Editorials:

Ivy H.N. Wong

The Sporadic Nature of Shedding Cells in Blood: Multiple RNA Diagnostic Testing and Prognostication of Cancer Progression
Clin Chem 2003 49: 1429-1431. [Extract] [Full Text] [PDF]  

Marco Cattaneo

Homocysteine and the Risk of Intrauterine Growth Retardation
Clin Chem 2003 49: 1432-1433. [Extract] [Full Text] [PDF]  

Michael Fahie-Wilson

In Hyperprolactinemia, Testing for Macroprolactin Is Essential
Clin Chem 2003 49: 1434-1436. [Extract] [Full Text] [PDF]  

Review:

Mariska A.J. van Dijk, Johannes B. Reitsma, Johan C. Fischer, and Gerard T.B. Sanders

Indications for Requesting Laboratory Tests for Concurrent Diseases in Patients with Carpal Tunnel Syndrome: A Systematic Review
Clin Chem 2003 49: 1437-1444. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Cees B.M. Oudejans, Attie T.J.J. Go, Allerdien Visser, Monique A.M. Mulders, Bart A. Westerman, Marinus A. Blankenstein, and John M.G. van Vugt

Detection of Chromosome 21-encoded mRNA of Placental Origin in Maternal Plasma
Clin Chem 2003 49: 1445-1449. [Abstract] [Full Text] [PDF]  

Jolanta Szenajch, Bogdan Jasinski, Agnieszka Synowiec, Jadwiga Kulik, Malgorzata Chomicka, Jerzy Struzyna, Zbigniew Nowecki, Piotr Rutkowski, Wlodzimierz Ruka, Witold Kupsc, Janusz A. Siedlecki, and Wieslaw Wiktor-Jedrzejczak

Prognostic Value of Multiple Reverse Transcription-PCR Tyrosinase Testing for Circulating Neoplastic Cells in Malignant Melanoma
Clin Chem 2003 49: 1450-1457. [Abstract] [Full Text] [PDF]  

Denis Schamhart, Johannes Swinnen, Karl-Heinz Kurth, Alex Westerhof, Ron Kusters, Holger Borchers, and Cora Sternberg

Numeric Definition of the Clinical Performance of the Nested Reverse Transcription-PCR for Detection of Hematogenous Epithelial Cells and Correction for Specific mRNA of Non-Target Cell Origin as Evaluated for Prostate Cancer Cells
Clin Chem 2003 49: 1458-1466. [Abstract] [Full Text] [PDF]  

Marcy B. Grace, Christopher B. McLeland, Steven J. Gagliardi, Jeffrey M. Smith, William E. Jackson, III, and William F. Blakely

Development and Assessment of a Quantitative Reverse Transcription-PCR Assay for Simultaneous Measurement of Four Amplicons
Clin Chem 2003 49: 1467-1475. [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

Claire Infante-Rivard, Georges-Etienne Rivard, Robert Gauthier, and Yves Théorêt

Unexpected Relationship between Plasma Homocysteine and Intrauterine Growth Restriction
Clin Chem 2003 49: 1476-1482. [Abstract] [Full Text] [PDF]  

John E. Schrecengost, Robin D. LeGallo, James C. Boyd, Karel G.M. Moons, Steven L. Gonias, C. Edward Rose, Jr, and David E. Bruns

Comparison of Diagnostic Accuracies in Outpatients and Hospitalized Patients of D-Dimer Testing for the Evaluation of Suspected Pulmonary Embolism
Clin Chem 2003 49: 1483-1490. [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Natàlia Ferré, Jordi Camps, Joan Fernández-Ballart, Victoria Arija, Michelle M. Murphy, Santiago Ceruelo, Elisabet Biarnés, Elisabet Vilella, Mónica Tous, and Jorge Joven

Regulation of Serum Paraoxonase Activity by Genetic, Nutritional, and Lifestyle Factors in the General Population
Clin Chem 2003 49: 1491-1497. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Insook Kim, Allan J. Barnes, Raf Schepers, Eric T. Moolchan, Lisa Wilson, Gail Cooper, Claire Reid, Chris Hand, and Marilyn A. Huestis

Sensitivity and Specificity of the Cozart Microplate EIA Cocaine Oral Fluid at Proposed Screening and Confirmation Cutoffs
Clin Chem 2003 49: 1498-1503. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Abdulwahab M. Suliman, Thomas P. Smith, James Gibney, and T. Joseph McKenna

Frequent Misdiagnosis and Mismanagement of Hyperprolactinemic Patients before the Introduction of Macroprolactin Screening: Application of a New Strict Laboratory Definition of Macroprolactinemia
Clin Chem 2003 49: 1504-1509. [Abstract] [Full Text] [PDF]  

Other Areas of Clinical Chemistry:

Snjezana Rothkrantz-Kos, Marja P. van Dieijen-Visser, Paul G.H. Mulder, and Marjolein Drent

Potential Usefulness of Inflammatory Markers to Monitor Respiratory Functional Impairment in Sarcoidosis
Clin Chem 2003 49: 1510-1517. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Masato Maekawa, Terumi Taniguchi, Jinko Ishikawa, Haruhiko Sugimura, Kokichi Sugano, and Takashi Kanno

Promoter Hypermethylation in Cancer Silences LDHB, Eliminating Lactate Dehydrogenase Isoenzymes 1-4
Clin Chem 2003 49: 1518-1520. [Extract] [Full Text] [PDF]  

Ursula Turpeinen, Ulla Hohenthal, and Ulf-Håkan Stenman

Determination of 25-Hydroxyvitamin D in Serum by HPLC and Immunoassay
Clin Chem 2003 49: 1521-1524. [Extract] [Full Text] [PDF]  

Robert L. Raffaï, Ruth McPherson, Karl H. Weisgraber, Thomas L. Innerarity, Eric Rassart, Thomas P. Bersot, and Ross W. Milne

Antibody Phenotyping Test for the Human Apolipoprotein E2 Isoform
Clin Chem 2003 49: 1524-1526. [Extract] [Full Text] [PDF]  

Maddalena Smid, Silvia Galbiati, Antonia Vassallo, Dania Gambini, Augusto Ferrari, Gabriella Restagno, Elsa Viora, Marco Pagliano, Stefano Calza, Maurizio Ferrari, and Laura Cremonesi

Fetal DNA in Maternal Plasma in Twin Pregnancies
Clin Chem 2003 49: 1526-1528. [Extract] [Full Text] [PDF]  

Isabelle Fleury, Patrick Beaulieu, Melanie Primeau, Damian Labuda, Daniel Sinnett, and Maja Krajinovic

Characterization of the BclI Polymorphism in the Glucocorticoid Receptor Gene
Clin Chem 2003 49: 1528-1531. [Extract] [Full Text] [PDF]  

Rémy Sapin and Michèle d’Herbomez

Free Thyroxine Measured by Equilibrium Dialysis and Nine Immunoassays in Sera with Various Serum Thyroxine-binding Capacities
Clin Chem 2003 49: 1531-1535. [Extract] [Full Text] [PDF]  

Shingo Yamada, Keiichi Inoue, Keiko Yakabe, Hitoshi Imaizumi, and Ikuro Maruyama

High Mobility Group Protein 1 (HMGB1) Quantified by ELISA with a Monoclonal Antibody That Does Not Cross-React with HMGB2
Clin Chem 2003 49: 1535-1537. [Extract] [Full Text] [PDF]  

Roberta Bordoni, Bianca Castiglioni, Alessandra Mezzelani, Ermanno Rizzi, Andrea Frosini, Clarissa Consolandi, Luigi Rossi Bernardi, Cristina Battaglia, and Gianluca De Bellis

Apolipoprotein E and Transferrin Genotyping by Ligation Detection Reaction and Universal Array
Clin Chem 2003 49: 1537-1540. [Extract] [Full Text] [PDF]  

Masatoshi Jimbo, Akihiko Sekizawa, Yumi Sugito, Ryu Matsuoka, Kiyotake Ichizuka, Hiroshi Saito, and Takashi Okai

Placenta Increta: Postpartum Monitoring of Plasma Cell-free Fetal DNA
Clin Chem 2003 49: 1540-1541. [Extract] [Full Text] [PDF]  

Andrew McCaddon, Peter Hudson, Cherie McCracken, Richard Ellis, and Anne McCaddon

Biological Variation of Holo-Transcobalamin in Elderly Individuals
Clin Chem 2003 49: 1542-1544. [Extract] [Full Text] [PDF]  

Anne Ponthieux, Bernard Herbeth, Suzanne Droesch, Daniel Lambert, and Sophie Visvikis

Age- and Sex-related Reference Values for Serum Adhesion Molecule Concentrations in Healthy Individuals: Intercellular Adhesion Molecule-1 and E-, P-, and L-Selectin
Clin Chem 2003 49: 1544-1546. [Extract] [Full Text] [PDF]  

Ferdinando Mannello and Maurizio Sebastiani

Zymographic Analyses and Measurement of Matrix Metalloproteinase-2 and -9 in Nipple Aspirate Fluids
Clin Chem 2003 49: 1546-1550. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Lynne Lennard, Maria Shipkova, Victor William Armstrong, Eberhard Wieland, and Michael Oellerich

Commentary on: Differences in Nucleotide Hydrolysis Contribute to the Differences between Erythrocyte 6-Thioguanine Nucleotide Concentrations Determined by Two Widely Used Methods • The authors of the article cited above respond:
Clin Chem 2003 49: 1551-1552. [Extract] [Full Text] [PDF]  

Concetta Prontera, Michele Emdin, Gian Carlo Zucchelli, Andrea Ripoli, Claudio Passino, and Aldo Clerico

Natriuretic Peptides (NPs): Automated Electrochemiluminescent Immunoassay for N-Terminal pro-BNP Compared with IRMAs for ANP and BNP in Heart Failure Patients and Healthy Individuals
Clin Chem 2003 49: 1552-1554. [Extract] [Full Text] [PDF]  

GianVico Melzi d’Eril, Tiziana Tagnochetti, Andrea Nauti, Catherine Klersy, Antonia Papalia, Giovanbattista Vadacca, Remigio Moratti, and Giampaolo Merlini

Biological Variation of N-Terminal Pro-Brain Natriuretic Peptide in Healthy Individuals
Clin Chem 2003 49: 1554-1555. [Extract] [Full Text] [PDF]  

Paul F.J. Koppens, Herman J. Degenhart, and Hsien-Hsiung Lee

PCR-based Detection of CYP21 Deletions • One of the authors of the Technical Brief cited above responds:
Clin Chem 2003 49: 1555-1557. [Extract] [Full Text] [PDF]  

Rian W. Roelofs, Tom Sprong, Jacques B. de Kok, and Dorine W. Swinkels

PCR-Restriction Fragment Length Polymorphism Method to Detect the X/Y Polymorphism in the Promoter Site of the Mannose-binding Lectin Gene
Clin Chem 2003 49: 1557-1558. [Extract] [Full Text] [PDF]  

Jan G. den Hollander, Raymond W. Wulkan, Mart J. Mantel, and Arie Berghout

Is Cystatin C a Marker of Glomerular Filtration Rate in Thyroid Dysfunction?
Clin Chem 2003 49: 1558-1559. [Extract] [Full Text] [PDF]  

Massimo Gai, Giorgina B. Piccoli, Giuseppe P. Segoloni, and Giacomo Lanfranco

Microscopic Urinalysis and Automated Flow Cytometry in a Nephrology Laboratory
Clin Chem 2003 49: 1559-1560. [Extract] [Full Text] [PDF]  

William L. Nowatzke and Thomas G. Cole

Stability of N-Terminal Pro-Brain Natriuretic Peptide after Storage Frozen for One Year and after Multiple Freeze-Thaw Cycles
Clin Chem 2003 49: 1560-1562. [Extract] [Full Text] [PDF]  

Shan Yuan, Claudia Bien, Mark H. Wener, Peter Simkin, Petrie M. Rainey, and Michael L. Astion

Repeat Examination of Synovial Fluid for Crystals: Is It Useful?
Clin Chem 2003 49: 1562-1563. [Extract] [Full Text] [PDF]  

Manfred Rauh and Andreas Koch

Plasma N-Terminal Pro-B-Type Natriuretic Peptide Concentrations in a Control Population of Infants and Children
Clin Chem 2003 49: 1563-1564. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

James A. Cowan

Bioinorganic Chemistry: A Short Course. Rosette M. Roat-Malone. Hoboken, NJ: Wiley-Interscience, A John Wiley & Sons Inc. Publication, 2002, 366 pp., $89.95, softcover. ISBN 0-471-15976-X.
Clin Chem 2003 49: 1565-1566. [Extract] [Full Text] [PDF]  

William Clarke

Mosby’s Diagnostic and Laboratory Test Reference, Sixth Edition. Kathleen D. Pagana and Timothy J. Pagana. St. Louis, MO: Mosby, An Affiliate of Elsevier Science, 2003, 1053 pp., $34.95, softcover. ISBN 0-323-02049-6.
Clin Chem 2003 49: 1565. [Extract] [Full Text] [PDF]  

Moshe Szyf

The Epigenome: Molecular Hide and Seek. Stephan Beck and Alexander Olek, editors. Weinheim, Germany: Wiley-VCH GmbH Co. KGaA, 2003, 188 pp., $35.00, softcover. ISBN 3-527-30494-0.
Clin Chem 2003 49: 1566-1567. [Extract] [Full Text] [PDF]  

Emily S. Winn-Deen

Pharmacogenomics: Social, Ethical, and Clinical Dimensions. Mark A. Rothstein, editor. Hoboken, NJ: John Wiley & Sons, Inc., 2003, 380 pp., $59.95, hardcover. ISBN 0-471-22769-2.
Clin Chem 2003 49: 1567. [Extract] [Full Text] [PDF]  

Robert Rej

WebCitings
Clin Chem 2003 49: 1567-1568. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Clin Chem 2003 49: 1569-1570. [Extract] [Full Text] [PDF]  

Accent:

ACCENT® Continuing Education Credit for Readers of Clinical Chemistry
Clin Chem 2003 49: 1571-1572. [Extract] [Full Text] [PDF]  

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