Editorials:

Scott J. Cameron and Gary B. Green

Cardiac Biomarkers in Renal Disease: The Fog Is Slowly Lifting
Clin Chem 2004 50: 2233-2235. [Extract] [Full Text] [PDF]  

Omar S. Khalil

Noninvasive Photonic-Crystal Material for Sensing Glucose in Tears
Clin Chem 2004 50: 2236-2237. [Extract] [Full Text] [PDF]  

Theodore Peters, Jr

New Form of Urinary Albumin in Early Diabetes
Clin Chem 2004 50: 2238-2239. [Extract] [Full Text] [PDF]  

Reviews:

Kevin A. Francesconi and Florence Pannier

Selenium Metabolites in Urine: A Critical Overview of Past Work and Current Status
Clin Chem 2004 50: 2240-2253. Published online September 30, 2004; 10.1373/clinchem.2004.039875 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Fred S. Apple, MaryAnn M. Murakami, Lesly A. Pearce, and Charles A. Herzog

Multi-Biomarker Risk Stratification of N-Terminal Pro-B-Type Natriuretic Peptide, High-Sensitivity C-Reactive Protein, and Cardiac Troponin T and I in End-Stage Renal Disease for All-Cause Death
Clin Chem 2004 50: 2279-2285. Published online September 13, 2004; 10.1373/clinchem.2004.035741 [Abstract] [Full Text] [PDF]  

Tanya M. Osicka and Wayne D. Comper

Characterization of Immunochemically Nonreactive Urinary Albumin
Clin Chem 2004 50: 2286-2291. Published online September 23, 2004; 10.1373/clinchem.2004.039743 [Abstract] [Full Text] [PDF]  

Klaus Jung, Janett Reiche, Axel Boehme, Carsten Stephan, Stephan A. Loening, Dietmar Schnorr, Wolfgang Hoesel, and Pranav Sinha

Analysis of Subforms of Free Prostate-Specific Antigen in Serum by Two-Dimensional Gel Electrophoresis: Potential to Improve Diagnosis of Prostate Cancer
Clin Chem 2004 50: 2292-2301. Published online October 7, 2004; 10.1373/clinchem.2004.040469 [Abstract] [Full Text] [PDF] Data Supplement  

Molecular Diagnostics and Genetics:

Avraham Halperin, Arnaud Buhot, and Ekaterina B. Zhulina

Hybridization Isotherms of DNA Microarrays and the Quantification of Mutation Studies
Clin Chem 2004 50: 2254-2262. Published online September 23, 2004; 10.1373/clinchem.2004.037226 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Vladimir L. Alexeev, Sasmita Das, David N. Finegold, and Sanford A. Asher

Photonic Crystal Glucose-Sensing Material for Noninvasive Monitoring of Glucose in Tear Fluid
Clin Chem 2004 50: 2353-2360. Published online September 30, 2004; 10.1373/clinchem.2004.039701 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Christoph Bergmeier, Rüdiger Siekmeier, and Werner Gross

Distribution Spectrum of Paraoxonase Activity in HDL Fractions
Clin Chem 2004 50: 2309-2315. Published online September 30, 2004; 10.1373/clinchem.2004.034439 [Abstract] [Full Text] [PDF]  

Attila Brehm, Georg Pfeiler, Giovanni Pacini, Heinrich Vierhapper, and Michael Roden

Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Obesity
Clin Chem 2004 50: 2316-2322. Published online September 30, 2004; 10.1373/clinchem.2004.037556 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Xu Xu, Michael M. Iba, and Clifford P. Weisel

Simultaneous and Sensitive Measurement of Anabasine, Nicotine, and Nicotine Metabolites in Human Urine by Liquid Chromatography–Tandem Mass Spectrometry
Clin Chem 2004 50: 2323-2330. Published online October 7, 2004; 10.1373/clinchem.2004.038489 [Abstract] [Full Text] [PDF]  

Pernille B. Koefoed-Nielsen, Nikolaos Karamperis, and Kaj Anker Jørgensen

Validation of the Calcineurin Phosphatase Assay
Clin Chem 2004 50: 2331-2337. [Abstract] [Full Text] [PDF]  

Evidence-based Medicine and Test Utilization:

Michael Worsfold, Diane E. Powell, Teresa J.W. Jones, and Michael W.J. Davie

Assessment of Urinary Bone Markers for Monitoring Treatment of Osteoporosis
Clin Chem 2004 50: 2263-2270. Published online October 7, 2004; 10.1373/clinchem.2004.037424 [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

Jutta Maria Rox, Peter Bugert, Jens Müller, Alexander Schorr, Peter Hanfland, Katharina Madlener, Harald Klüter, and Bernd Pötzsch

Gene Expression Analysis in Platelets from a Single Donor: Evaluation of a PCR-Based Amplification Technique
Clin Chem 2004 50: 2271-2278. Published online October 7, 2004; 10.1373/clinchem.2004.035386 [Abstract] [Full Text] [PDF] Data Supplement  

Cancer Diagnostics:

Anthony W. Butch, Helen H. Chun, Shareef A. Nahas, and Richard A. Gatti

Immunoassay to Measure Ataxia-Telangiectasia Mutated Protein in Cellular Lysates
Clin Chem 2004 50: 2302-2308. Published online October 14, 2004; 10.1373/clinchem.2004.039461 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Mindy L. Rawlins and William L. Roberts

Performance Characteristics of Six Third-Generation Assays for Thyroid-Stimulating Hormone
Clin Chem 2004 50: 2338-2344. Published online October 7, 2004; 10.1373/clinchem.2004.039156 [Abstract] [Full Text] [PDF]  

Robert L. Taylor, Stefan K. Grebe, and Ravinder J. Singh

Quantitative, Highly Sensitive Liquid Chromatography–Tandem Mass Spectrometry Method for Detection of Synthetic Corticosteroids
Clin Chem 2004 50: 2345-2352. Published online October 14, 2004; 10.1373/clinchem.2004.033605 [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Xavier Bossuyt, Johan Frans, Ann Hendrickx, Godelieve Godefridis, René Westhovens, and Godelieve Mariën

Detection of Anti-SSA Antibodies by Indirect Immunofluorescence
Clin Chem 2004 50: 2361-2369. Published online October 7, 2004; 10.1373/clinchem.2004.035964 [Abstract] [Full Text] [PDF] Data Supplement  

Elke Schwertz, Franka Kahlenberg, Ulrich Sack, Thomas Richter, Martin Stern, Karsten Conrad, Klaus-Peter Zimmer, and Thomas Mothes

Serologic Assay Based on Gliadin-Related Nonapeptides as a Highly Sensitive and Specific Diagnostic Aid in Celiac Disease
Clin Chem 2004 50: 2370-2375. Published online October 7, 2004; 10.1373/clinchem.2004.036111 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Mario Berger, Silke Zschemisch, Berthold Hocher, Detlev Mönks, Torsten Slowinski, Horst Halle, Christoph Wanner, Ulrich Walter, and Tom H. Lindner

Alternative Approach for Rapid and Reliable Single-Nucleotide Polymorphism Typing with Double Restriction Mutagenesis Primer PCR
Clin Chem 2004 50: 2376-2378. [Extract] [Full Text] [PDF] Data Supplement  

Zia Fazili and Christine M. Pfeiffer

Measurement of Folates in Serum and Conventionally Prepared Whole Blood Lysates: Application of an Automated 96-Well Plate Isotope-Dilution Tandem Mass Spectrometry Method
Clin Chem 2004 50: 2378-2381. Published online September 30, 2004; 10.1373/clinchem.2004.036541 [Extract] [Full Text] [PDF] Data Supplement  

Emily C. Heider, Bret G. Davis, and Elizabeth L. Frank

Nonparametric Determination of Reference Intervals for Plasma Metanephrine and Normetanephrine
Clin Chem 2004 50: 2381-2384. [Extract] [Full Text] [PDF]  

Marina Bibikova, Joanne M. Yeakley, Eugene Chudin, Jing Chen, Eliza Wickham, Jessica Wang-Rodriguez, and Jian-Bing Fan

Gene Expression Profiles in Formalin-Fixed, Paraffin-Embedded Tissues Obtained with a Novel Assay for Microarray Analysis
Clin Chem 2004 50: 2384-2386. [Extract] [Full Text] [PDF]  

Pasquale Florio, Stefano Luisi, Matteo Bruschettini, Dariusz Grutzfeld, Anna Dobrzanska, Pierluigi Bruschettini, Felice Petraglia, and Diego Gazzolo

Cerebrospinal Fluid Activin A Measurement in Asphyxiated Full-Term Newborns Predicts Hypoxic Ischemic Encephalopathy
Clin Chem 2004 50: 2386-2389. [Extract] [Full Text] [PDF]  

Mary M. Kimberly, Samuel P. Caudill, Hubert W. Vesper, Steven F. Ethridge, Enada Archibold, Kimberly H. Porter, and Gary L. Myers

Within-Person, Among-Finger Variability of Capillary Blood Glucose Measurements
Clin Chem 2004 50: 2389-2391. [Extract] [Full Text] [PDF]  

Goce Dimeski, Tony Badrick, Robert Flatman, and Barry Ormiston

Roche IFCC Methods for Lactate Dehydrogenase Tested for Duplicate Errors with Greiner and Becton-Dickinson Lithium-Heparin and Greiner Serum Samples
Clin Chem 2004 50: 2391-2392. Published online September 23, 2004; 10.1373/clinchem.2004.039248 [Extract] [Full Text] [PDF]  

Matthew W. Hruska, Reginald F. Frye, and Taimour Y. Langaee

Pyrosequencing Method for Genotyping Cytochrome P450 CYP2C8 and CYP2C9 Enzymes
Clin Chem 2004 50: 2392-2395. [Extract] [Full Text] [PDF]  

Marion Funk, Georg Endler, Renate Freitag, Johann Wojta, Kurt Huber, Christine Mannhalter, and Raute Sunder-Plassmann

CYP2C9*2 and CYP2C9*3 Alleles Confer a Lower Risk for Myocardial Infarction
Clin Chem 2004 50: 2395-2398. [Extract] [Full Text] [PDF] Data Supplement  

Steven K. Drake, Raffick A.R. Bowen, Alan T. Remaley, and Glen L. Hortin

Potential Interferences from Blood Collection Tubes in Mass Spectrometric Analyses of Serum Polypeptides
Clin Chem 2004 50: 2398-2401. [Extract] [Full Text] [PDF]  

Elizabeth L. Sanders, Raynell J. Clark, and Jerry A. Katzmann

Cerebrospinal Fluid Leakage: Agarose Gel Electrophoresis Detection of ß₂-Transferrin and Nephelometric Quantification of ß-Trace Protein
Clin Chem 2004 50: 2401-2403. Published online September 30, 2004; 10.1373/clinchem.2004.040246 [Extract] [Full Text] [PDF]  

Xiao Yan Zhong, Yiming Wang, Suqin Chen, Labu, Pubuzhuoma, Gesangzhuogab, Ouzhuwangmu, Xiaoying Pan, Ninghu Zhu, Cornelia Hahn, Berthold Huppertz, Wolfgang Holzgreve, and Sinuhe Hahn

Circulating Fetal DNA in Maternal Plasma Is Increased in Pregnancies at High Altitude and Is Further Enhanced by Preeclampsia
Clin Chem 2004 50: 2403-2405. [Extract] [Full Text] [PDF]  

Doris M. Haverstick, Grant C. Bullock, and David E. Bruns

Genotyping of Hepatitis C Virus by Melting Curve Analysis: Analytical Characteristics and Performance
Clin Chem 2004 50: 2405-2407. [Extract] [Full Text] [PDF]  

Sten Gershagen and Sabina Janciauskiene

ELISA for Specific Detection of PiZ-Related ₁-Antitrypsin Deficiency
Clin Chem 2004 50: 2407-2410. [Extract] [Full Text] [PDF]  

Masato Maekawa, Terumi Taniguchi, Jinko Ishikawa, Shigeru Toyoda, and Noriko Takahata

Problem with Detection of an Insertion-Type Mutation in the BCHE Gene in a Patient with Butyrylcholinesterase Deficiency
Clin Chem 2004 50: 2410-2411. [Extract] [Full Text] [PDF] Data Supplement  

Kazuyuki Matsuda, Kazuyoshi Yamauchi, Minoru Tozuka, Takefumi Suzuki, Mitsutoshi Sugano, Eiko Hidaka, Kenji Sano, and Tsutomu Katsuyama

Monitoring of Hematopoietic Chimerism by Short Tandem Repeats, and the Effect of CD Selection on Its Sensitivity
Clin Chem 2004 50: 2411-2414. [Extract] [Full Text] [PDF] Data Supplement  

Clinical Chemistry: A Journal Timeline:

Robert Rej

Clinical Chemistry through Clinical Chemistry: A Journal Timeline
Clin Chem 2004 50: 2415-2458. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Núria Monge-Azemar and Xavier Fuentes-Arderiu

More on Premetrologic Variation
Clin Chem 2004 50: 2459-2460. [Extract] [Full Text] [PDF]  

Wendy Jones, Jeff Scott, Sam Leary, Fay Stratton, Susan Smith, Richard Jones, Andrew Day, Andrew Ness, and ALSPAC Study Team

Stability of Whole Blood at –70 °C for Measurement of Hemoglobin A_1c in Healthy Individuals
Clin Chem 2004 50: 2460-2461. [Extract] [Full Text] [PDF]  

Antonette C.P. Allen, Francis A. Chiafari, Rita Kandel, and Thomas Rohan

Additional Data for Oligonucleotide Arrays of the p53 Gene in DNA from Formalin-Fixed, Paraffin-Embedded Tissue • Drs. Kandel and Rohan respond:
Clin Chem 2004 50: 2461-2462. Published online September 30, 2004; 10.1373/clinchem.2004.038158 [Extract] [Full Text] [PDF]  

Cathal McCarthy, Fergus Ryan, and Joseph Vaughan

Increased Frequency of the MTHFR A1298C Mutation in an Irish Population
Clin Chem 2004 50: 2462-2463. [Extract] [Full Text] [PDF]  

John Shepherd and Brian Baldwin

Interference in Measurement of Potassium Caused by Bacterial Contamination of an Analyzer
Clin Chem 2004 50: 2463-2464. [Extract] [Full Text] [PDF]  

Aldo Clerico, Michele Emdin, Jens Peter Goetze, and Jens F. Rehfeld

Endocrine Paradox in Heart Failure: Resistance to Biological Effects of Cardiac Natriuretic Hormones • Drs. Goetze and Rehfeld respond:
Clin Chem 2004 50: 2465-2468. [Extract] [Full Text] [PDF]  

Jaap Bakker, Inge Gies, Barbara Slavenburg, Otto Bekers, Tammo Delhaas, and Marja van Dieijen-Visser

Reference Values for N-Terminal Pro-B-Type Natriuretic Peptide in Umbilical Cord Blood
Clin Chem 2004 50: 2465. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

David W. Ball

Modern Spectroscopy, 4th ed. J. Michael Hollas. New York: John Wiley & Sons, Inc., 2004, 428 pp., $45.00, paperback. ISBN 0-470-84416-7.
Clin Chem 2004 50: 2469-2470. [Extract] [Full Text] [PDF]  

Michele Caggana

Principles of Molecular Pathology. Anthony A. Killeen. Totowa, NJ: Humana Press, 2003, 344 pp., $99.50, hardcover. ISBN 1-58829-085-9.
Clin Chem 2004 50: 2469. [Extract] [Full Text] [PDF]  

Piotr Grodzinski

Microsystem Engineering of Lab-on-a-Chip Devices. Oliver Geschke, Henning Klank, and Pieter Telleman, editors. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KgaA, 2004, 270 pp., $99.95, hardcover. ISBN 3-527-30733-8.
Clin Chem 2004 50: 2470-2471. [Extract] [Full Text] [PDF]  

Luis M. Rocha and Andreas Rechtsteiner

Bioinformatics for Geneticists. Michael R. Barnes and Ian C. Gray, editors. Chichester, West Sussex, United Kingdom: John Wiley & Sons Ltd., 2003, 422 pp., $65.00, softcover. ISBN 0-470-84394-2.
Clin Chem 2004 50: 2471-2472. [Extract] [Full Text] [PDF]  

Call for Nominations:

Call for Nominations
Clin Chem 2004 50: 2472. [Extract] [Full Text] [PDF]  

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