Editorials:

David B. Sacks

Hemoglobin Variants and Hemoglobin A_1c Analysis: Problem Solved?
Clin Chem 2003 49: 1245-1247. [Extract] [Full Text] [PDF]  

Evangelos Giannitsis and Hugo A. Katus

99th Percentile and Analytical Imprecision of Troponin and Creatine Kinase-MB Mass Assays: An Objective Platform for Comparison of Assay Performance
Clin Chem 2003 49: 1248-1249. [Extract] [Full Text] [PDF]  

David A. Herold and Robert L. Fitzgerald

Immunoassays for Testosterone in Women: Better than a Guess?
Clin Chem 2003 49: 1250-1251. [Extract] [Full Text] [PDF]  

Minireview:

Jillian R. Tate, Devinder Gill, Ralph Cobcroft, and Peter E. Hickman

Practical Considerations for the Measurement of Free Light Chains in Serum
Clin Chem 2003 49: 1252-1257. [Abstract] [Full Text] [PDF]  

Review:

Thomas B. Ledue and Nader Rifai

Preanalytic and Analytic Sources of Variations in C-reactive Protein Measurement: Implications for Cardiovascular Disease Risk Assessment
Clin Chem 2003 49: 1258-1271. [Abstract] [Full Text] [PDF]  

Point/Counterpoint:

Eleftherios P. Diamandis

Proteomic Patterns in Biological Fluids: Do They Represent the Future of Cancer Diagnostics?
Clin Chem 2003 49: 1272-1275. [Extract] [Full Text] [PDF]  

Emanuel Petricoin, III and Lance A. Liotta

The Vision for a New Diagnostic Paradigm
Clin Chem 2003 49: 1276-1278. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Mónica García-Castro, Julián R. Reguero, Alberto Batalla, Beatriz Díaz-Molina, Pelayo González, Victoria Alvarez, Arturo Cortina, Gustavo I. Cubero, and Eliecer Coto

Hypertrophic Cardiomyopathy: Low Frequency of Mutations in the ß-Myosin Heavy Chain (MYH7) and Cardiac Troponin T (TNNT2) Genes among Spanish Patients
Clin Chem 2003 49: 1279-1285. [Abstract] [Full Text] [PDF]  

Nicole Y.L. Lam, Timothy H. Rainer, Lisa Y.S. Chan, Gavin M. Joynt, and Y.M. Dennis Lo

Time Course of Early and Late Changes in Plasma DNA in Trauma Patients
Clin Chem 2003 49: 1286-1291. [Abstract] [Full Text] [PDF]  

Rita Castro, Isabel Rivera, Eduard A. Struys, Erwin E.W. Jansen, Paula Ravasco, Maria Ermelinda Camilo, Henk J. Blom, Cornelis Jakobs, and Isabel Tavares de Almeida

Increased Homocysteine and S-Adenosylhomocysteine Concentrations and DNA Hypomethylation in Vascular Disease
Clin Chem 2003 49: 1292-1296. [Abstract] [Full Text] [PDF]  

Tina Yen, Brian N. Nightingale, Jennifer C. Burns, David R. Sullivan, and Peter M. Stewart

Butyrylcholinesterase (BCHE) Genotyping for Post-Succinylcholine Apnea in an Australian Population
Clin Chem 2003 49: 1297-1308. [Abstract] [Full Text] [PDF] Data Supplement  

Béatrice Chabi, Bénédicte Mousson de Camaret, Hervé Duborjal, Jean-Paul Issartel, and Georges Stepien

Quantification of Mitochondrial DNA Deletion, Depletion, and Overreplication: Application to Diagnosis
Clin Chem 2003 49: 1309-1317. [Abstract] [Full Text] [PDF]  

David E. Malehorn, Cheryl A. Telmer, Sherri B. McEwen, Jiyan An, Ashley D. Kinsey, Adam C. Retchless, Christopher Mason, William M. Vieta, and Jonathan W. Jarvik

Detection of Cystic Fibrosis Mutations by Peptide Mass Signature Genotyping
Clin Chem 2003 49: 1318-1330. [Abstract] [Full Text] [PDF] Supplemental Data  

Proteomics and Protein Markers:

Fred S. Apple, Heidi E. Quist, Patrick J. Doyle, Angela P. Otto, and MaryAnn M. Murakami

Plasma 99th Percentile Reference Limits for Cardiac Troponin and Creatine Kinase MB Mass for Use with European Society of Cardiology/American College of Cardiology Consensus Recommendations
Clin Chem 2003 49: 1331-1336. [Abstract] [Full Text] [PDF] Data Supplement  

Urban Alehagen, Göran Lindstedt, Henry Eriksson, and Ulf Dahlström

Utility of the Amino-Terminal Fragment of Pro-Brain Natriuretic Peptide in Plasma for the Evaluation of Cardiac Dysfunction in Elderly Patients in Primary Health Care
Clin Chem 2003 49: 1337-1346. [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Ling Liu, Shui-Ping Zhao, Yan-Chun Cheng, and Yu-Ling Li

Xuezhikang Decreases Serum Lipoprotein(a) and C-reactive Protein Concentrations in Patients with Coronary Heart Disease
Clin Chem 2003 49: 1347-1352. [Abstract] [Full Text] [PDF]  

Earl S. Ford, Wayne H. Giles, Gary L. Myers, Nader Rifai, Paul M. Ridker, and David M. Mannino

C-reactive Protein Concentration Distribution among US Children and Young Adults: Findings from the National Health and Nutrition Examination Survey, 1999–2000
Clin Chem 2003 49: 1353-1357. [Abstract] [Full Text] [PDF]  

Duk-Hee Lee, David R. Jacobs, Jr, Myron Gross, Catarina I. Kiefe, Jeffrey Roseman, Cora E. Lewis, and Michael Steffes

-Glutamyltransferase Is a Predictor of Incident Diabetes and Hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Clin Chem 2003 49: 1358-1366. [Abstract] [Full Text] [PDF]  

Hematology:

Ralph Carmel

Mild Transcobalamin I (Haptocorrin) Deficiency and Low Serum Cobalamin Concentrations
Clin Chem 2003 49: 1367-1374. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Jojanneke H.J. Huck, Eduard A. Struys, Nanda M. Verhoeven, Cornelis Jakobs, and Marjo S. van der Knaap

Profiling of Pentose Phosphate Pathway Intermediates in Blood Spots by Tandem Mass Spectrometry: Application to Transaldolase Deficiency
Clin Chem 2003 49: 1375-1380. [Abstract] [Full Text] [PDF]  

Joëlle Taieb, Bruno Mathian, Françoise Millot, Marie-Claude Patricot, Elisabeth Mathieu, Nicole Queyrel, Isabelle Lacroix, Claude Somma-Delpero, and Philippe Boudou

Testosterone Measured by 10 Immunoassays and by Isotope-Dilution Gas Chromatography–Mass Spectrometry in Sera from 116 Men, Women, and Children
Clin Chem 2003 49: 1381-1395. [Abstract] [Full Text] [PDF] Data Supplements  

Technical Briefs:

David A. Morrow, Nader Rifai, Marc S. Sabatine, Shake Ayanian, Sabina A. Murphy, James A. de Lemos, Eugene Braunwald, and Christopher P. Cannon

Evaluation of the AccuTnI Cardiac Troponin I Assay for Risk Assessment in Acute Coronary Syndromes
Clin Chem 2003 49: 1396-1398. [Extract] [Full Text] [PDF]  

Virgile Richard, Alexander Luchin, Romulo M. Brena, Christoph Plass, and Thomas J. Rosol

Quantitative Evaluation of Alternative Promoter Usage and 3' Splice Variants for Parathyroid Hormone-related Protein by Real-Time Reverse Transcription-PCR
Clin Chem 2003 49: 1398-1402. [Extract] [Full Text] [PDF] Data Supplement  

Carol M. Preissner, Philip J. Wolhuter, John W. Sistrunk, Henry A. Homburger, and John C. Morris, III

Comparison of Thyrotropin-Receptor Antibodies Measured by Four Commercially Available Methods with a Bioassay That Uses Fisher Rat Thyroid Cells
Clin Chem 2003 49: 1402-1404. [Extract] [Full Text] [PDF]  

Heike Görgens, Peter Schwarz, Jan Schulze, and Hans K. Schackert

LightCycler Assay in the Analysis of Haplotypes of the Type 2 Diabetes Susceptibility Gene CAPN10
Clin Chem 2003 49: 1405-1408. [Extract] [Full Text] [PDF]  

Maarten O. van Aken, Johannes A. Romijn, Johannes A. Miltenburg, and Eef G.W.M. Lentjes

Automated Measurement of Salivary Cortisol
Clin Chem 2003 49: 1408-1409. [Extract] [Full Text] [PDF]  

Anupam Basu, Tulsidas G. Shrivastav, and Kiran P. Kariya

Preparation of Enzyme Conjugate through Adipic Acid Dihydrazide as Linker and Its Use in Immunoassays
Clin Chem 2003 49: 1410-1412. [Extract] [Full Text] [PDF]  

Ulrich Friess, Alexander Beck, Elisabeth Kohne, Rainer Lehmann, Sylvia Koch, Hans-Ulrich Haring, Reinhold-Michael Schmuelling, and Erwin Schleicher

Novel Hemoglobin Variant [ß66(E10) LysAsn], with Decreased Oxygen Affinity, Causes Falsely Low Hemoglobin A_1c Values by HPLC
Clin Chem 2003 49: 1412-1415. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Michelle M. Murphy, Joan D. Fernandez-Ballart, Stuart J. Moat, Pauline A.L. Ashfield-Watt, Hilary J. Powers, Robert G. Newcombe, and Ian F.W. McDowell

Folic Acid Supplementation and Riboflavin Status • The authors of the article cited in the above letter respond:
Clin Chem 2003 49: 1416-1417. [Extract] [Full Text] [PDF]  

EeMun Lim, Peter Bennett, and John Beilby

Sample Preparation in Patients Receiving Uric Acid Oxidase (Rasburicase) Therapy
Clin Chem 2003 49: 1417-1419. [Extract] [Full Text] [PDF]  

Godelieve Mariën, Guido Vranken, Michel Demuylder, Norbert Blanckaert, Xavier Bossuyt, Kevin Day, and Jack Zakowski

Clinical Capillary Zone Electrophoresis of Serum Proteins: Balancing High Sensitivity and High Specificity • Representatives of Beckman Coulter respond:
Clin Chem 2003 49: 1419-1421. [Extract] [Full Text] [PDF]  

Anna M. Halldorsdottir, Mary O. Carayannopoulos, Mary Scrivner, and Ann M. Gronowski

Method Evaluation for Total ß-Human Chorionic Gonadotropin Using Urine and the ADVIA Centaur
Clin Chem 2003 49: 1421-1422. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Mark A. Arnold

IR Spectroscopy: An Introduction Helmut Gunzler and Hans-Ulrich. Weinheim, Germany: Wiley, 2002, 376 pp., $45.00. ISBN 3-527-28896-1.
Clin Chem 2003 49: 1423. [Extract] [Full Text] [PDF]  

Vincent Marks

Point of Care Testing. James H. Nichols, ed. New York: Marcel Decker, Inc., 2003, 512 pp., $185.00, hardcover. ISBN 0-8247-0868-7.
Clin Chem 2003 49: 1423-1424. [Extract] [Full Text] [PDF]  

Celia J. Menendez-Botet

Principles & Practices of Point-of-Care Testing. Gerald J. Kost, ed. Philadelphia: Lippincott Williams & Wilkins, 2002, 672 pp., $95.00, cloth. ISBN: 0-7817-3156-9
Clin Chem 2003 49: 1424-1425. [Extract] [Full Text] [PDF]  

Accent:

ACCENT® Continuing Education Credit for Readers of Clinical Chemistry
Clin Chem 2003 49: 1426-1427. [Extract] [Full Text] [PDF]  

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