Editorials:

Lucian L. Leape

Striving for Perfection
Clin Chem 2002 48: 1871-1872. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Elaine M. Weidenhammer, Brenda F. Kahl, Ling Wang, Larry Wang, Melanie Duhon, Jo Ann Jackson, Matthew Slater, and Xiao Xu

Multiplexed, Targeted Gene Expression Profiling and Genetic Analysis on Electronic Microarrays
Clin Chem 2002 48: 1873-1882. [Abstract] [Full Text] [PDF] Data Supplement  

Lynne Rainen, Uwe Oelmueller, Stewart Jurgensen, Ralf Wyrich, Cynthia Ballas, Jim Schram, Chris Herdman, Danute Bankaitis-Davis, Nancy Nicholls, David Trollinger, and Victor Tryon

Stabilization of mRNA Expression in Whole Blood Samples
Clin Chem 2002 48: 1883-1890. [Abstract] [Full Text] [PDF]  

Raili Kauppinen and Mikael von und zu Fraunberg

Molecular and Biochemical Studies of Acute Intermittent Porphyria in 196 Patients and Their Families
Clin Chem 2002 48: 1891-1900. [Abstract] [Full Text] [PDF]  

Lee-Jun C. Wong, Min-Hui Liang, Haeyoung Kwon, John Park, Ren-Kui Bai, and Duan-Jun Tan

Comprehensive Scanning of the Entire Mitochondrial Genome for Mutations
Clin Chem 2002 48: 1901-1912. [Abstract] [Full Text] [PDF]  

Olaf A. Bodamer, Dan Bercovich, Michael Schlabach, Christie Ballantyne, Danièle Zoch, and Arthur L. Beaudet

Use of Denaturing HPLC to Provide Efficient Detection of Mutations Causing Familial Hypercholesterolemia
Clin Chem 2002 48: 1913-1918. [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

Ulla Derhaschnig, Anton N. Laggner, Martin Röggla, Michael M. Hirschl, Stylianos Kapiotis, Claudia Marsik, and Bernd Jilma

Evaluation of Coagulation Markers for Early Diagnosis of Acute Coronary Syndromes in the Emergency Room
Clin Chem 2002 48: 1924-1930. [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Jan Kulpa, Ewa Wójcik, Marian Reinfuss, and Leszek Kolodziejski

Carcinoembryonic Antigen, Squamous Cell Carcinoma Antigen, CYFRA 21-1, and Neuron-specific Enolase in Squamous Cell Lung Cancer Patients
Clin Chem 2002 48: 1931-1937. [Abstract] [Full Text] [PDF]  

Masato Maekawa, Motoko Inomata, Masao S. Sasaki, Akihiro Kaneko, Mineko Ushiama, Kokichi Sugano, Jun Takayama, and Takashi Kanno

Electrophoretic Variant of a Lactate Dehydrogenase Isoenzyme and Selective Promoter Methylation of the LDHA Gene in a Human Retinoblastoma Cell Line
Clin Chem 2002 48: 1938-1945. [Abstract] [Full Text] [PDF] Supplemental Data  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Shinichi Usui, Hajime Kakuuchi, Motoi Okamoto, Yuki Mizukami, and Mitsuyo Okazaki

Differential Reactivity of Two Homogeneous LDL-Cholesterol Methods to LDL and VLDL Subfractions, as Demonstrated by Ultracentrifugation and HPLC
Clin Chem 2002 48: 1946-1954. [Abstract] [Full Text] [PDF]  

John Middleton

Effect of Analytical Error on the Assessment of Cardiac Risk by the High-Sensitivity C-Reactive Protein and Lipid Screening Model
Clin Chem 2002 48: 1955-1962. [Abstract] [Full Text] [PDF] Supplemental Data  

Drug Monitoring and Toxicology:

John F. Wilson, Ian D. Watson, John Williams, Pat A. Toseland, Alison H. Thomson, Grace Sweeney, Brian L. Smith, Lance N. Sandle, John D. Ramsey, and Nigel E. Capps

Primary Standardization of Assays for Anticonvulsant Drugs: Comparison of Accuracy and Precision
Clin Chem 2002 48: 1963-1969. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Gary L. Schwartz, Arlene B. Chapman, Eric Boerwinkle, Robert M. Kisabeth, and Stephen T. Turner

Screening for Primary Aldosteronism: Implications of an Increased Plasma Aldosterone/Renin Ratio
Clin Chem 2002 48: 1919-1923. [Abstract] [Full Text] [PDF] Supplemental Data  

Automation and Analytical Techniques:

James J. Pitt, Mary Eggington, and Stephen G. Kahler

Comprehensive Screening of Urine Samples for Inborn Errors of Metabolism by Electrospray Tandem Mass Spectrometry
Clin Chem 2002 48: 1970-1980. [Abstract] [Full Text] [PDF]  

Tina Sørensen, Johanne Spenter, Irakli Jaliashvili, Michael Christiansen, Bent Nørgaard-Pedersen, and Eskild Petersen

Automated Time-resolved Immunofluorometric Assay for Toxoplasma gondii-specific IgM and IgA Antibodies: Study of More Than 130 000 Filter-Paper Blood-Spot Samples from Newborns
Clin Chem 2002 48: 1981-1986. [Abstract] [Full Text] [PDF]  

Laboratory Management:

Ari Lahti, Per Hyltoft Petersen, and James C. Boyd

Impact of Subgroup Prevalences on Partitioning of Gaussian-distributed Reference Values
Clin Chem 2002 48: 1987-1999. [Abstract] [Full Text] [PDF] Supplemental Data  

Andrew Taylor, Jurgen Angerer, Francoise Claeys, Jesper Kristiansen, Olav Mazarrasa, Antonio Menditto, Marina Patriarca, Alain Pineau, Ilse Schoeters, Christophe Sykes, Sinikka Valkonen, and Cas Weykamp

Comparison of Procedures for Evaluating Laboratory Performance in External Quality Assessment Schemes for Lead in Blood and Aluminum in Serum Demonstrates the Need for Common Quality Specifications
Clin Chem 2002 48: 2000-2007. [Abstract] [Full Text] [PDF] Supplemental Data  

General Clinical Chemistry:

Vincent Marks

False-Positive Immunoassay Results: A Multicenter Survey of Erroneous Immunoassay Results from Assays of 74 Analytes in 10 Donors from 66 Laboratories in Seven Countries
Clin Chem 2002 48: 2008-2016. [Abstract] [Full Text] [PDF]  

Diane M. Hill, Lisa J. Johnson, Paul J. Burns, Angela M. Neale, Denise M. Harmening, and Andrew C. Kenney

Effects of Temperature on Stability of Blood Homocysteine in Collection Tubes Containing 3-Deazaadenosine
Clin Chem 2002 48: 2017-2022. [Abstract] [Full Text] [PDF]  

Adel A.A. Ismail, Paul L. Walker, Julian H. Barth, Kryzsztof C. Lewandowski, Rick Jones, and William A. Burr

Wrong Biochemistry Results: Two Case Reports and Observational Study in 5310 Patients on Potentially Misleading Thyroid-stimulating Hormone and Gonadotropin Immunoassay Results
Clin Chem 2002 48: 2023-2029. [Abstract] [Full Text] [PDF]  

Pediatric Clinical Chemistry:

Glenn F. Billman, Amy B. Hughes, Golde G. Dudell, Elizabeth Waldman, Lisa M. Adcock, Dan M. Hall, Edmund N. Orsini, Jr, Adolph J. Koska, Linda J. Van Marter, Neil N. Finer, Jeff C. Kulhavy, Ronald D. Feld, and John A. Widness

Clinical Performance of an In-Line, ex Vivo Point-of-Care Monitor: A Multicenter Study
Clin Chem 2002 48: 2030-2043. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Marc H.M. Thelen, Jan van Bezu, Astrid Kok, and Ruud B.H. Schutgens

Disclosure of Hidden Free Light Chains by Immunosubtraction
Clin Chem 2002 48: 2044-2045. [Extract] [Full Text] [PDF]  

Johannes Egberts, Bob van den Heuvel, Hendrik J. Duiser, Wim van Dam, Eef G.W.M. Lentjes, and Humphrey H.H. Kanhai

Iterative, Spectrophotometric Method for Determination of Amniotic Fluid Bilirubin Concentrations: Comparison with the Liley Method
Clin Chem 2002 48: 2045-2047. [Extract] [Full Text] [PDF]  

Danielle Borrey, Evelyne Meyer, Luc Duchateau, Willy Lambert, Carlos Van Peteghem, and Andreas De Leenheer

Enzymatic Hydrolysis Improves the Sensitivity of Emit Screening for Urinary Benzodiazepines
Clin Chem 2002 48: 2047-2049. [Extract] [Full Text] [PDF]  

Charles A. Kroll, Mark J. Magera, Janice K. Helgeson, Dietrich Matern, and Piero Rinaldo

Liquid Chromatographic–Tandem Mass Spectrometric Method for the Determination of 5-Hydroxyindole-3-acetic Acid in Urine
Clin Chem 2002 48: 2049-2051. [Extract] [Full Text] [PDF]  

Federica Gemignani, Chiara Perra, Stefano Landi, Federico Canzian, Ants Kurg, Neeme Tõnisson, Renzo Galanello, Antonio Cao, Andres Metspalu, and Giovanni Romeo

Reliable Detection of ß-Thalassemia and G6PD Mutations by a DNA Microarray
Clin Chem 2002 48: 2051-2054. [Extract] [Full Text] [PDF] Supplemental Data  

Maurice M.A.L. Pelsers, Alireza Morovat, Graeme J.M. Alexander, Wim T. Hermens, Andrew K. Trull, and Jan F.C. Glatz

Liver Fatty Acid-binding Protein as a Sensitive Serum Marker of Acute Hepatocellular Damage in Liver Transplant Recipients
Clin Chem 2002 48: 2055-2057. [Extract] [Full Text] [PDF] Supplemental Data  

Don H. Catlin, Andreas Breidbach, Steve Elliott, and John Glaspy

Comparison of the Isoelectric Focusing Patterns of Darbepoetin Alfa, Recombinant Human Erythropoietin, and Endogenous Erythropoietin from Human Urine
Clin Chem 2002 48: 2057-2059. [Extract] [Full Text] [PDF]  

Harald Schennach, Christian Murr, Clara Larcher, Werner Streif, Erika Pastner, Daniela Zaknun, Diether Schönitzer, and Dietmar Fuchs

Neopterin Concentrations in Cord Blood: A Single-Cohort Study of Paired Samples from 541 Pregnant Women and Their Newborns
Clin Chem 2002 48: 2059-2061. [Extract] [Full Text] [PDF]  

Paul J.M. Hulshof, Jitske T. Brouwer, Jan Burema, and Clive E. West

Bias and Random Error in Retinol Measurements of Laboratories in Countries with Populations with Mild to Severe Vitamin A Deficiency
Clin Chem 2002 48: 2061-2063. [Extract] [Full Text] [PDF]  

Rima Obeid, Muhidien Jouma, and Wolfgang Herrmann

Cobalamin Status (Holo-Transcobalamin, Methylmalonic Acid) and Folate as Determinants of Homocysteine Concentration
Clin Chem 2002 48: 2064-2065. [Extract] [Full Text] [PDF]  

Case Reports:

Seung Ho Hong, Ward Riley, Jeffrey Rhyne, Gina Friel, and Michael Miller

Lack of Association between Increased Carotid Intima-Media Thickening and Decreased HDL-Cholesterol in a Family with a Novel ABCA1 Variant, G2265T
Clin Chem 2002 48: 2066-2070. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Julie D. Newman, C. Andrew Ramsden, and Nicholas D.H. Balazs

Monitoring Neonatal Hypoglycemia with the Accu-chek Advantage II Glucose Meter: The Cautionary Tale of Galactosemia
Clin Chem 2002 48: 2071. [Extract] [Full Text] [PDF]  

Torsten Arndt and Jürgen Kropf

Alcohol Abuse and Carbohydrate-deficient Transferrin Analysis: Are Screening and Confirmatory Analysis Required?
Clin Chem 2002 48: 2072-2074. [Extract] [Full Text] [PDF]  

Yanni Y.N. Lui, Ki-Wai Chik, and Y.M. Dennis Lo

Does Centrifugation Cause the ex Vivo Release of DNA from Blood Cells?
Clin Chem 2002 48: 2074-2076. [Extract] [Full Text] [PDF]  

Georgios Kalambokis, Margarita Kitsanou, Chryssoula Kalogera, Georgios Kolios, Konstantin Seferiadis, and Epameinondas Tsianos

Inherited Bisalbuminemia with Benign Monoclonal Gammopathy Detected by Capillary but not Agarose Gel Electrophoresis
Clin Chem 2002 48: 2076-2077. [Extract] [Full Text] [PDF]  

Jillian R. Tate, Tony Badrick, George Koumantakis, Julia M. Potter, and Peter E. Hickman

Reporting of Cardiac Troponin Concentrations
Clin Chem 2002 48: 2077-2080. [Extract] [Full Text] [PDF]  

Alan H.B. Wu and Fred S. Apple

Drs. Wu and Apple respond:
Clin Chem 2002 48: 2080-2082. [Extract] [Full Text] [PDF]  

Daniela Basso, Graziella Guariso, and Mario Plebani

Serologic Testing for Celiac Disease
Clin Chem 2002 48: 2082-2083. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

A. Ralph Henderson

The Evidence Base of Clinical Diagnosis. J.A. Knottnerus, ed. London: BMJ Books, 2001, 226 pp., $49.95, paperback. ISBN 0-7279-1571-1.
Clin Chem 2002 48: 2084-2085. [Extract] [Full Text] [PDF]  

Thomas M. Annesley

Disposition of Toxic Drugs and Chemicals in Man, 6th Edition. Randall Baselt. Foster City, CA: Biomedical Publications, 2002, 1150 pp., $135.00. ISBN 0-9626523-5-0.
Clin Chem 2002 48: 2085. [Extract] [Full Text] [PDF]  

Larry J. Kricka

Clinical Laboratory Pearls. Steven L. Jones, ed. Philadelphia: Lippincott, Williams & Wilkins, 2001, 634 pp., $39.95, paperback. ISBN 0-7817-2579-8.
Clin Chem 2002 48: 2085-2086. [Extract] [Full Text] [PDF]  

Jan Ravkilde

Markers in Cardiology: Current and Future Applications. J.E. Adams III, F.S. Apple, A.S. Jaffe, and A.H.B. Wu, eds. American Heart Association Monograph Series. Armonk, NY: Blackwell Publishing, Futura Division, 2001, 288 pp., $79.00. ISBN 0-87993-472-7.
Clin Chem 2002 48: 2086-2087. [Extract] [Full Text] [PDF]  

2002 San Diego Conference:

The San Diego Conference Cool Tools II: New Technologies for Molecular Diagnostics November 14–16, 2002 : Poster Session Abstracts
Clin Chem 2002 48: 2088-2091. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Clin Chem 2002 48: 2092. [Extract] [Full Text] [PDF]  

Accent^®:

ACCENT® Continuing Education Credit for Readers of Clinical Chemistry
Clin Chem 2002 48: 2093-2094. [Extract] [Full Text] [PDF]  

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