] [PDF]  

Desmond I. Bannon and J. Julian Chisolm, Jr

Anodic Stripping Voltammetry Compared with Graphite Furnace Atomic Absorption Spectrophotometry for Blood Lead Analysis
Clin Chem 2001 47: 1703-1704. [Extract] [Full Text] [PDF]  

Darryl E. Palmer-Toy, Zbigniew M. Szczepiorkowski, Vivian Shih, and Elizabeth M. Van Cott

Compatibility of the Abbott IMx Homocysteine Assay with Citrate-Anticoagulated Plasma and Stability of Homocysteine in Citrated Whole Blood
Clin Chem 2001 47: 1704-1707. [Extract] [Full Text] [PDF]  

Robert A. Hegele, Matthew R. Ban, and T. Kue Young

Serum C-Reactive Protein in Canadian Inuit and Its Association with Genetic Variation on Chromosome 1q21
Clin Chem 2001 47: 1707-1709. [Extract] [Full Text] [PDF]  

Ellen B. Duly, George Barnes, Sandra Grimason, and Thomas R. Trinick

Analytical Performance of Specific-Protein Assays on the Abbott Aeroset System
Clin Chem 2001 47: 1709-1710. [Extract] [Full Text] [PDF]  

Rivka Mamet, Mario Sztern, Avinoam Rachmel, Bracha Stahl, Daniel Flusser, and Nili Schoenfeld

Lead Poisoning: A New Biochemical Perspective on the Differentiation Between Acquired and Hereditary Neuroporphyria
Clin Chem 2001 47: 1710-1713. [Extract] [Full Text] [PDF]  

Youssef Hijazi, Magali Bolon, and Roselyne Boulieu

Stability of Ketamine and Its Metabolites Norketamine and Dehydronorketamine in Human Biological Samples
Clin Chem 2001 47: 1713-1715. [Extract] [Full Text] [PDF]  

Sigi Rotmensch, Claudio Celentano, Nelli Elliger, Oscar Sadan, Dan Lehman, Abraham Golan, and Marek Glezerman

Diurnal Variation of Human Chorionic Gonadotropin ß-Core Fragment Concentrations in Urine during Second Trimester of Pregnancy
Clin Chem 2001 47: 1715-1717. [Extract] [Full Text] [PDF]  

Kerryn A. Greive, Nicholas D.H. Balazs, and Wayne D. Comper

Protein Fragments in Urine Have Been Considerably Underestimated by Various Protein Assays
Clin Chem 2001 47: 1717-1719. [Extract] [Full Text] [PDF]  

Pierre M. Llorca, François Coudore, Christophe Corpelet, Aurelie Buyens, Monique Hoareau, and Alain Eschalier

Integration of Olanzapine Determinations in a HPLC-Diode Array Detection System for Routine Psychotropic Drug Monitoring
Clin Chem 2001 47: 1719-1721. [Extract] [Full Text] [PDF]  

Ole D. Wolthers, Carsten Heuck, and Lene Heickendorff

Diurnal Variations in Serum and Urine Markers of Type I and Type III Collagen Turnover in Children
Clin Chem 2001 47: 1721-1722. [Extract] [Full Text] [PDF]  

Silvia Martini, Giulio Mengozzi, Giuseppe Aimo, Roberto Pagni, and Carla Sategna-Guidetti

Diagnostic Accuracies for Celiac Disease of Four Tissue Transglutaminase Autoantibody Tests Using Human Antigen
Clin Chem 2001 47: 1722-1725. [Extract] [Full Text] [PDF]  

Jens Lykkesfeldt

Determination of Malondialdehyde as Dithiobarbituric Acid Adduct in Biological Samples by HPLC with Fluorescence Detection: Comparison with Ultraviolet-Visible Spectrophotometry
Clin Chem 2001 47: 1725-1727. [Extract] [Full Text] [PDF]  

Ferenc Somogyvári, Zoltán Szolnoki, János Márki-Zay, and Lajos Fodor

Real-Time PCR Assay with Fluorescent Hybridization Probes for Exact and Rapid Genotyping of the Angiotensin-converting Enzyme Gene Insertion/Deletion Polymorphism
Clin Chem 2001 47: 1728-1729. [Extract] [Full Text] [PDF]  

Atsuhito Yagihashi, Koichi Asanuma, Masashi Nakamura, Jan Araya, Yoshinori Mano, Torigoe Torigoe, Daisuke Kobayashi, and Naoki Watanabe

Detection of Anti-Survivin Antibody in Gastrointestinal Cancer Patients
Clin Chem 2001 47: 1729-1731. [Extract] [Full Text] [PDF]  

Juha Horsti

EDTA Samples Are Stable for Prothrombin Time Measurement by Combined Thromboplastin Reagent
Clin Chem 2001 47: 1731-1732. [Extract] [Full Text] [PDF]  

Marie-Louise L. Boumans, Jart H.C. Diris, Marius Nap, Arno M.M. Muijtjens, Jos G. Maessen, Marja P. van Dieijen-Visser, and Wim T. Hermens

Creatine Kinase Isoenzyme MB (CKMB) Controversy: Perimortal Tissue Acidosis May Explain the Absence of CKMB in Myocardium at Autopsy
Clin Chem 2001 47: 1733-1735. [Extract] [Full Text] [PDF]  

Eduardo Chaler, Alicia Belgorosky, Mercedes Maceiras, Mariano Mendioroz, and Marco A. Rivarola

Between-Assay Differences in Serum Growth Hormone (GH) Measurements: Importance in the Diagnosis of GH Deficiency in Childhood
Clin Chem 2001 47: 1735-1738. [Extract] [Full Text] [PDF]  

Bjørn G. Nedrebø, Ottar Nygård, Per M. Ueland, and Ernst A. Lien

Plasma Total Homocysteine in Hyper- and Hypothyroid Patients before and during 12 Months of Treatment
Clin Chem 2001 47: 1738-1741. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Kentaro Nagamine, Keiko Watanabe, Kimihiko Ohtsuka, Tetsu Hase, and Tsugunori Notomi

Loop-mediated Isothermal Amplification Reaction Using a Nondenatured Template
Clin Chem 2001 47: 1742-1743. [Extract] [Full Text] [PDF]  

David S. Fran and Michael W. Sundberg

RE: Europium Nanoparticles and Time-resolved Fluorescence for Ultrasensitive Detection of Prostate-specific Antigen
Clin Chem 2001 47: 1743-1744. [Extract] [Full Text] [PDF]  

Rebecca S. Ayash

High-Sensitivity C-Reactive Protein: Product Claims and the Food and Drug Administration
Clin Chem 2001 47: 1743. [Extract] [Full Text] [PDF]  

Marva M. Moxey-Mims

Comment on "High-Sensitivity C-Reactive Protein: Product Claims and the Food and Drug Administration"
Clin Chem 2001 47: 1743. [Extract] [Full Text] [PDF]  

Kenneth L. Sisco

Is RNA in Serum Bound to Nucleoprotein Complexes?
Clin Chem 2001 47: 1744-1745. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

J. Robert Beck

Safe and Sound: Artificial Intelligence in Hazardous Applications. John Fox and Subrata Das. Menlo Park, CA: AAAI Press/MIT Press, 2000, 325 pp., $40.00. ISBN 0-262-06211-9.
Clin Chem 2001 47: 1746. [Extract] [Full Text] [PDF]  

Paul Murphy

Robbins Review of Pathology. Edward Klatt and Vinay Kumar, eds. Philadelphia: WB Saunders, 2000, 311 pp., $32.00. ISBN 0-7216-8259-6.
Clin Chem 2001 47: 1746-1747. [Extract] [Full Text] [PDF]  

Erik Magid

Evidence-Based Medicine. How to Practice and Teach EBM, 2nd ed. David L. Sackett, Sharon E. Straus, W. Scott Richardson, William Rosenberg, and R. Brian Haynes. Edinburgh: Churchill Livingstone, 2000, 261 pp. (plus one compact disc), $34.95. ISBN 0-443-06240-4.
Clin Chem 2001 47: 1747. [Extract] [Full Text] [PDF]  

Addenda:

Clin Chem 2001 47: 1748. [Extract] [Full Text] [PDF]  

Corrections:

Clin Chem 2001 47: 1748. [Extract] [Full Text] [PDF]  

Clin Chem 2001 47: 1748. [Extract] [Full Text] [PDF]  

Correction:

Correction for vol. 47, p. 1089
Clin Chem 2001 47: 1748. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Clin Chem 2001 47: 1749-1750. [Extract] [Full Text] [PDF]  

Accent^®:

ACCENT® Continuing Education Credit for Readers of Clinical Chemistry
Clin Chem 2001 47: 1751-1752. [Extract] [Full Text] [PDF]  

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