Editorials:

Edward W. Boyer and Michael W. Shannon

Which Drug Tests in Medical Emergencies?
Clin Chem 2003 49: 353-354. [Extract] [Full Text] [PDF]  

Nicolas von Ahsen

Labeled Primers for Mutation Scanning: Making Diagnostic Use of the Nucleobase Quenching Effect
Clin Chem 2003 49: 355-356. [Extract] [Full Text] [PDF]  

Special Reports:

Alan H.B. Wu, Charles McKay, Larry A. Broussard, Robert S. Hoffman, Tai C. Kwong, Thomas P. Moyer, Edward M. Otten, Shirley L. Welch, and Paul Wax

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Recommendations for the Use of Laboratory Tests to Support Poisoned Patients Who Present to the Emergency Department
Clin Chem 2003 49: 357-379. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Francesca Maccari, Dealba Gheduzzi, and Nicola Volpi

Anomalous Structure of Urinary Glycosaminoglycans in Patients with Pseudoxanthoma Elasticum
Clin Chem 2003 49: 380-388. [Abstract] [Full Text] [PDF] Data Supplement  

Maria Giovanna Colombo, Umberto Paradossi, Maria Grazia Andreassi, Nicoletta Botto, Samantha Manfredi, Serena Masetti, Andrea Biagini, and Aldo Clerico

Endothelial Nitric Oxide Synthase Gene Polymorphisms and Risk of Coronary Artery Disease
Clin Chem 2003 49: 389-395. [Abstract] [Full Text] [PDF]  

Cameron N. Gundry, Joshua G. Vandersteen, Gudrun H. Reed, Robert J. Pryor, Jian Chen, and Carl T. Wittwer

Amplicon Melting Analysis with Labeled Primers: A Closed-Tube Method for Differentiating Homozygotes and Heterozygotes
Clin Chem 2003 49: 396-406. [Abstract] [Full Text] [PDF]  

Michael J. Moser, David J. Marshall, Jennifer K. Grenier, Collin D. Kieffer, Anthony A. Killeen, Jerod L. Ptacin, Craig S. Richmond, Eric B. Roesch, Christopher W. Scherrer, Christopher B. Sherrill, Cris V. Van Hout, Sara J. Zanton, and James R. Prudent

Exploiting the Enzymatic Recognition of an Unnatural Base Pair to Develop a Universal Genetic Analysis System
Clin Chem 2003 49: 407-414. [Abstract] [Full Text] [PDF]  

James M. Gale, Christopher P. Romero, Gregory B. Tafoya, and Jérôme Conia

Application of Optical Trapping for Cells Grown on Plates: Optimization of PCR and Fidelity of DNA Sequencing of p53 Gene from a Single Cell
Clin Chem 2003 49: 415-424. [Abstract] [Full Text] [PDF]  

Reidun Øvstebø, Kari Bente Foss Haug, Knut Lande, and Peter Kierulf

PCR-based Calibration Curves for Studies of Quantitative Gene Expression in Human Monocytes: Development and Evaluation
Clin Chem 2003 49: 425-432. [Abstract] [Full Text] [PDF]  

Evidence-based Laboratory Medicine and Test Utilization:

Carsten Stephan, Sebastian Wesseling, Tania Schink, and Klaus Jung

Comparison of Eight Computer Programs for Receiver-Operating Characteristic Analysis
Clin Chem 2003 49: 433-439. [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Franz J. Legros, Vincent Nuyens, Michel Baudoux, Karim Zouaoui Boudjeltia, Jean-Luc Ruelle, Jacques Colicis, Francis Cantraine, and Jean-Pol Henry

Use of Capillary Zone Electrophoresis for Differentiating Excessive from Moderate Alcohol Consumption
Clin Chem 2003 49: 440-449. [Abstract] [Full Text] [PDF]  

Enrico Rossi, Leon Adams, Alexander Prins, Max Bulsara, Bastiaan de Boer, George Garas, Gerry MacQuillan, David Speers, and Gary Jeffrey

Validation of the FibroTest Biochemical Markers Score in Assessing Liver Fibrosis in Hepatitis C Patients
Clin Chem 2003 49: 450-454. [Abstract] [Full Text] [PDF]  

Hematology:

Saila Loikas, Minna Löppönen, Pauli Suominen, Jan Møller, Kerttu Irjala, Raimo Isoaho, Sirkka-Liisa Kivelä, Pertti Koskinen, and Tarja-Terttu Pelliniemi

RIA for Serum Holo-Transcobalamin: Method Evaluation in the Clinical Laboratory and Reference Interval
Clin Chem 2003 49: 455-462. [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Sam A. Margolis, Mark Vangel, and David L. Duewer

Certification of Standard Reference Material 970, Ascorbic Acid in Serum, and Analysis of Associated Interlaboratory Bias in the Measurement Process
Clin Chem 2003 49: 463-469. [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Rita De Smet, Jacqueline Van Kaer, Bruno Van Vlem, Antoine De Cubber, Philippe Brunet, Norbert Lameire, and Raymond Vanholder

Toxicity of Free p-Cresol: A Prospective and Cross-Sectional Analysis
Clin Chem 2003 49: 470-478. [Abstract] [Full Text] [PDF]  

Clinical Immunology:

D. Robert Dufour, Mageli Talastas, Maria D.A. Fernandez, Barbara Harris, Doris B. Strader, and Leonard B. Seeff

Low-Positive Anti-Hepatitis C Virus Enzyme Immunoassay Results: An Important Predictor of Low Likelihood of Hepatitis C Infection
Clin Chem 2003 49: 479-486. [Abstract] [Full Text] [PDF]  

Pediatric Clinical Chemistry:

Jean-François Benoist, Corinne Alberti, Sandrine Leclercq, Odile Rigal, Rosalie Jean-Louis, Hélene Ogier de Baulny, Dominique Porquet, and Daniel Biou

Cerebrospinal Fluid Lactate and Pyruvate Concentrations and Their Ratio in Children: Age-related Reference Intervals
Clin Chem 2003 49: 487-494. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Yanni Y.N. Lui, Kam-Sang Woo, Angela Y.M. Wang, Chung-Kwong Yeung, Philip K.T. Li, Elaine Chau, Peter Ruygrok, and Y.M. Dennis Lo

Origin of Plasma Cell-free DNA after Solid Organ Transplantation
Clin Chem 2003 49: 495-496. [Extract] [Full Text] [PDF]  

Mario Lovicu, Valeria Dessi, Antonietta Zappu, Stefano De Virgiliis, Antonio Cao, and Georgios Loudianos

Efficient Strategy for Molecular Diagnosis of Wilson Disease in the Sardinian Population
Clin Chem 2003 49: 496-498. [Extract] [Full Text] [PDF]  

Mohamed S. Rashed, Minnie Jacob, Mohamed Al-Amoudi, Zuhair Rahbeeni, Moeen A.D. Al-Sayed, Lujane Al-Ahaidib, Amal A.A. Saadallah, and Sharon Legaspi

Rapid Determination of Orotic Acid in Urine by Liquid Chromatography–Electrospray Tandem Mass Spectrometry
Clin Chem 2003 49: 499-501. [Extract] [Full Text] [PDF]  

Veronica Luzzi, Kelly Hankins, and Ann M. Gronowski

Accuracy of the Rapid Fetal Fibronectin TLi System in Predicting Preterm Delivery
Clin Chem 2003 49: 501-502. [Extract] [Full Text] [PDF]  

Rémy Sapin and Gilles Kertesz

Macroprolactin Detection by Precipitation with Protein A-Sepharose: A Rapid Screening Method Compared with Polyethylene Glycol Precipitation
Clin Chem 2003 49: 502-505. [Extract] [Full Text] [PDF]  

Alain Lavoinne, Bruno Cauliez, Hélène Eltchaninoff, Christophe Tron, and Alain Cribier

Release of Macromolecular Cardiac Troponin I Complex after Successful Percutaneous Transluminal Coronary Angioplasty in Acute Myocardial Infarction
Clin Chem 2003 49: 505-507. [Extract] [Full Text] [PDF]  

Konstanze Diefenbach, Przemyslaw M. Mrozikiewicz, Britta Brien, Olfert Landt, and Ivar Roots

Rapid Genotyping of Melanocortin-1 Receptor with Use of Fluorescence-labeled Oligonucleotides
Clin Chem 2003 49: 507-509. [Extract] [Full Text] [PDF]  

Zoltan Lukacs, Pirkko Santavuori, Angelika Keil, Robert Steinfeld, and Alfried Kohlschütter

Rapid and Simple Assay for the Determination of Tripeptidyl Peptidase and Palmitoyl Protein Thioesterase Activities in Dried Blood Spots
Clin Chem 2003 49: 509-511. [Extract] [Full Text] [PDF]  

Thomas Christian Vukovich, Stefan Mustafa, Helmut Rumpold, and Oswald Wagner

Evaluation of a Turbidimetric Denka Seiken C-Reactive Protein Assay for Cardiovascular Risk Estimation and Conventional Inflammation Diagnosis
Clin Chem 2003 49: 511-512. [Extract] [Full Text] [PDF]  

Ti Ling Chang, Manuel Salto-Tellez, Thomas P. Thamboo, Yoke Sun Lee, and Evelyn S. C. Koay

Diagnostic Validation of Capillary Electrophoresis Analysis of T-Cell Receptor -Chain Gene Rearrangements: Prediction of Malignant Transformation of Cutaneous T-Cell Lymphoproliferative Disorders
Clin Chem 2003 49: 513-515. [Extract] [Full Text] [PDF]  

Dinesh Talwar, Tara Quasim, Donald C. McMillan, John Kinsella, Cathy Williamson, and Denis St. J. O’Reilly

Pyridoxal Phosphate Decreases in Plasma but not Erythrocytes during Systemic Inflammatory Response
Clin Chem 2003 49: 515-518. [Extract] [Full Text] [PDF]  

Sarah Clark, Linda D. Youngman, Joan Sullivan, Richard Peto, and Rory Collins

Stabilization of Homocysteine in Unseparated Blood over Several Days: A Solution for Epidemiological Studies
Clin Chem 2003 49: 518-520. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Petter S. Woll, Naomi Q. Hanson, and Michael Y. Tsai

Absence of ABCA1 Mutations in Individuals with Low Serum HDL-Cholesterol
Clin Chem 2003 49: 521-522. [Extract] [Full Text] [PDF]  

Brandon Krijgsman, George Hamilton, Dimitri P. Mikhailidis, and John B. Whitfield

-Glutamyltransferase and Vascular Disease • Dr. Whitfield replies:
Clin Chem 2003 49: 522-523. [Extract] [Full Text] [PDF]  

Jaume Trapé, Josep Buxó, and Joaquim Pérez de Olaguer

Serum Concentrations of Vascular Endothelial Growth Factor in Advanced Non-Small Cell Lung Cancer
Clin Chem 2003 49: 523-525. [Extract] [Full Text] [PDF]  

Dorine W. Swinkels, Erwin Wiegerinck, Eric A.P. Steegers, and Jacques B. de Kok

Effects of Blood-Processing Protocols on Cell-free DNA Quantification in Plasma
Clin Chem 2003 49: 525-526. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Ann M. Willey

Patient’s Autonomy, Privacy and Informed Consent. H. Leino-Kilpi, M. Valimaki, M. Arndt, T. Dassen, M. Gasull, C. Lemonidou, P.A. Scott, G. Bansemir, E. Cabrera, H. Papaevangelou, and J. McFarland. Amsterdam, The Netherlands: IOS Press, 2000, 166 pp., hardcover. ISBN 1-58603-039-6.
Clin Chem 2003 49: 527. [Extract] [Full Text] [PDF]  

James F. Wesley

Toxicology: A Case-Oriented Approach. John Joseph Fenton. Boca Raton, FL: CRC Press, 2002, 584 pp., $79.95, hardcover. ISBN 0-8493-0371-0.
Clin Chem 2003 49: 527-528. [Extract] [Full Text] [PDF]  

Corrections:

Correction for Volume 49, Issue , p. 21
Clin Chem 2003 49: 528. [Extract] [Full Text] [PDF]  

Erratum:

Correction for Volume 48, Issue , p. 1668
Clin Chem 2003 49: 528. [Extract] [Full Text] [PDF]  

Abstracts for CNAPS III:

Clin Chem 2003 49: 529. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Clin Chem 2003 49: 530. [Extract] [Full Text] [PDF]  

Accent^®:

ACCENT®Continuing Education Credit for Readers of Clinical Chemistry
Clin Chem 2003 49: 531-532. [Extract] [Full Text] [PDF]  

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