Editorials:

Patrick M.M. Bossuyt

The Quality of Reporting in Diagnostic Test Research: Getting Better, Still Not Optimal
Clin Chem 2004 50: 465-466. [Extract] [Full Text] [PDF]  

Deborah Marsden and Cecilia A. Larson

Emerging Role for Tandem Mass Spectrometry in Detecting Congenital Adrenal Hyperplasia
Clin Chem 2004 50: 467-468. [Extract] [Full Text] [PDF]  

John M. Hamlyn

Biosynthesis of Endogenous Cardiac Glycosides by Mammalian Adrenocortical Cells: Three Steps Forward
Clin Chem 2004 50: 469-470. [Extract] [Full Text] [PDF]  

Michael Laposata

Patient-specific Narrative Interpretations of Complex Clinical Laboratory Evaluations: Who Is Competent to Provide Them?
Clin Chem 2004 50: 471-472. [Extract] [Full Text] [PDF]  

Opinion:

Karel G.M. Moons, Cornee J. Biesheuvel, and Diederick E. Grobbee

Test Research versus Diagnostic Research
Clin Chem 2004 50: 473-476. [Extract] [Full Text] [PDF]  

Current Issues in Laboratory Medicine:

Vinod K. Bhutani and Lois H. Johnson

Urgent Clinical Need for Accurate and Precise Bilirubin Measurements in the United States to Prevent Kernicterus
Clin Chem 2004 50: 477-480. Published online January 15, 2004; 10.1373/clinchem.2003.024489 [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Chiung-Yu Chen, Shu-Chu Shiesh, and Sheu-Jen Wu

Rapid Detection of K-ras Mutations in Bile by Peptide Nucleic Acid-mediated PCR Clamping and Melting Curve Analysis: Comparison with Restriction Fragment Length Polymorphism Analysis
Clin Chem 2004 50: 481-489. Published online January 12, 2004; 10.1373/clinchem.2003.024505 [Abstract] [Full Text] [PDF] Data Supplement  

Christian Hafner, Gerd Schmitz, Stefanie Meyer, Frauke Bataille, Peter Hau, Thomas Langmann, Wolfgang Dietmaier, Michael Landthaler, and Thomas Vogt

Differential Gene Expression of Eph Receptors and Ephrins in Benign Human Tissues and Cancers
Clin Chem 2004 50: 490-499. Published online January 15, 2004; 10.1373/clinchem.2003.026849 [Abstract] [Full Text] [PDF] Data Supplement  

Melissa Cooper, Shu-Qiu Li, Tajinder Bhardwaj, Thomas Rohan, and Rita A. Kandel

Evaluation of Oligonucleotide Arrays for Sequencing of the p53 Gene in DNA from Formalin-Fixed, Paraffin-Embedded Breast Cancer Specimens
Clin Chem 2004 50: 500-508. Published online January 15, 2004; 10.1373/clinchem.2003.025221 [Abstract] [Full Text] [PDF] Data Supplement  

Anders Ståhlberg, Joakim Håkansson, Xiaojie Xian, Henrik Semb, and Mikael Kubista

Properties of the Reverse Transcription Reaction in mRNA Quantification
Clin Chem 2004 50: 509-515. Published online January 15, 2004; 10.1373/clinchem.2003.026161 [Abstract] [Full Text] [PDF] Data Supplement  

Kirby L. Johnson, Kimberly A. Dukes, John Vidaver, Erik S. LeShane, Idania Ramirez, William D. Weber, Farideh Z. Bischoff, Sinuhe Hahn, Arun Sharma, Dianne X. Dang, Lisa M. Hire, Diana W. Bianchi, Joe Leigh Simpson, Wolfgang Holzgreve, Sherman Elias, and Katherine W. Klinger

Interlaboratory Comparison of Fetal Male DNA Detection from Common Maternal Plasma Samples by Real-Time PCR
Clin Chem 2004 50: 516-521. Published online January 12, 2004; 10.1373/clinchem.2003.024380 [Abstract] [Full Text] [PDF]  

Kent E. Kruckeberg and Stephen N. Thibodeau

Pyrosequencing Technology as a Method for the Diagnosis of Multiple Endocrine Neoplasia Type 2
Clin Chem 2004 50: 522-529. Published online January 12, 2004; 10.1373/clinchem.2003.027128 [Abstract] [Full Text] [PDF]  

Evidence-based Laboratory Medicine and Test Utilization:

Blanca Lumbreras-Lacarra, José Manuel Ramos-Rincón, and Ildefonso Hernández-Aguado

Methodology in Diagnostic Laboratory Test Research in Clinical Chemistry and Clinical Chemistry and Laboratory Medicine
Clin Chem 2004 50: 530-536. Published online January 12, 2004; 10.1373/clinchem.2003.019786 [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

Leon Poller, Michelle Keown, Nikhil Chauhan, Anton M.H.P. van den Besselaar, Armando Tripodi, Caroline Shiach, and Jorgen Jespersen

European Concerted Action on Anticoagulation. Quality Assessment of the CoaguChek Mini and TAS PT-NC Point-of-Care Whole-Blood Prothrombin Time Monitors
Clin Chem 2004 50: 537-544. Published online January 6, 2004; 10.1373/clinchem.2003.019653 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Harald Tammen, Thomas Möhring, Markus Kellmann, Andreas Pich, Hans H. Kreipe, and Rüdiger Hess

Mass Spectrometric Phenotyping of Val34Leu Polymorphism of Blood Coagulation Factor XIII by Differential Peptide Display
Clin Chem 2004 50: 545-551. Published online January 15, 2004; 10.1373/clinchem.2003.028209 [Abstract] [Full Text] [PDF] Data Supplement  

Stefan Herget-Rosenthal, Dennis Poppen, Johannes Hüsing, Günter Marggraf, Frank Pietruck, Heinz-Günther Jakob, Thomas Philipp, and Andreas Kribben

Prognostic Value of Tubular Proteinuria and Enzymuria in Nonoliguric Acute Tubular Necrosis
Clin Chem 2004 50: 552-558. Published online January 6, 2004; 10.1373/clinchem.2003.027763 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Michael J. Duffy, Catherine Duggan, Rachel Keane, Arnold D.K. Hill, Enda McDermott, John Crown, and Niall O’Higgins

High Preoperative CA 15-3 Concentrations Predict Adverse Outcome in Node-Negative and Node-Positive Breast Cancer: Study of 600 Patients with Histologically Confirmed Breast Cancer
Clin Chem 2004 50: 559-563. Published online January 15, 2004; 10.1373/clinchem.2003.025288 [Abstract] [Full Text] [PDF]  

Talal El-Hefnawy, Siva Raja, Lori Kelly, William L. Bigbee, John M. Kirkwood, James D. Luketich, and Tony E. Godfrey

Characterization of Amplifiable, Circulating RNA in Plasma and Its Potential as a Tool for Cancer Diagnostics
Clin Chem 2004 50: 564-573. Published online January 12, 2004; 10.1373/clinchem.2003.028506 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Earl S. Ford, Wayne H. Giles, Ali H. Mokdad, and Gary L. Myers

Distribution and Correlates of C-Reactive Protein Concentrations among Adult US Women
Clin Chem 2004 50: 574-581. Published online January 6, 2004; 10.1373/clinchem.2003.027359 [Abstract] [Full Text] [PDF]  

Duk-Hee Lee, Myron D. Gross, and David R. Jacobs, Jr

Association of Serum Carotenoids and Tocopherols with -Glutamyltransferase: The Cardiovascular Risk Development in Young Adults (CARDIA) Study
Clin Chem 2004 50: 582-588. Published online January 15, 2004; 10.1373/clinchem.2003.028852 [Abstract] [Full Text] [PDF]  

Hiroaki Hattori, Takeshi Kujiraoka, Tohru Egashira, Eiji Saito, Takayuki Fujioka, Sadao Takahashi, Mayumi Ito, Jackie A. Cooper, Irina P. Stepanova, M. Nazeem Nanjee, and Norman E. Miller

Association of Coronary Heart Disease with Pre-ß-HDL Concentrations in Japanese Men
Clin Chem 2004 50: 589-595. Published online January 15, 2004; 10.1373/clinchem.2003.029207 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Jana Thorspecken, Gisela Skopp, and Lucia Pötsch

In Vitro Contamination of Hair by Marijuana Smoke
Clin Chem 2004 50: 596-602. Published online January 15, 2004; 10.1373/clinchem.2003.026120 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Susan A. Lagerstedt, Dennis J. O’Kane, and Ravinder J. Singh

Measurement of Plasma Free Metanephrine and Normetanephrine by Liquid Chromatography–Tandem Mass Spectrometry for Diagnosis of Pheochromocytoma
Clin Chem 2004 50: 603-611. Published online January 15, 2004; 10.1373/clinchem.2003.024703 [Abstract] [Full Text] [PDF]  

Hassan M.A.M. Qazzaz, Zhimin Cao, Duane D. Bolanowski, Barbara J. Clark, and Roland Valdes, Jr

De Novo Biosynthesis and Radiolabeling of Mammalian Digitalis-Like Factors
Clin Chem 2004 50: 612-620. [Abstract] [Full Text] [PDF]  

Jean M. Lacey, Carla Z. Minutti, Mark J. Magera, Angela L. Tauscher, Bruno Casetta, Mark McCann, James Lymp, Si Houn Hahn, Piero Rinaldo, and Dietrich Matern

Improved Specificity of Newborn Screening for Congenital Adrenal Hyperplasia by Second-Tier Steroid Profiling Using Tandem Mass Spectrometry
Clin Chem 2004 50: 621-625. Published online December 4, 2003; 10.1373/clinchem.2003.027193 [Abstract] [Full Text] [PDF]  

Vincenzo Carnevale, Simona Dionisi, Italo Nofroni, Elisabetta Romagnoli, Federica Paglia, Simona De Geronimo, Jessica Pepe, Giovanni Clemente, Gianfranco Tonnarini, and Salvatore Minisola

Potential Clinical Utility of a New IRMA for Parathyroid Hormone in Postmenopausal Patients with Primary Hyperparathyroidism
Clin Chem 2004 50: 626-631. Published online January 12, 2004; 10.1373/clinchem.2003.026328 [Abstract] [Full Text] [PDF]  

Laboratory Management:

Ee Mun Lim, Ken A. Sikaris, Janice Gill, John Calleja, Peter E. Hickman, John Beilby, and Samuel D. Vasikaran

Quality Assessment of Interpretative Commenting in Clinical Chemistry
Clin Chem 2004 50: 632-637. [Abstract] [Full Text] [PDF] Data Supplement  

Technical Briefs:

Yijun Li, Knut Brockmann, Frantisek Turecek, C. Ronald Scott, and Michael H. Gelb

Tandem Mass Spectrometry for the Direct Assay of Enzymes in Dried Blood Spots: Application to Newborn Screening for Krabbe Disease
Clin Chem 2004 50: 638-640. [Extract] [Full Text] [PDF] Data Supplement  

Carsten Skarke, Anja Kirchhof, Gerd Geisslinger, and Jörn Lötsch

Comprehensive Mu-Opioid-Receptor Genotyping by Pyrosequencing
Clin Chem 2004 50: 640-644. [Extract] [Full Text] [PDF] Data Supplement  

Lars Palmqvist, Philipp Goerttler, Carina Wasslavik, Peter Johansson, Björn Andreasson, Soodabeh Safai-Kutti, Jack Kutti, Heike L. Pahl, and Anne Ricksten

Comparison of Methods for Polycythemia Rubra Vera-1 mRNA Quantification in Whole-Blood Leukocytes and Purified Granulocytes
Clin Chem 2004 50: 644-647. [Extract] [Full Text] [PDF] Data Supplement  

Jae-Young Um, Hwan-Suck Chung, Mi-Yeon Song, Hyun-Dae Shin, and Hyung-Min Kim

Association of Interleukin-1ß Gene Polymorphism with Body Mass Index in Women
Clin Chem 2004 50: 647-650. [Extract] [Full Text] [PDF] Data Suypplement  

Christoph Schmid, Peter Wiesli, René Bernays, Konrad Bloch, Jürgen Zapf, Cornelia Zwimpfer, Claudia Ghirlanda, and Michael Brändle

Decrease in sE-Selectin after Pituitary Surgery in Patients with Acromegaly
Clin Chem 2004 50: 650-652. [Extract] [Full Text] [PDF]  

Thomas W. McDade, James Burhop, and James Dohnal

High-Sensitivity Enzyme Immunoassay for C-Reactive Protein in Dried Blood Spots
Clin Chem 2004 50: 652-654. [Extract] [Full Text] [PDF]  

Eve B. Schwartz and Douglas A. Granger

Transferrin Enzyme Immunoassay for Quantitative Monitoring of Blood Contamination in Saliva
Clin Chem 2004 50: 654-656. [Extract] [Full Text] [PDF]  

Jan Philippé, Erik De Logi, and Gaston Baele

Comparison of Five Different Citrated Tubes and Their in Vitro Effects on Platelet Activation
Clin Chem 2004 50: 656-658. [Extract] [Full Text] [PDF]  

Masayoshi Takahashi, Jun Okada, Keiko Ito, Michie Hashimoto, Koji Hashimoto, Yuri Yoshida, Yasuhiro Furuichi, Yasuhiko Ohta, Shunji Mishiro, and Nobuhiro Gemma

Electrochemical DNA Array for Simultaneous Genotyping of Single-Nucleotide Polymorphisms Associated with the Therapeutic Effect of Interferon
Clin Chem 2004 50: 658-661. [Extract] [Full Text] [PDF]  

Claudia Schnabel, Ercole Di Martino, Joachim M. Gilsbach, Dieter Riediger, Axel M. Gressner, and Dagmar Kunz

Comparison of ß₂-Transferrin and ß-Trace Protein for Detection of Cerebrospinal Fluid in Nasal and Ear Fluids
Clin Chem 2004 50: 661-663. [Extract] [Full Text] [PDF] Data Supplement  

Ellen F. Foxman and Petr Jarolim

Use of the Fetal Fibronectin Test in Decisions to Admit to Hospital for Preterm Labor
Clin Chem 2004 50: 663-665. [Extract] [Full Text] [PDF]  

Rama Sethuraman, Tat Leang Lee, and Shinro Tachibana

Simple Quantitative HPLC Method for Measuring Physiologic Amino Acids in Cerebrospinal Fluid without Pretreatment
Clin Chem 2004 50: 665-669. [Extract] [Full Text] [PDF] Data Supplement  

Myra D. Smith, Janis E. Davis-Street, Dick S. Calkins, Jeannie L. Nillen, and Scott M. Smith

Stability of i-Stat ^EC6+ Cartridges: Effect of Storage Temperature on Shelf Life
Clin Chem 2004 50: 669-673. [Extract] [Full Text] [PDF] Data Supplement  

Paul Froom, Rachel Etzion, and Mira Barak

What Is an Abnormal Test Strip Urinary Erythrocyte Concentration?
Clin Chem 2004 50: 673-675. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Mauro Panteghini

The Interfering Component in Cardiac Troponin I Immunoassays: Need for Further Experimental Evidence
Clin Chem 2004 50: 676-677. [Extract] [Full Text] [PDF]  

Nasir A. Al-Allawi, Jaladet M.S. Jubrael, and Ferial A. Hilmi

Factor V Leiden in Blood Donors in Baghdad (Iraq)
Clin Chem 2004 50: 677-678. [Extract] [Full Text] [PDF]  

Peter A. Torjesen, Liv Sandnes, and Philippe Boudou

Serum Testosterone in Women as Measured by an Automated Immunoassay and a RIA • Dr. Boudou responds for the authors of the article cited above:
Clin Chem 2004 50: 678-679. [Extract] [Full Text] [PDF]  

Robbert J.P. Rijnders, Godelieve C.M.L. Christiaens, Aicha Ait Soussan, C. Ellen van der Schoot, Pietro Invernizzi, Giuseppe Simoni, and Mauro Podda

Cell-Free Fetal DNA Is Not Present in Plasma of Nonpregnant Mothers • Authors of the article cited above respond:
Clin Chem 2004 50: 679-681. [Extract] [Full Text] [PDF]  

Dimitrios-Petrou Bogdanos, Ilaria Bianchi, Yun Ma, Ragai R. Mitry, Giorgina Mieli-Vergani, Diego Vergani, Eric Ballot, Arnaud Bruneel, and Catherine Johanet

Targets of Antibodies to Soluble Liver Antigen in Patients with Autoimmune Hepatitis • Drs. Ballot, Bruneel, and Johanet respond:
Clin Chem 2004 50: 682-684. [Extract] [Full Text] [PDF]  

Corrections:

Fifty Years of Clinical Chemistry
Clin Chem 2004 50: 684. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Helge Erik Solberg

Clinical Diagnostic Technology. The Total Testing Process. Vol. 1: The Preanalytical Phase. K.M. Ward-Cook, C.A. Lehmann, L.E. Schoeff, and R.H. Williams, editors. Washington, DC: AACC Press, 2003, $49.00 ($39.00 AACC members). ISBN 1-890883-89-1.
Clin Chem 2004 50: 685. [Extract] [Full Text] [PDF]  

Larry L. Needham

Biological Monitoring: Prospects in Occupational and Environmental Medicine. Jürgen Angerer and Tobias Weiss, editors. Weinheim, Federal Republic of Germany: Wiley-VCH Verlag GmbH Co., 2002, 212 pp., $85.00, softcover. ISBN 3-527-27795-1.
Clin Chem 2004 50: 685-686. [Extract] [Full Text] [PDF]  

John Bernard Henry

The Short Road to Great Presentations. Peter Reimold and Cheryl Reimold. Piscataway, NJ: Wiley-IEEE Press, 2003, 342 pp., $39.95. ISBN 0-47128-136-0.
Clin Chem 2004 50: 686. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Clin Chem 2004 50: 687-688. [Extract] [Full Text] [PDF]  

Patricia M. Jones

Clin Chem 2004 50: 687-688. [Extract] [Full Text] [PDF]  

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