Editorials:

Thomas R. Gingeras

RNA Reference Materials for Gene Expression Studies: Point: Difficult First Steps
Clin Chem 2004 50: 1289-1290. [Extract] [Full Text] [PDF]  

Loren J. Joseph

RNA Reference Materials for Gene Expression Studies: Counterpoint: RNA Metrology: Forecast Calls for Partial Clearing
Clin Chem 2004 50: 1290-1292. [Extract] [Full Text] [PDF]  

Per Magne Ueland and Stein Emil Vollset

Homocysteine and Folate in Pregnancy
Clin Chem 2004 50: 1293-1295. [Extract] [Full Text] [PDF]  

W. Edward Highsmith, Jr

SNPs for Sale. Cheap!
Clin Chem 2004 50: 1296-1298. [Extract] [Full Text] [PDF]  

Nezam H. Afdhal

Biopsy or Biomarkers: Is There a Gold Standard for Diagnosis of Liver Fibrosis?
Clin Chem 2004 50: 1299-1300. [Extract] [Full Text] [PDF]  

Reviews:

Shawn D. Carrigan, George Scott, and Maryam Tabrizian

Toward Resolving the Challenges of Sepsis Diagnosis
Clin Chem 2004 50: 1301-1314. Published online May 27, 2004; 10.1373/clinchem.2004.032144 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Laura Soldati, Donatella Adamo, Cristiana Bianchin, Teresa Arcidiacono, Annalisa Terranegra, Maria Luisa Bianchi, Stefano Mora, Daniele Cusi, and Giuseppe Vezzoli

Vitamin D Receptor mRNA Measured in Leukocytes with the TaqMan Fluorogenic Detection System: Effect of Calcitriol Administration
Clin Chem 2004 50: 1315-1321. Published online May 20, 2004; 10.1373/clinchem.2004.033126 [Abstract] [Full Text] [PDF]  

Masato Maekawa, Tomonori Nagaoka, Terumi Taniguchi, Hitomi Higashi, Haruhiko Sugimura, Kokichi Sugano, Hiroyuki Yonekawa, Takatomo Satoh, Toshinobu Horii, Naohito Shirai, Akihiro Takeshita, and Takashi Kanno

Three-Dimensional Microarray Compared with PCR–Single-Strand Conformation Polymorphism Analysis/DNA Sequencing for Mutation Analysis of K-ras Codons 12 and 13
Clin Chem 2004 50: 1322-1327. Published online June 3, 2004; 10.1373/clinchem.2004.032060 [Abstract] [Full Text] [PDF] Data Supplement  

Luming Zhou, Alexander N. Myers, Joshua G. Vandersteen, Lesi Wang, and Carl T. Wittwer

Closed-Tube Genotyping with Unlabeled Oligonucleotide Probes and a Saturating DNA Dye
Clin Chem 2004 50: 1328-1335. Published online May 27, 2004; 10.1373/clinchem.2004.034322 [Abstract] [Full Text] [PDF]  

Stefania Stenirri, Isabella Fermo, Stefania Battistella, Silvia Galbiati, Nadia Soriani, Rita Paroni, Maria Pia Manitto, Elisabetta Martina, Rosario Brancato, Rando Allikmets, Maurizio Ferrari, and Laura Cremonesi

Denaturing HPLC Profiling of the ABCA4 Gene for Reliable Detection of Allelic Variations
Clin Chem 2004 50: 1336-1343. Published online June 10, 2004; 10.1373/clinchem.2004.033241 [Abstract] [Full Text] [PDF] Data Supplement  

Proteomics and Protein Markers:

Thierry Poynard, Mona Munteanu, Françoise Imbert-Bismut, Frederic Charlotte, Dominique Thabut, Sophie Le Calvez, Djamila Messous, Vincent Thibault, Yves Benhamou, Joseph Moussalli, and Vlad Ratziu

Prospective Analysis of Discordant Results between Biochemical Markers and Biopsy in Patients with Chronic Hepatitis C
Clin Chem 2004 50: 1344-1355. Published online June 10, 2004; 10.1373/clinchem.2004.032227 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Nicolai Grebenchtchikov, Arend Brinkman, Simone P.J. van Broekhoven, Danielle de Jong, Anneke Geurts-Moespot, Paul N. Span, Harry A. Peters, Henk Portengen, John A. Foekens, C.G.J. Sweep, and Lambert C.J. Dorssers

Development of an ELISA for Measurement of BCAR1 Protein in Human Breast Cancer Tissue
Clin Chem 2004 50: 1356-1363. [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Nader Rifai, Jing Ma, Frank M. Sacks, Paul M. Ridker, Wendy Jade L. Hernandez, Meir J. Stampfer, and Santica M. Marcovina

Apolipoprotein(a) Size and Lipoprotein(a) Concentration and Future Risk of Angina Pectoris with Evidence of Severe Coronary Atherosclerosis in Men: The Physicians’ Health Study
Clin Chem 2004 50: 1364-1371. Published online May 20, 2004; 10.1373/clinchem.2003.030031 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Robyn M. Jacob, Elaine C. Johnstone, Matt J. Neville, and Robert T. Walton

Identification of CYP2B6 Sequence Variants by Use of Multiplex PCR with Allele-Specific Genotyping
Clin Chem 2004 50: 1372-1377. Published online June 3, 2004; 10.1373/clinchem.2004.031708 [Abstract] [Full Text] [PDF] Data Supplement  

Endocrinology and Metabolism:

Xavier Palomer, Dídac Mauricio, José Rodríguez-Espinosa, Edgar Zapico, Carme Mayoral, Francesc González-Sastre, Alberto de Leiva, and Francisco Blanco-Vaca

Evaluation of Two Nonisotopic Immunoassays for Determination of Glutamic Acid Decarboxylase and Tyrosine Phosphatase Autoantibodies in Serum
Clin Chem 2004 50: 1378-1382. Published online May 20, 2004; 10.1373/clinchem.2004.031799 [Abstract] [Full Text] [PDF] Data Supplement  

Anke Sieg, Richard H. Guy, and M. Begoña Delgado-Charro

Noninvasive Glucose Monitoring by Reverse Iontophoresis in Vivo: Application of the Internal Standard Concept
Clin Chem 2004 50: 1383-1390. Published online May 20, 2004; 10.1373/clinchem.2004.032862 [Abstract] [Full Text] [PDF]  

Eduard A. Struys, Erwin E.W. Jansen, Nanda M. Verhoeven, and Cornelis Jakobs

Measurement of Urinary D- and L-2-Hydroxyglutarate Enantiomers by Stable-Isotope-Dilution Liquid Chromatography–Tandem Mass Spectrometry after Derivatization with Diacetyl-L-Tartaric Anhydride
Clin Chem 2004 50: 1391-1395. Published online May 27, 2004; 10.1373/clinchem.2004.033399 [Abstract] [Full Text] [PDF]  

Laboratory Management:

Marina Patriarca, Marco Castelli, Federica Corsetti, and Antonio Menditto

Estimate of Uncertainty of Measurement from a Single-Laboratory Validation Study: Application to the Determination of Lead in Blood
Clin Chem 2004 50: 1396-1405. Published online June 11, 2004; 10.1373/clinchem.2003.029223 [Abstract] [Full Text] [PDF]  

Nutrition:

Michelle M. Murphy, John M. Scott, Victoria Arija, Anne M. Molloy, and Joan D. Fernandez-Ballart

Maternal Homocysteine before Conception and throughout Pregnancy Predicts Fetal Homocysteine and Birth Weight
Clin Chem 2004 50: 1406-1412. Published online May 27, 2004; 10.1373/clinchem.2004.032904 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Attie T.J.I. Go, Allerdien Visser, Monique A.M. Mulders, Marinus A. Blankenstein, John M.G. van Vugt, and Cees B.M. Oudejans

Detection of Placental Transcription Factor mRNA in Maternal Plasma
Clin Chem 2004 50: 1413-1414. [Extract] [Full Text] [PDF] Data Supplement  

Michael Vogeser, Apostolos Kyriatsoulis, Erasmus Huber, and Uwe Kobold

Candidate Reference Method for the Quantification of Circulating 25-Hydroxyvitamin D₃ by Liquid Chromatography–Tandem Mass Spectrometry
Clin Chem 2004 50: 1415-1417. [Extract] [Full Text] [PDF]  

Yukie Nakashima, Kazunori Okano, Kyoko Kojima, Hiromi Shirakura, Shinichi Ishida, Masaki Watanabe, Kohshi Maeda, Hiroyuki Tsunoda, Yasushi Imai, and Keiichi Nagai

Convenient Single-Nucleotide Polymorphism Typing from Whole Blood by Probe Extension and Bioluminescence Detection
Clin Chem 2004 50: 1417-1420. [Extract] [Full Text] [PDF] Data Supplement  

Kirk Foster, Jennifer Moore, Kelly Hankins, Curtis A. Parvin, and Ann M. Gronowski

Effect of Blood Contamination on Delta 450 Bilirubin Measurement: An in Vitro Comparison of Two Corrective Methods
Clin Chem 2004 50: 1420-1422. [Extract] [Full Text] [PDF]  

Sofie Joossens, Marco Daperno, Zakera Shums, Kristel Van Steen, James A. Goeken, Claudio Trapani, Gary L. Norman, Godelieve Godefridis, Greet Claessens, Angelo Pera, Marie Pierik, Severine Vermeire, Paul Rutgeerts, and Xavier Bossuyt

Interassay and Interobserver Variability in the Detection of Anti-neutrophil Cytoplasmic Antibodies in Patients with Ulcerative Colitis
Clin Chem 2004 50: 1422-1425. [Extract] [Full Text] [PDF] Data Supplement  

Iman J. Schultz, Lambertus A. Kiemeney, Herbert F.M. Karthaus, J. Alfred Witjes, Johannes L. Willems, Dorine W. Swinkels, Jacqueline M.T. Klein Gunnewiek, and Jacques B. de Kok

Survivin mRNA Copy Number in Bladder Washings Predicts Tumor Recurrence in Patients with Superficial Urothelial Cell Carcinomas
Clin Chem 2004 50: 1425-1428. [Extract] [Full Text] [PDF]  

Xiongwen Yu, Chung S. Ho, and Christopher W.K. Lam

Biological Variation of Plasma F₂-Isoprostane-III and Arachidonic Acid in Healthy Individuals
Clin Chem 2004 50: 1428-1430. [Extract] [Full Text] [PDF]  

JoEtta M. Juenke, Paul I. Brown, Francis M. Urry, and Gwendolyn A. McMillin

Specimen Dilution for C2 Monitoring with the Abbott TDxFLx Cyclosporine Monoclonal Whole Blood Assay
Clin Chem 2004 50: 1430-1433. [Extract] [Full Text] [PDF]  

Raj Pandian, Laurence A. Cole, and Glenn E. Palomaki

Second-Trimester Maternal Serum Invasive Trophoblast Antigen: A Marker for Down Syndrome Screening
Clin Chem 2004 50: 1433-1435. Published online May 27, 2004; 10.1373/clinchem.2004.032839 [Extract] [Full Text] [PDF]  

Giulia Frisso, Antonella Carsana, Nadia Tinto, Giuseppe Calcagno, Francesco Salvatore, and Lucia Sacchetti

Direct Detection of Exon Deletions/Duplications in Female Carriers of and Male Patients with Duchenne/Becker Muscular Dystrophy
Clin Chem 2004 50: 1435-1438. [Extract] [Full Text] [PDF]  

Antonia Vlahou, Aris Giannopoulos, Betsy W. Gregory, Theodoros Manousakas, Filippos I. Kondylis, Lori L. Wilson, Paul F. Schellhammer, George L. Wright, Jr, and O. John Semmes

Protein Profiling in Urine for the Diagnosis of Bladder Cancer
Clin Chem 2004 50: 1438-1441. [Extract] [Full Text] [PDF] Data Supplement  

Zhilong Gong, Christine Teixeira, James Z. Xing, Jun Yokota, Takashi Kohno, Stephan Gabos, X. Chris Le, and Xing-Fang Li

Electronic Microarray Technique for Detection of Nine Base Substitutions Including Single-Nucleotide Polymorphisms in the Human OGG1 Gene
Clin Chem 2004 50: 1441-1444. [Extract] [Full Text] [PDF] Data Supplement  

Lambert C.J. Dorssers, Nicolai Grebenchtchikov, Arend Brinkman, Maxime P. Look, Jan G.M. Klijn, Anneke Geurts-Moespot, Paul N. Span, John A. Foekens, and C.G.J. Sweep

Application of a Newly Developed ELISA for BCAR1 Protein for Prediction of Clinical Benefit of Tamoxifen Therapy in Patients with Advanced Breast Cancer
Clin Chem 2004 50: 1445-1447. Published online May 27, 2004; 10.1373/clinchem.2004.035493 [Extract] [Full Text] [PDF]  

Ference J. Loupatty, Jos P.N. Ruiter, Lodewijk IJlst, Marinus Duran, and Ronald J.A. Wanders

Direct Nonisotopic Assay of 3-Methylglutaconyl-CoA Hydratase in Cultured Human Skin Fibroblasts to Specifically Identify Patients with 3-Methylglutaconic Aciduria Type I
Clin Chem 2004 50: 1447-1450. Published online June 10, 2004; 10.1373/clinchem.2004.033142 [Extract] [Full Text] [PDF]  

Fatma Meriç Yilmaz, Nermin Çelebi, and Dogan Yücel

Automated Turbidimetric Benzalkonium Chloride Method for Measurement of Protein in Urine and Cerebrospinal Fluid
Clin Chem 2004 50: 1450-1452. [Extract] [Full Text] [PDF]  

Terence C.W. Poon, K.C. Allen Chan, Pak-Cheung Ng, Rossa W.K. Chiu, Irene L. Ang, Yu-kwan Tong, Enders K.O. Ng, Frankie W.T. Cheng, Albert M. Li, Ellis K.L. Hon, Tai-Fai Fok, and Y.M. Dennis Lo

Serial Analysis of Plasma Proteomic Signatures in Pediatric Patients with Severe Acute Respiratory Syndrome and Correlation with Viral Load
Clin Chem 2004 50: 1452-1455. Published online June 3, 2004; 10.1373/clinchem.2004.035352 [Extract] [Full Text] [PDF] Data Supplement  

José Manuel Fernández-Real, Abel López-Bermejo, Montserrat Broch, Joan Vendrell, Cristobal Richart, and Wifredo Ricart

Circulating Soluble CD14 Monocyte Receptor Is Associated with Increased Alanine Aminotransferase
Clin Chem 2004 50: 1456-1458. [Extract] [Full Text] [PDF] Data Supplement  

Sébastien Cognat, David Cheillan, Monique Piraud, Birthe Roos, Cornelis Jakobs, and Christine Vianey-Saban

Determination of Guanidinoacetate and Creatine in Urine and Plasma by Liquid Chromatography–Tandem Mass Spectrometry
Clin Chem 2004 50: 1459-1461. [Extract] [Full Text] [PDF]  

Tim B. Menke, Katrin Boettcher, Stefan Krüger, Ingo Kausch, Andreas Boehle, Georg Sczakiel, and Jens M. Warnecke

Ki-67 Protein Concentrations in Urothelial Bladder Carcinomas Are Related to Ki-67-Specific RNA Concentrations in Urine
Clin Chem 2004 50: 1461-1463. [Extract] [Full Text] [PDF] Data Supplement  

Meeting Report:

Maureen Cronin, Krishna Ghosh, Frank Sistare, John Quackenbush, Vincent Vilker, and Catherine O’Connell

Universal RNA Reference Materials for Gene Expression
Clin Chem 2004 50: 1464-1471. Published online May 20, 2004; 10.1373/clinchem.2004.035675 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Yuki Futatsugawa, Takahiro Kubota, Akihiro Ishiguro, Hiroshi Suzuki, Hiroshi Ishikawa, and Tatsuji Iga

PCR-Based Haplotype Determination to Distinguish CYP2B6*1/*7 and *5/*6
Clin Chem 2004 50: 1472-1473. [Extract] [Full Text] [PDF]  

Koenraad Gijbels, Johan De Coster, and Xavier Bossuyt

Interference by Gelatin-Based Plasma Substitutes in Capillary Zone Electrophoresis
Clin Chem 2004 50: 1473-1475. [Extract] [Full Text] [PDF] Data Supplement  

William E. Grizzle, Sreelatha Meleth, Emanuel F. Petricoin, and Lance A. Liotta

Clarification in the Point/Counterpoint Discussion Related to Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometric Identification of Patients with Adenocarcinomas of the Prostate • Proteomic Pattern Complexity Reveals a Rich and Uncharted Continent of Biomarkers
Clin Chem 2004 50: 1475-1477. [Extract] [Full Text] [PDF] Data Supplement  

Fred S. Apple and MaryAnn M. Murakami

Serum 99th Percentile Reference Cutoffs for Seven Cardiac Troponin Assays
Clin Chem 2004 50: 1477-1479. [Extract] [Full Text] [PDF]  

Yoshinori Hasegawa, Takeshi Sarashina, Maki Ando, Chiyoe Kitagawa, Atsuo Mori, Masao Yoneyama, Yuichi Ando, and Kaoru Shimokata

Rapid Detection of UGT1A1 Gene Polymorphisms by Newly Developed Invader Assay
Clin Chem 2004 50: 1479-1480. [Extract] [Full Text] [PDF] Data Supplement  

Masato Maekawa, Terumi Taniguchi, Hitomi Higashi, Haruhiko Sugimura, Kokichi Sugano, and Takashi Kanno

Methylation of Mitochondrial DNA Is Not a Useful Marker for Cancer Detection
Clin Chem 2004 50: 1480-1481. [Extract] [Full Text] [PDF]  

Ashley Townsend, Alison Featherstone, Cyrille C. Chéry, Frank Vanhaecke, Jason Kirby, Frank Krikowa, Bill Maher, Glenn Jacobson, and Gregory Peterson

Increased Selenium Concentrations in Seronorm Trace Elements Serum (Level 2)
Clin Chem 2004 50: 1481-1482. [Extract] [Full Text] [PDF]  

Eric J. Norman

Urinary Methylmalonic Acid Test May Have Greater Value than the Total Homocysteine Assay for Screening Elderly Individuals for Cobalamin Deficiency
Clin Chem 2004 50: 1482-1483. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Len Herzenberg

Optical Methods: A Guide to the "-Escences". Larry J. Kricka. Washington, DC: AACC Press, 2003, 191 pp., $35.00 ($28.00 AACC members), softcover. ISBN 1-890883-91-3.
Clin Chem 2004 50: 1484. [Extract] [Full Text] [PDF]  

Michael Welch

Sample Preparation Techniques in Analytical Chemistry. Somenath Mitra, editor. Hoboken, NJ: Wiley-Interscience, 2003, 476 pp., $89.95, hardcover. ISBN 0-471-32845-6.
Clin Chem 2004 50: 1484-1485. [Extract] [Full Text] [PDF]  

Thomas J. Manning

Laboratory Evaluation of the Poisoned Patient—A Teaching Slide Set. Tai C. Kwong, Thomas P. Moyer, Paul J. Orsulak, Thomas G. Rosano, and Leslie M. Shaw, editors. Washington, DC: AACC Press, 2003, $35.00 ($28.00 AACC members), CD. ISBN 1-890883-92-1.
Clin Chem 2004 50: 1484. [Extract] [Full Text] [PDF]  

Corrections:

Correction for Volume 50, Issue , p. 451
Clin Chem 2004 50: 1485. [Extract] [Full Text] [PDF]  

Obituary:

Nathan Gochman

Arnold O. Beckman, PhD (1900–2004)
Clin Chem 2004 50: 1486-1487. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Clin Chem 2004 50: 1488. [Extract] [Full Text] [PDF]  

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