Editorials:

Emanuel F. Petricoin and Lance A. Liotta

Mass Spectrometry-based Diagnostics: The Upcoming Revolution in Disease Detection
Clin Chem 2003 49: 533-534. [Extract] [Full Text] [PDF]  

Ulf-Håkan Stenman

Standardization as a Private Enterprise
Clin Chem 2003 49: 535-536. [Extract] [Full Text] [PDF]  

David A. Morrow, James A. de Lemos, Marc S. Sabatine, and Elliott M. Antman

The Search for a Biomarker of Cardiac Ischemia
Clin Chem 2003 49: 537-539. [Extract] [Full Text] [PDF]  

Mark A. Pereira and David S. Ludwig

Surveillance of Insulin Resistance in Children
Clin Chem 2003 49: 540-541. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Wen-Hwei Chou, Feng-Xiang Yan, Doris K. Robbins-Weilert, Thomas B. Ryder, Wei Wei Liu, Clotilde Perbost, Maureen Fairchild, Jose de Leon, Walter H. Koch, and Peter J. Wedlund

Comparison of Two CYP2D6 Genotyping Methods and Assessment of Genotype-Phenotype Relationships
Clin Chem 2003 49: 542-551. [Abstract] [Full Text] [PDF]  

Thomas Bonk, Andreas Humeny, Johannes Gebert, Christian Sutter, Magnus von Knebel Doeberitz, and Cord-Michael Becker

Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry-based Detection of Microsatellite Instabilities in Coding DNA Sequences: A Novel Approach to Identify DNA-Mismatch Repair-deficient Cancer Cells
Clin Chem 2003 49: 552-561. [Abstract] [Full Text] [PDF]  

Timothy H. Rainer, Lawrence K.S. Wong, Wynnie Lam, Eddie Yuen, Nicole Y.L. Lam, Constantine Metreweli, and Y.M. Dennis Lo

Prognostic Use of Circulating Plasma Nucleic Acid Concentrations in Patients with Acute Stroke
Clin Chem 2003 49: 562-569. [Abstract] [Full Text] [PDF] Supplemental Data  

Evidence-based Laboratory Medicine and Test Utilization:

John T. Philbrick and Steven Heim

The D-Dimer Test for Deep Venous Thrombosis: Gold Standards and Bias in Negative Predictive Value
Clin Chem 2003 49: 570-574. [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

Delphine Borgel, Jean-Luc Reny, David Fischelis, Sophie Gandrille, Joseph Emmerich, Jean-Noël Fiessinger, and Martine Aiach

Cleaved Protein S (PS), Total PS, Free PS, and Activated Protein C Cofactor Activity as Risk Factors for Venous Thromboembolism
Clin Chem 2003 49: 575-580. [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Nadhipuram V. Bhagavan, Ernest M. Lai, Patricia A. Rios, Jinsheng Yang, Anna M. Ortega-Lopez, Hiroko Shinoda, Stacey A.A. Honda, Carlos N. Rios, Cheryl E. Sugiyama, and Chung-Eun Ha

Evaluation of Human Serum Albumin Cobalt Binding Assay for the Assessment of Myocardial Ischemia and Myocardial Infarction
Clin Chem 2003 49: 581-585. [Abstract] [Full Text] [PDF]  

Wim G. Meijer, Sjef C.V.M. Copray, Harry Hollema, Ido P. Kema, Nynke Zwart, Ietje Mantingh-Otter, Thera P. Links, Pax H.B. Willemse, and Elisabeth G.E. de Vries

Catecholamine-Synthesizing Enzymes in Carcinoid Tumors and Pheochromocytomas
Clin Chem 2003 49: 586-593. [Abstract] [Full Text] [PDF]  

Masaki Ikemoto, Tomoko Tanaka, Yuri Takai, Hiroshi Murayama, Koichi Tanaka, and Masatoshi Fujita

New ELISA System for Myeloid-related Protein Complex (MRP8/14) and Its Clinical Significance as a Sensitive Marker for Inflammatory Responses Associated with Transplant Rejection
Clin Chem 2003 49: 594-600. [Abstract] [Full Text] [PDF]  

Alexander Haese, Ville Vaisanen, Judith A. Finlay, Kim Pettersson, Harry G. Rittenhouse, Alan W. Partin, Debra J. Bruzek, Lori J. Sokoll, Hans Lilja, and Daniel W. Chan

Standardization of Two Immunoassays for Human Glandular Kallikrein 2
Clin Chem 2003 49: 601-610. [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Mary M. Kimberly, Hubert W. Vesper, Samuel P. Caudill, Gerald R. Cooper, Nader Rifai, Francesco Dati, and Gary L. Myers

Standardization of Immunoassays for Measurement of High-Sensitivity C-reactive Protein. Phase I: Evaluation of Secondary Reference Materials
Clin Chem 2003 49: 611-616. [Abstract] [Full Text] [PDF] Data Supplement  

Automation and Analytical Techniques:

Cornelia Ottiger and Andreas R. Huber

Quantitative Urine Particle Analysis: Integrative Approach for the Optimal Combination of Automation with UF-100 and Microscopic Review with KOVA Cell Chamber
Clin Chem 2003 49: 617-623. [Abstract] [Full Text] [PDF]  

Laboratory Management:

Clement J. McDonald, Stanley M. Huff, Jeffrey G. Suico, Gilbert Hill, Dennis Leavelle, Raymond Aller, Arden Forrey, Kathy Mercer, Georges DeMoor, John Hook, Warren Williams, James Case, and Pat Maloney

LOINC, a Universal Standard for Identifying Laboratory Observations: A 5-Year Update
Clin Chem 2003 49: 624-633. [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Eric Ballot, Arnaud Bruneel, Valérie Labas, and Catherine Johanet

Identification of Rat Targets of Anti-Soluble Liver Antigen Autoantibodies by Serologic Proteome Analysis
Clin Chem 2003 49: 634-643. [Abstract] [Full Text] [PDF]  

Pediatric Clinical Chemistry:

Pierre Allard, Edgard E. Delvin, Gilles Paradis, James A. Hanley, Jennifer O’Loughlin, Claudette Lavallée, Emile Levy, and Marie Lambert

Distribution of Fasting Plasma Insulin, Free Fatty Acids, and Glucose Concentrations and of Homeostasis Model Assessment of Insulin Resistance in a Representative Sample of Quebec Children and Adolescents
Clin Chem 2003 49: 644-649. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Tobias Pischon, Gökhan S. Hotamisligil, and Eric B. Rimm

Adiponectin: Stability in Plasma over 36 Hours and Within-Person Variation over 1 Year
Clin Chem 2003 49: 650-652. [Extract] [Full Text] [PDF]  

Erik J. Giltay, Johanna M. Geleijnse, Evert G. Schouten, Martijn B. Katan, and Daan Kromhout

High Stability of Markers of Cardiovascular Risk in Blood Samples
Clin Chem 2003 49: 652-655. [Extract] [Full Text] [PDF] Data Supplement  

Ying Li, Deirdré Hahn, Xiao Yan Zhong, Peter D. Thomson, Wolfgang Holzgreve, and Sinuhe Hahn

Detection of Donor-specific DNA Polymorphisms in the Urine of Renal Transplant Recipients
Clin Chem 2003 49: 655-658. [Extract] [Full Text] [PDF]  

Carolina de Weerth, Gerard Graat, Jan K. Buitelaar, and Jos H.H. Thijssen

Measurement of Cortisol in Small Quantities of Saliva
Clin Chem 2003 49: 658-660. [Extract] [Full Text] [PDF]  

René Santer, Ralph Fingerhut, Uta Lässker, Patrick J. Wightman, David R. Fitzpatrick, Bernhard Olgemöller, and Adelbert A. Roscher

Tandem Mass Spectrometric Determination of Malonylcarnitine: Diagnosis and Neonatal Screening of Malonyl-CoA Decarboxylase Deficiency
Clin Chem 2003 49: 660-662. [Extract] [Full Text] [PDF]  

Andries J. Bakker, Bidjaiperkash Mirchi, Johannes T. Dijkstra, Freek Reitsma, Haye Syperda, and Appie Zijlstra

IFCC Method for Lactate Dehydrogenase Measurement in Heparin Plasma Is Unreliable
Clin Chem 2003 49: 662-664. [Extract] [Full Text] [PDF]  

Paula M. Ladwig, Jan H. Bergert, and Timothy S. Larson

Capillary Electrophoresis Method to Measure p-Aminohippuric Acid in Urine and Plasma for the Assessment of Renal Plasma Flow
Clin Chem 2003 49: 664-666. [Extract] [Full Text] [PDF]  

Nader Rifai and Paul M. Ridker

Population Distributions of C-reactive Protein in Apparently Healthy Men and Women in the United States: Implication for Clinical Interpretation
Clin Chem 2003 49: 666-669. [Extract] [Full Text] [PDF]  

Armin Imhof, Margit Fröhlich, Hannelore Loewel, Nicole Helbecque, Mark Woodward, Phillipe Amouyel, Gordon D.O. Lowe, and Wolfgang Koenig

Distributions of C-reactive Protein Measured by High-Sensitivity Assays in Apparently Healthy Men and Women from Different Populations in Europe
Clin Chem 2003 49: 669-672. [Extract] [Full Text] [PDF]  

Pai-Chung Gwee, Kun Tang, John M.Z. Chua, Edmund J.D. Lee, Samuel S. Chong, and Caroline G.L. Lee

Simultaneous Genotyping of Seven Single-Nucleotide Polymorphisms in the MDR1 Gene by Single-Tube Multiplex Minisequencing
Clin Chem 2003 49: 672-676. [Extract] [Full Text] [PDF]  

Srinivas Narayan, M. Giovanni Lujan, Leland B. Baskin, Sridevi Devaraj, Cynthia Rutherford, and Ishwarlal Jialal

Measurement of ß₁- and ß₂-Globulins Improves Detection of M-Spikes on High-Resolution Electrophoresis
Clin Chem 2003 49: 676-678. [Extract] [Full Text] [PDF]  

Lisa Y.S. Chan, Tse N. Leung, K.C. Allen Chan, Hok-Leung Tai, Tze K. Lau, Eric M.C. Wong, and Y.M. Dennis Lo

Serial Analysis of Fetal DNA Concentrations in Maternal Plasma in Late Pregnancy
Clin Chem 2003 49: 678-680. [Extract] [Full Text] [PDF] Data Supplement  

Vijay Jayagopal, Brian G. Keevil, Stephen L. Atkin, Paul E. Jennings, and Eric S. Kilpatrick

Paradoxical Changes in Cystatin C and Serum Creatinine in Patients with Hypo- and Hyperthyroidism
Clin Chem 2003 49: 680-681. [Extract] [Full Text] [PDF]  

Minh-Uyen Trinh, Jennifer Blake, J. Rodney Harrison, Rosemarie Gerace, Enzo Ranieri, Janice M. Fletcher, and David W. Johnson

Quantification of Glutamine in Dried Blood Spots and Plasma by Tandem Mass Spectrometry for the Biochemical Diagnosis and Monitoring of Ornithine Transcarbamylase Deficiency
Clin Chem 2003 49: 681-684. [Extract] [Full Text] [PDF] Data Supplement  

Youri E.C. Taes, Norbert H. Lameire, Marc L. De Buyzere, Amir Shoja, Guy De Backer, and Joris R. Delanghe

Exercise-induced Myocardial Ischemia Is Accompanied by Increased Serum Creatine Concentrations
Clin Chem 2003 49: 684-686. [Extract] [Full Text] [PDF]  

Earl S. Ford, Wayne H. Giles, Gary L. Myers, and David M. Mannino

Population Distribution of High-Sensitivity C-reactive Protein among US Men: Findings from National Health and Nutrition Examination Survey 1999–2000
Clin Chem 2003 49: 686-690. [Extract] [Full Text] [PDF] Data Supplement  

Daniele Del Rio, Nicoletta Pellegrini, Barbara Colombi, Marta Bianchi, Mauro Serafini, Federico Torta, Matteo Tegoni, Marilena Musci, and Furio Brighenti

Rapid Fluorimetric Method to Detect Total Plasma Malondialdehyde with Mild Derivatization Conditions
Clin Chem 2003 49: 690-692. [Extract] [Full Text] [PDF]  

Philip Paul, Josh Apgar, and Edward J. Ball

HLA-DRB1* Intron-primed Sequencing for Haploid Genotyping
Clin Chem 2003 49: 692-694. [Extract] [Full Text] [PDF]  

Case Reports:

Roger L. Bertholf, Laura M. Johannsen, Alireza Bazooband, and Vafa Mansouri

False-Positive Acetaminophen Results in a Hyperbilirubinemic Patient
Clin Chem 2003 49: 695-698. [Abstract] [Full Text] [PDF]  

History:

Louis Rosenfeld

William Prout: Early 19th Century Physician-Chemist
Clin Chem 2003 49: 699-705. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Timothy M. Reynolds, Patrick Twomey, and Anthony S. Wierzbicki

Accuracy of Cardiovascular Risk Estimation
Clin Chem 2003 49: 706-707. [Extract] [Full Text] [PDF]  

Andreas Lazar, Soenke Jan Weissenborn, Dirk Gründemann, Reinhard Berkels, Uwe Fuhr, Herbert Pfister, and Edgar Schömig

Detection of a Novel 1905CT Mutation within the Dihydropyrimidine Dehydrogenase Gene and Potential for Misclassification with the Exon 14-skipping Mutation
Clin Chem 2003 49: 707-708. [Extract] [Full Text] [PDF]  

Hans Van Vlierberghe and Joris Delanghe

Haptoglobin Polymorphism and Iron Hemostasis
Clin Chem 2003 49: 708-709. [Extract] [Full Text] [PDF]  

Veronica I. Luzzi, Mitchell G. Scott, and Ann M. Gronowski

Negative Thyrotropin Assay Interference Associated with an IgG Paraprotein
Clin Chem 2003 49: 709-710. [Extract] [Full Text] [PDF] Supplemental Data  

Book, Software, and Web Site Reviews:

Catharine M. Sturgeon

Circulating Tumor Markers of the New Millennium. Target Therapy, Early Detection, and Prognosis. James T. Wu. Washington, DC: AACC Press, 2002, 173 pp., $35.00 ($28.00 AACC members), softcover. ISBN 1-890883-73-5.
Clin Chem 2003 49: 711-712. [Extract] [Full Text] [PDF]  

David R. Jacobs

Modeling in Medical Decision Making: A Bayesian Approach. Giovanni Parmigiani. New York: John Wiley and Sons, Ltd., 2002, 266 pp., $69.95, hardcover. ISBN 0-471-98608-9.
Clin Chem 2003 49: 712-713. [Extract] [Full Text] [PDF]  

Peter Wilding

Future of Healthcare Technology. Renata G. Bushko, ed. Amsterdam, The Netherlands: OM Press, 298 pp., $80.00, hardcover. ISBN 1-58603-091-4. [From Studies in Healthcare Technology and Informatics, J.P. Christensen et al., eds. Vol. 80. Vol. 1 in the subseries.]
Clin Chem 2003 49: 713. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Clin Chem 2003 49: 714. [Extract] [Full Text] [PDF]  

Accent^®:

ACCENT® Continuing Education Credit for Readers of Clinical Chemistry
Clin Chem 2003 49: 715-716. [Extract] [Full Text] [PDF]  

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