Editorials:

David E. Bruns and Robert Rej

Fifty Years of Clinical Chemistry
Clin Chem 2004 50: 1-2. [Extract] [Full Text] [PDF]  

Review:

Helga Refsum, A. David Smith, Per M. Ueland, Ebba Nexo, Robert Clarke, Joseph McPartlin, Carole Johnston, Frode Engbaek, Jørn Schneede, Catherine McPartlin, and John M. Scott

Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion
Clin Chem 2004 50: 3-32. [Abstract] [Full Text] [PDF]  

Aldo Clerico and Michele Emdin

Diagnostic Accuracy and Prognostic Relevance of the Measurement of Cardiac Natriuretic Peptides: A Review
Clin Chem 2004 50: 33-50. Published online November 18, 2003; 10.1373/clinchem.2003.024760 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Soi-Moi Chye, Shiu-Ru Lin, Ya-Lei Chen, Lee-Yi Chung, and Chuan-Min Yen

Immuno-PCR for Detection of Antigen to Angiostrongylus cantonensis Circulating Fifth-Stage Worms
Clin Chem 2004 50: 51-57. [Abstract] [Full Text] [PDF]  

Udo F.H. Engelke, Maria L.F. Liebrand-van Sambeek, Jan G.N. de Jong, Jules G. Leroy, Éva Morava, Jan A.M. Smeitink, and Ron A. Wevers

N-Acetylated Metabolites in Urine: Proton Nuclear Magnetic Resonance Spectroscopic Study on Patients with Inborn Errors of Metabolism
Clin Chem 2004 50: 58-66. Published online November 18, 2003; 10.1373/clinchem.2003.020214 [Abstract] [Full Text] [PDF]  

Leo L.M. Poon, Kwok Hung Chan, On Kei Wong, Timothy K.W. Cheung, Iris Ng, Bojian Zheng, Wing Hong Seto, Kwok Yung Yuen, Yi Guan, and Joseph S.M. Peiris

Detection of SARS Coronavirus in Patients with Severe Acute Respiratory Syndrome by Conventional and Real-Time Quantitative Reverse Transcription-PCR Assays
Clin Chem 2004 50: 67-72. [Abstract] [Full Text] [PDF]  

Barbara Foglieni, Laura Cremonesi, Maurizio Travi, Anna Ravani, Antonino Giambona, Maria Cristina Rosatelli, Chiara Perra, Paolo Fortina, and Maurizio Ferrari

ß-Thalassemia Microelectronic Chip: A Fast and Accurate Method for Mutation Detection
Clin Chem 2004 50: 73-79. [Abstract] [Full Text] [PDF] Data Supplement  

John Greg Howe, Jill Crouch, Dennis Cooper, and Brian R. Smith

Real-Time Quantitative Reverse Transcription-PCR for Cyclin D1 mRNA in Blood, Marrow, and Tissue Specimens for Diagnosis of Mantle Cell Lymphoma
Clin Chem 2004 50: 80-87. Published online November 21, 2003; 10.1373/clinchem.2003.024695 [Abstract] [Full Text] [PDF] Data Supplement  

K.C. Allen Chan, Jun Zhang, Angela B.Y. Hui, Nathalie Wong, Tze K. Lau, Tse N. Leung, Kwok-Wai Lo, Dolly W.S. Huang, and Y.M. Dennis Lo

Size Distributions of Maternal and Fetal DNA in Maternal Plasma
Clin Chem 2004 50: 88-92. [Abstract] [Full Text] [PDF]  

Mercè Garcia-Barceló, Mai-Har Sham, Wing-Shan Lee, Vincent Chi-Hang Lui, Benedict Ling-Sze Chen, Kenneth Kak-Yuen Wong, Joyce Suet-Wan Wong, and Paul Kwong-Hang Tam

Highly Recurrent RET Mutations and Novel Mutations in Genes of the Receptor Tyrosine Kinase and Endothelin Receptor B Pathways in Chinese Patients with Sporadic Hirschsprung Disease
Clin Chem 2004 50: 93-100. Published online November 18, 2003; 10.1373/clinchem.2003.022061 [Abstract] [Full Text] [PDF]  

Hubert A. Carchon, Roland Chevigné, Jean-Bernard Falmagne, and Jaak Jaeken

Diagnosis of Congenital Disorders of Glycosylation by Capillary Zone Electrophoresis of Serum Transferrin
Clin Chem 2004 50: 101-111. Published online November 18, 2003; 10.1373/clinchem.2003.021568 [Abstract] [Full Text] [PDF]  

Evidence-based Laboratory Medicine and Test Utilization:

Detlef Ritter, Paul A. Lee, James F. Taylor, Leo Hsu, Jerome D. Cohen, Hyung D. Chung, and Katherine S. Virgo

Troponin I in Patients without Chest Pain
Clin Chem 2004 50: 112-119. [Abstract] [Full Text] [PDF]  

Ramon Martí, Antonella Spinazzola, Saba Tadesse, Ichizo Nishino, Yutaka Nishigaki, and Michio Hirano

Definitive Diagnosis of Mitochondrial Neurogastrointestinal Encephalomyopathy by Biochemical Assays
Clin Chem 2004 50: 120-124. Published online November 18, 2003; 10.1373/clinchem.2003.026179 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Ping Wu, Lei Zhu, Ulf-Hakan Stenman, and Jari Leinonen

Immunopeptidometric Assay for Enzymatically Active Prostate-Specific Antigen
Clin Chem 2004 50: 125-129. Published online November 18, 2003; 10.1373/clinchem.2003.026146 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Alex J. MacGregor, J. Ruth Gallimore, Tim D. Spector, and Mark B. Pepys

Genetic Effects on Baseline Values of C-Reactive Protein and Serum Amyloid A Protein: A Comparison of Monozygotic and Dizygotic Twins
Clin Chem 2004 50: 130-134. Published online November 18, 2003; 10.1373/clinchem.2003.028258 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Jean-Claude Lavoie, Philippe Chessex, Thérèse Rouleau, Diane Migneault, and Blandine Comte

Light-Induced Byproducts of Vitamin C in Multivitamin Solutions
Clin Chem 2004 50: 135-140. [Abstract] [Full Text] [PDF]  

Christoph Härtel, Nina Schumacher, Lutz Fricke, Brigitte Ebel, Holger Kirchner, and Michael Müller-Steinhardt

Sensitivity of Whole-Blood T Lymphocytes in Individual Patients to Tacrolimus (FK 506): Impact of Interleukin-2 mRNA Expression as Surrogate Measure of Immunosuppressive Effect
Clin Chem 2004 50: 141-151. [Abstract] [Full Text] [PDF]  

Frank Streit, Maria Shipkova, Victor William Armstrong, and Michael Oellerich

Validation of a Rapid and Sensitive Liquid Chromatography–Tandem Mass Spectrometry Method for Free and Total Mycophenolic Acid
Clin Chem 2004 50: 152-159. Published online November 18, 2003; 10.1373/clinchem.2003.024323 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Zhimin Cao, Thomas A. Swift, Clint A. West, Thomas G. Rosano, and Robert Rej

Immunoassay of Estradiol: Unanticipated Suppression by Unconjugated Estriol
Clin Chem 2004 50: 160-165. [Abstract] [Full Text] [PDF]  

Wieland Hoelzel, Cas Weykamp, Jan-Olof Jeppsson, Kor Miedema, John R. Barr, Ian Goodall, Tadao Hoshino, W. Garry John, Uwe Kobold, Randie Little, Andrea Mosca, Pierluigi Mauri, Rita Paroni, Fransiscus Susanto, Izumu Takei, Linda Thienpont, Masao Umemoto, and Hsiao-Mei Wiedmeyer

IFCC Reference System for Measurement of Hemoglobin A_1c in Human Blood and the National Standardization Schemes in the United States, Japan, and Sweden: A Method-Comparison Study
Clin Chem 2004 50: 166-174. [Abstract] [Full Text] [PDF]  

Point-of-Care Testing:

Jonathon T. Olesberg, Mark A. Arnold, and Michael J. Flanigan

Online Measurement of Urea Concentration in Spent Dialysate during Hemodialysis
Clin Chem 2004 50: 175-181. [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Glenn E. Palomaki, George J. Knight, Marie M. Roberson, George C. Cunningham, Jo Ellen Lee, Charles M. Strom, and Raj Pandian

Invasive Trophoblast Antigen (Hyperglycosylated Human Chorionic Gonadotropin) in Second-Trimester Maternal Urine as a Marker for Down Syndrome: Preliminary Results of an Observational Study on Fresh Samples
Clin Chem 2004 50: 182-189. [Abstract] [Full Text] [PDF]  

Stanley F. Lo, Basil T. Doumas, and Edward R. Ashwood

Performance of Bilirubin Determinations in US Laboratories—Revisited
Clin Chem 2004 50: 190-194. Published online November 18, 2003; 10.1373/clinchem.2003.019216 [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Georg Endler, Claudia Marsik, Christian Joukhadar, Rodrig Marculescu, Florian Mayr, Christine Mannhalter, Oswald F. Wagner, and Bernd Jilma

The Interleukin-6 G(-174)C Promoter Polymorphism Does Not Determine Plasma Interleukin-6 Concentrations in Experimental Endotoxemia in Humans
Clin Chem 2004 50: 195-200. [Abstract] [Full Text] [PDF]  

Technical Briefs:

Dimitrios Tsikas, Alexander Wolf, and Jürgen C. Frölich

Simplified HPLC Method for Urinary and Circulating Creatinine
Clin Chem 2004 50: 201-203. [Extract] [Full Text] [PDF]  

Françoise Révillion, Alain Verdière, Joëlle Fournier, Louis Hornez, and Jean-Philippe Peyrat

Multiplex Single-Nucleotide Primer Extension Analysis To Simultaneously Detect Eleven BRCA1 Mutations In Breast Cancer Families
Clin Chem 2004 50: 203-206. [Extract] [Full Text] [PDF] Data Supplement  

Timothy H. Rainer, Nicole Y.L. Lam, Nancy B.Y. Tsui, Enders K.O. Ng, Rossa W.K. Chiu, Gavin M. Joynt, and Y.M. Dennis Lo

Effects of Filtration on Glyceraldehyde-3-Phosphate Dehydrogenase mRNA in the Plasma of Trauma Patients and Healthy Individuals
Clin Chem 2004 50: 206-208. [Extract] [Full Text] [PDF] Data Supplement  

Chantelle J. Bennetto, Jennifer R. King, Michele L. Turner, Jeffrey S.A. Stringer, and Edward P. Acosta

Effects of Concentration and Temperature on the Stability of Nevirapine in Whole Blood and Serum
Clin Chem 2004 50: 209-211. [Extract] [Full Text] [PDF]  

Mengjun Wang, Timothy M. Block, Laura Steel, Dean E. Brenner, and Ying-Hsiu Su

Preferential Isolation of Fragmented DNA Enhances the Detection of Circulating Mutated k-ras DNA
Clin Chem 2004 50: 211-213. [Extract] [Full Text] [PDF]  

Nicole Y.L. Lam, Timothy H. Rainer, Rossa W.K. Chiu, Gavin M. Joynt, and Y.M. Dennis Lo

Plasma Mitochondrial DNA Concentrations after Trauma
Clin Chem 2004 50: 213-216. [Extract] [Full Text] [PDF]  

Valentina Baldas, Alberto Tommasini, Daniela Santon, Tarcisio Not, Tania Gerarduzzi, Gabriella Clarich, Daniele Sblattero, Roberto Marzari, Fiorella Florian, Stefano Martellossi, and Alessandro Ventura

Testing for Anti-Human Transglutaminase Antibodies in Saliva Is Not Useful for Diagnosis of Celiac Disease
Clin Chem 2004 50: 216-219. [Extract] [Full Text] [PDF]  

Pauli Suominen

Evaluation of an Enzyme Immunometric Assay to Measure Serum Adiponectin Concentrations
Clin Chem 2004 50: 219-221. [Extract] [Full Text] [PDF]  

Akihiko Sekizawa, Antonio Farina, Yumi Sugito, Ryu Matsuoka, Mariko Iwasaki, Hiroshi Saito, and Takashi Okai

Proteinuria and Hypertension Are Independent Factors Affecting Fetal DNA Values: A Retrospective Analysis of Affected and Unaffected Patients
Clin Chem 2004 50: 221-224. [Extract] [Full Text] [PDF] Data Supplement  

Jennifer Rivera, Natalie Ward, Jonathan Hodgson, Ian B. Puddey, John R. Falck, and Kevin D. Croft

Measurement of 20-Hydroxyeicosatetraenoic Acid in Human Urine by Gas Chromatography–Mass Spectrometry
Clin Chem 2004 50: 224-226. [Extract] [Full Text] [PDF]  

Michael Heesen, Dagmar Kunz, Martina Wessiepe, Tom van der Poll, Aeilko H. Zwinderman, and Brunhilde Blomeke

Rapid Genotyping for Tumor Necrosis Factor- (TNF-) -863C/A Promoter Polymorphism That Determines TNF- Response
Clin Chem 2004 50: 226-228. [Extract] [Full Text] [PDF] Data Supplement  

Christoph Schmid, Michael Brändle, Cornelia Zwimpfer, Jürgen Zapf, and Peter Wiesli

Effect of Thyroxine Replacement on Creatinine, Insulin-Like Growth Factor 1, Acid-Labile Subunit, and Vascular Endothelial Growth Factor
Clin Chem 2004 50: 228-231. [Extract] [Full Text] [PDF]  

Stephen S.C. Chim, Yu-Kwan Tong, Emily C.W. Hung, Rossa W.K. Chiu, and Y.M. Dennis Lo

Genomic Sequencing of a SARS Coronavirus Isolate That Predated the Metropole Hotel Case Cluster in Hong Kong
Clin Chem 2004 50: 231-233. [Extract] [Full Text] [PDF]  

Nils G. Morgenthaler, Joachim Struck, Barbara Thomas, and Andreas Bergmann

Immunoluminometric Assay for the Midregion of Pro-Atrial Natriuretic Peptide in Human Plasma
Clin Chem 2004 50: 234-236. [Extract] [Full Text] [PDF]  

André B.P. van Kuilenburg, Henk van Lenthe, Arno van Cruchten, and Willem Kulik

Quantification of 5,6-Dihydrouracil by HPLC–Electrospray Tandem Mass Spectrometry
Clin Chem 2004 50: 236-238. [Extract] [Full Text] [PDF]  

Rima Obeid, Heike Schorr, Rudolf Eckert, and Wolfgang Herrmann

Vitamin B₁₂ Status in the Elderly as Judged by Available Biochemical Markers
Clin Chem 2004 50: 238-241. [Extract] [Full Text] [PDF] Data Supplement  

Yuzuru Takemura, Hideo Kakoi, Haku Ishida, Hideki Kure, Yuriko Tatsuguchi-Harada, Masafumi Sugawara, Yuji Inoue, Ken Ebisawa, and Morimitsu Kure

Immediate Availability of C-Reactive Protein and Leukocyte Count Data Influenced Physicians’ Decisions to Prescribe Antimicrobial Drugs for New Outpatients with Acute Infections
Clin Chem 2004 50: 241-244. [Extract] [Full Text] [PDF] Supplemental Data  

Jens Mueller, Jutta Maria Rox, Katharina Madlener, and Bernd Poetzsch

Quantitative Tissue Factor Gene Expression Analysis in Whole Blood: Development and Evaluation of a Real-Time PCR Platform
Clin Chem 2004 50: 245-247. [Extract] [Full Text] [PDF] Data Supplement  

Ilse P. van der Heiden, Marloes van der Werf, Jan Lindemans, and Ron H.N. van Schaik

Sequencing: Not Always the "Gold Standard"
Clin Chem 2004 50: 248-249. [Extract] [Full Text] [PDF]  

Claus W. Heizmann

S100B Protein in Clinical Diagnostics: Assay Specificity
Clin Chem 2004 50: 249-251. [Extract] [Full Text] [PDF]  

Siby Sebastian, Silvia G. Spitzer, Leonard E. Grosso, Jean Amos, Frederick V. Schaefer, Elaine Lyon, Daynna J. Wolff, Atieh Hajianpour, Annette K. Taylor, Alison Millson, and Timothy T. Stenzel

Multicenter Characterization and Validation of the Intron-8 Poly(T) Tract (IVS8-T) Status in 25 Coriell Cell Repository Cystic Fibrosis Reference Cell Lines for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene Mutation Assays
Clin Chem 2004 50: 251-254. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Arthur Baca, Richard J. Haber, Kirk Sujishi, Philip H. Frost, and Valerie L. Ng

Artifactual Undetectable HDL-Cholesterol with the Beckman Synchron LX and Vitros 950 Assays Temporally Associated with a Paraprotein
Clin Chem 2004 50: 255-256. [Extract] [Full Text] [PDF]  

Nicole Y.L. Lam, Timothy H. Rainer, Rossa W.K. Chiu, and Y.M. Dennis Lo

EDTA Is a Better Anticoagulant than Heparin or Citrate for Delayed Blood Processing for Plasma DNA Analysis
Clin Chem 2004 50: 256-257. [Extract] [Full Text] [PDF]  

William E. Owen and William L. Roberts

Cross-Reactivity of Three Recombinant Insulin Analogs with Five Commercial Insulin Immunoassays
Clin Chem 2004 50: 257-259. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Catherine A. Hammett-Stabler

Encyclopedia of Clinical Toxicology: A Comprehensive Guide and Reference. Irving S. Rossoff. New York, NY: The Parthenon Publishing Group. A CRC Co., 2002, 1528 pp., $299.95. ISBN 1-84214-101-5.
Clin Chem 2004 50: 260-261. [Extract] [Full Text] [PDF]  

Dale A. Chatfield and Robert L. Fitzgerald

Liquid Chromatography-Mass Spectrometry: An Introduction. Robert E. Ardrey. Huddersfield, UK: Wiley, 2003, 276 pp., $110.00, hardcover. ISBN 0-471-49799-1.
Clin Chem 2004 50: 261-262. [Extract] [Full Text] [PDF]  

Callum G. Fraser

Pediatric Reference Ranges. Steven J. Soldin, Barlo Brugnara, and Edward C. Wong, editors. Washington DC: AACC Press, 2003, 248 pp., $67.00 (AACC members $55.00). ISBN 1-890883-88-3.
Clin Chem 2004 50: 262-263. [Extract] [Full Text] [PDF]  

Erik Magid

Evidence-Based Laboratory Medicine: From Principles to Outcomes. Christopher P. Price and Robert H. Christenson. Washington, DC: AACC Press, 2003, 296 pp., $65.00 ($52.00 AACC members). ISBN 1-890883-90-5.
Clin Chem 2004 50: 262-263. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Clin Chem 2004 50: 264. [Extract] [Full Text] [PDF]  

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