Editorials:

Eleftherios P. Diamandis

How Are We Going to Discover New Cancer Biomarkers? A Proteomic Approach for Bladder Cancer
Clin Chem 2004 50: 793-795. [Extract] [Full Text] [PDF]  

Louis Rosenfeld

A Century of Growth: A Century of Progress
Clin Chem 2004 50: 796-797. [Extract] [Full Text] [PDF]  

Ulf-Håkan Stenman

Standardization of Assays for Human Chorionic Gonadotropin
Clin Chem 2004 50: 798-800. [Extract] [Full Text] [PDF]  

Frederick S. Nolte

Novel Internal Controls For Real-Time PCR Assays
Clin Chem 2004 50: 801-802. [Extract] [Full Text] [PDF]  

Sverre Sandberg and George H. Elder

Diagnosing Acute Porphyrias
Clin Chem 2004 50: 803-805. [Extract] [Full Text] [PDF]  

Special Reports:

Wytze P. Oosterhuis, David E. Bruns, Joseph Watine, Sverre Sandberg, and Andrea R. Horvath

Evidence-Based Guidelines in Laboratory Medicine: Principles and Methods
Clin Chem 2004 50: 806-818. [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Siegfried Burggraf and Bernhard Olgemöller

Simple Technique for Internal Control of Real-Time Amplification Assays
Clin Chem 2004 50: 819-825. Published online March 9, 2004; 10.1373/clinchem.2003.027961 [Abstract] [Full Text] [PDF]  

S. Mark O’Hara, Jose G. Moreno, Daniel R. Zweitzig, Steve Gross, Leonard G. Gomella, and Leon W.M.M. Terstappen

Multigene Reverse Transcription-PCR Profiling of Circulating Tumor Cells in Hormone-Refractory Prostate Cancer
Clin Chem 2004 50: 826-835. Published online February 26, 2004; 10.1373/clinchem.2003.028563 [Abstract] [Full Text] [PDF] Data Supplement  

Charles M. Strom, David D. Clark, Feras M. Hantash, Larry Rea, Ben Anderson, Diana Maul, Donghui Huang, Donald Traul, Christina Chen Tubman, Renee Garcia, P. Patrick Hess, Hong Wang, Beryl Crossley, Evelyn Woodruff, Rebecca Chen, Myra Killeen, Weimin Sun, Jonathan Beer, Heather Avens, Barry Polisky, and Robert D. Jenison

Direct Visualization of Cystic Fibrosis Transmembrane Regulator Mutations in the Clinical Laboratory Setting
Clin Chem 2004 50: 836-845. Published online March 9, 2004; 10.1373/clinchem.2003.026088 [Abstract] [Full Text] [PDF] Data Supplement  

Kyeong Man Hong, Hazim Najjar, Mary Hawley, and Richard D. Press

Quantitative Real-Time PCR with Automated Sample Preparation for Diagnosis and Monitoring of Cytomegalovirus Infection in Bone Marrow Transplant Patients
Clin Chem 2004 50: 846-856. Published online March 9, 2004; 10.1373/clinchem.2003.026484 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Susumu Kageyama, Takahiro Isono, Hideaki Iwaki, Yoshihiko Wakabayashi, Yusaku Okada, Keiichi Kontani, Koji Yoshimura, Akito Terai, Yoichi Arai, and Tatsuhiro Yoshiki

Identification by Proteomic Analysis of Calreticulin as a Marker for Bladder Cancer and Evaluation of the Diagnostic Accuracy of Its Detection in Urine
Clin Chem 2004 50: 857-866. Published online February 5, 2004; 10.1373/clinchem.2003.027425 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Alan H.B. Wu, Milton Packer, Andrew Smith, Rachel Bijou, Daniel Fink, Johannes Mair, Lars Wallentin, Nina Johnston, Carolyn S. Feldcamp, Doris M. Haverstick, Charaf E. Ahnadi, Andrew Grant, Normand Despres, Barry Bluestein, and Farooq Ghani

Analytical and Clinical Evaluation of the Bayer ADVIA Centaur Automated B-Type Natriuretic Peptide Assay in Patients with Heart Failure: A Multisite Study
Clin Chem 2004 50: 867-873. Published online March 9, 2004; 10.1373/clinchem.2003.026138 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Laurence A. Cole, Jaime M. Sutton, Trefor N. Higgins, and George S. Cembrowski

Between-Method Variation in Human Chorionic Gonadotropin Test Results
Clin Chem 2004 50: 874-882. Published online March 11, 2004; 10.1373/clinchem.2003.026989 [Abstract] [Full Text] [PDF]  

Sari L. Alatalo, Kaisa K. Ivaska, Steven G. Waguespack, Michael J. Econs, H. Kalervo Väänänen, and Jussi M. Halleen

Osteoclast-Derived Serum Tartrate-Resistant Acid Phosphatase 5b in Albers-Schönberg Disease (Type II Autosomal Dominant Osteopetrosis)
Clin Chem 2004 50: 883-890. Published online March 11, 2004; 10.1373/clinchem.2003.029355 [Abstract] [Full Text] [PDF]  

Laboratory Management:

Ari Lahti, Per Hyltoft Petersen, James C. Boyd, Pål Rustad, Petter Laake, and Helge Erik Solberg

Partitioning of Nongaussian-Distributed Biochemical Reference Data into Subgroups
Clin Chem 2004 50: 891-900. Published online March 9, 2004; 10.1373/clinchem.2003.027953 [Abstract] [Full Text] [PDF] Data Supplement  

Martin Koduah, Terence C. Iles, and Barry J. Nix

Centile Charts I: New Method of Assessment for Univariate Reference Intervals
Clin Chem 2004 50: 901-906. Published online March 11, 2004; 10.1373/clinchem.2003.023762 [Abstract] [Full Text] [PDF] Data Supplement  

Jenny K. Griffiths, Terence C. Iles, Martin Koduah, and Arthur B.J. Nix

Centile Charts II: Alternative Nonparametric Approach for Establishing Time-Specific Reference Centiles and Assessment of the Sample Size Required
Clin Chem 2004 50: 907-914. Published online March 11, 2004; 10.1373/clinchem.2003.023770 [Abstract] [Full Text] [PDF] Data Supplement  

General Clinical Chemistry:

Richard J. Hift, Brandon P. Davidson, Cornelis van der Hooft, Doreen M. Meissner, and Peter N. Meissner

Plasma Fluorescence Scanning and Fecal Porphyrin Analysis for the Diagnosis of Variegate Porphyria: Precise Determination of Sensitivity and Specificity with Detection of Protoporphyrinogen Oxidase Mutations as a Reference Standard
Clin Chem 2004 50: 915-923. Published online February 19, 2004; 10.1373/clinchem.2003.025213 [Abstract] [Full Text] [PDF]  

Rebecca C. Miller, Eleanor Brindle, Darryl J. Holman, Jane Shofer, Nancy A. Klein, Michael R. Soules, and Kathleen A. O’Connor

Comparison of Specific Gravity and Creatinine for Normalizing Urinary Reproductive Hormone Concentrations
Clin Chem 2004 50: 924-932. Published online March 11, 2004; 10.1373/clinchem.2004.032292 [Abstract] [Full Text] [PDF]  

Technical Briefs:

David F. Keren, Ronald Gulbranson, and Stephen J. Ebrom

False-Negative Urine Protein Electrophoresis by Semiautomated Gel Electrophoresis
Clin Chem 2004 50: 933-934. [Extract] [Full Text] [PDF]  

Thomas Marshall and Katherine M. Williams

Extent of Aminoglycoside Interference in the Pyrogallol Red-Molybdate Protein Assay Depends on the Concentration of Sodium Oxalate in the Dye Reagent
Clin Chem 2004 50: 934-935. [Extract] [Full Text] [PDF]  

Anders Helander and Olof Beck

Mass Spectrometric Identification of Ethyl Sulfate as an Ethanol Metabolite in Humans
Clin Chem 2004 50: 936-937. [Extract] [Full Text] [PDF]  

Henk J. Huijgen, Frans P.W. Tegelaers, Christian H.H. Schoenmakers, Claudia J. Pronk-Admiraal, and Sjaak Ekema

Multicenter Analytical Evaluation of an Enzymatic Method for the Measurement of Plasma Homocysteine and Comparison with HPLC and Immunochemistry
Clin Chem 2004 50: 937-940. [Extract] [Full Text] [PDF]  

Diego Gazzolo, Dariusz Grutzfeld, Fabrizio Michetti, Amelia Toesca, Mario Lituania, Matteo Bruschettini, Anna Dobrzanska, and Pierluigi Bruschettini

Increased S100B in Cerebrospinal Fluid of Infants with Bacterial Meningitis: Relationship to Brain Damage and Routine Cerebrospinal Fluid Findings
Clin Chem 2004 50: 941-944. [Extract] [Full Text] [PDF]  

Martin Hersberger, Charly Nusbaumer, André Scholer, Verena Knöpfli, and Arnold von Eckardstein

Influence of Practicable Virus Inactivation Procedures on Tests for Frequently Measured Analytes in Plasma
Clin Chem 2004 50: 944-946. [Extract] [Full Text] [PDF]  

Rémy Sapin, Arnaud Agin, and Françoise Gasser

Misleading High Thyrotropin Results Obtained with a Two-Site Immunometric Assay Involving a Chimeric Antibody
Clin Chem 2004 50: 946-948. [Extract] [Full Text] [PDF]  

Carl A. Hubel, Lisa M. Bodnar, Ariel Many, Gail Harger, Roberta B. Ness, and James M. Roberts

Nonglycosylated Ferritin Predominates in the Circulation of Women with Preeclampsia but Not Intrauterine Growth Restriction
Clin Chem 2004 50: 948-951. [Extract] [Full Text] [PDF] Data Supplement  

Chi Chiu Wang, Ching Yan Chu, Kai On Chu, Kwong Wai Choy, Kim Sun Khaw, Michael Scott Rogers, and Chi Pui Pang

Trolox-Equivalent Antioxidant Capacity Assay Versus Oxygen Radical Absorbance Capacity Assay in Plasma
Clin Chem 2004 50: 952-954. [Extract] [Full Text] [PDF]  

Anders Helander, Jonas Bergström, and Hudson H. Freeze

Testing for Congenital Disorders of Glycosylation by HPLC Measurement of Serum Transferrin Glycoforms
Clin Chem 2004 50: 954-958. [Extract] [Full Text] [PDF]  

D. Robert Dufour

Lot-to-Lot Variation in Anti-Hepatitis C Signal-to-Cutoff Ratio
Clin Chem 2004 50: 958-960. [Extract] [Full Text] [PDF] Data Supplement  

History:

Noel G. Coley

Medical Chemists and the Origins of Clinical Chemistry in Britain (circa 1750–1850)
Clin Chem 2004 50: 961-972. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Ingrid P. Senden, Christianne J.M. de Groot, Eric A.P. Steegers, Rogier M. Bertina, and Dorine W. Swinkels

Preeclampsia and the C282Y Mutation in the Hemochromatosis (HFE) Gene
Clin Chem 2004 50: 973-974. [Extract] [Full Text] [PDF]  

Volkher Scharnhorst, Jan Valkenburg, Cor Vosters, and Huib Vader

Influence of Preanalytical Factors on the Immulite Intact Parathyroid Hormone Assay
Clin Chem 2004 50: 974-975. [Extract] [Full Text] [PDF]  

Suzanne Egyházi, Judith Bjöhle, Lambert Skoog, Fei Huang, Anna-Lena Borg, Marianne Frostvik Stolt, Torsten Hägerström, Ulrik Ringborg, and Jonas Bergh

Proteinase K Added to the Extraction Procedure Markedly Increases RNA Yield from Primary Breast Tumors for Use in Microarray Studies
Clin Chem 2004 50: 975-976. [Extract] [Full Text] [PDF]  

Goce Dimeski

Effects of Hemolysis on the Roche Ammonia Method for Hitachi Analyzers
Clin Chem 2004 50: 976-977. [Extract] [Full Text] [PDF]  

Rudolf M. Lequin

Guide to the Expression of Uncertainty of Measurement: Point/Counterpoint
Clin Chem 2004 50: 977-978. [Extract] [Full Text] [PDF]  

Toshiyuki Yamada

Genetic Effects on Serum Concentrations of Serum Amyloid A Protein
Clin Chem 2004 50: 978-979. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Ronald C. McGlennen

Microchips: The Illustrated Hitchhiker’s Guide to Analytical Microchips. Larry J. Kricka. Washington, DC: AACC Press, 2002, 104 pp., $25.00 ($20.00 AACC members), softcover. ISBN 1-890883-75-1.
Clin Chem 2004 50: 980. [Extract] [Full Text] [PDF]  

Curtis A. Parvin

An Introduction to Multivariate Statistical Analysis, 3rd ed. T.W. Anderson. Hoboken, NJ: John Wiley & Sons, 2003, 742 pp., $99.95, hardcover. ISBN 0-471-36091-0.
Clin Chem 2004 50: 981-982. [Extract] [Full Text] [PDF]  

Maurizio Ferrari

Introduction to Nanotechnology. Charles P. Poole, Jr., and Frank J. Owens. Hoboken, NJ: John Wiley & Sons, 2003, 400 pp., $79.95, hardcover. ISBN 0-471-07935-9.
Clin Chem 2004 50: 981. [Extract] [Full Text] [PDF]  

Corrections:

Correction
Clin Chem 2004 50: 982. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

The Monica Dogaru Story
Clin Chem 2004 50: 983-984. [Extract] [Full Text] [PDF]  

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