Editorials:

Nicolas von Ahsen

Two for Typing: Homogeneous Combined Single-Nucleotide Polymorphism Scanning and Genotyping
Clin Chem 2005 51: 1761-1762. [Extract] [Full Text] [PDF]  

D. Robert Dufour

Assessment of Liver Fibrosis: Can Serum Become the Sample of Choice?
Clin Chem 2005 51: 1763-1764. [Extract] [Full Text] [PDF]  

Laurence A. Cole

"Background" Human Chorionic Gonadotropin in Healthy, Nonpregnant Women
Clin Chem 2005 51: 1765-1766. [Extract] [Full Text] [PDF]  

Larry J. Kricka and Jason Y. Park

Additive-Aggravated Assays: An Authoritative Answer
Clin Chem 2005 51: 1767. [Extract] [Full Text] [PDF]  

Joakim Dillner

Toward "Serolomics": Papillomavirus Serology Is Taking a Technologic Lead in High-Throughput Multiplexed Antibody Analysis
Clin Chem 2005 51: 1768-1769. [Extract] [Full Text] [PDF]  

Proteomics and Protein Markers:

David E. Amacher, Rick Adler, Athula Herath, and R. Reid Townsend

Use of Proteomic Methods to Identify Serum Biomarkers Associated with Rat Liver Toxicity or Hypertrophy
Clin Chem 2005 51: 1796-1803. Published online August 11, 2005; 10.1373/clinchem.2005.049908 [Abstract] [Full Text] [PDF] Data Supplements  

Molecular Diagnostics and Genetics:

Luming Zhou, Lesi Wang, Robert Palais, Robert Pryor, and Carl T. Wittwer

High-Resolution DNA Melting Analysis for Simultaneous Mutation Scanning and Genotyping in Solution
Clin Chem 2005 51: 1770-1777. [Abstract] [Full Text] [PDF] Data Supplement  

Catherine J. Chase, Melanie P. Ulrich, Leonard P. Wasieloski, Jr, John P. Kondig, Jeffrey Garrison, Luther E. Lindler, and David A. Kulesh

Real-Time PCR Assays Targeting a Unique Chromosomal Sequence of Yersinia pestis
Clin Chem 2005 51: 1778-1785. Published online August 11, 2005; 10.1373/clinchem.2005.051839 [Abstract] [Full Text] [PDF] Data Supplements  

Blenda C.K. Wong, Rossa W.K. Chiu, Nancy B.Y. Tsui, K.C. Allen Chan, Lin W. Chan, Tze K. Lau, Tse N. Leung, and Y.M. Dennis Lo

Circulating Placental RNA in Maternal Plasma Is Associated with a Preponderance of 5' mRNA Fragments: Implications for Noninvasive Prenatal Diagnosis and Monitoring
Clin Chem 2005 51: 1786-1795. Published online August 4, 2005; 10.1373/clinchem.2005.052340 [Abstract] [Full Text] [PDF] Data Supplement  

Automation and Analytical Techniques:

Régis Peytavi, Frédéric R. Raymond, Dominic Gagné, François J. Picard, Guangyao Jia, Jim Zoval, Marc Madou, Karel Boissinot, Maurice Boissinot, Luc Bissonnette, Marc Ouellette, and Michel G. Bergeron

Microfluidic Device for Rapid (<15 min) Automated Microarray Hybridization
Clin Chem 2005 51: 1836-1844. Published online August 17, 2005; 10.1373/clinchem.2005.052845 [Abstract] [Full Text] [PDF]  

Tim Waterboer, Peter Sehr, Kristina M. Michael, Silvia Franceschi, John D. Nieland, Thomas O. Joos, Markus F. Templin, and Michael Pawlita

Multiplex Human Papillomavirus Serology Based on In Situ–Purified Glutathione S-Transferase Fusion Proteins
Clin Chem 2005 51: 1845-1853. Published online August 11, 2005; 10.1373/clinchem.2005.052381 [Abstract] [Full Text] [PDF]  

Kristin Skogstrand, Poul Thorsen, Bent Nørgaard-Pedersen, Diana E. Schendel, Line C. Sørensen, and David M. Hougaard

Simultaneous Measurement of 25 Inflammatory Markers and Neurotrophins in Neonatal Dried Blood Spots by Immunoassay with xMAP Technology
Clin Chem 2005 51: 1854-1866. Published online August 4, 2005; 10.1373/clinchem.2005.052241 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Masahiko Okada, Tomohiro Saito, Hajime Yoshimura, Yasuhiko Noguchi, Taeko Ito, Hiroko Sasaki, and Hitoshi Hama

Surfactant-Based Homogeneous Assay for the Measurement of Triglyceride Concentrations in VLDL and Intermediate-Density Lipoprotein
Clin Chem 2005 51: 1804-1810. Published online August 4, 2005; 10.1373/clinchem.2005.049304 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Frank T. Peters, Nele Samyn, Caroline T.J. Lamers, Wim J. Riedel, Thomas Kraemer, Gert de Boeck, and Hans H. Maurer

Drug Testing in Blood: Validated Negative-Ion Chemical Ionization Gas Chromatographic–Mass Spectrometric Assay for Enantioselective Measurement of the Designer Drugs MDEA, MDMA, and MDA and Its Application to Samples from a Controlled Study with MDMA
Clin Chem 2005 51: 1811-1822. Published online August 11, 2005; 10.1373/clinchem.2005.052746 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Nils G. Morgenthaler, Joachim Struck, Christine Alonso, and Andreas Bergmann

Measurement of Midregional Proadrenomedullin in Plasma with an Immunoluminometric Assay
Clin Chem 2005 51: 1823-1829. Published online August 11, 2005; 10.1373/clinchem.2005.051110 [Abstract] [Full Text] [PDF]  

Jennifer A. Snyder, Shannon Haymond, Curtis A. Parvin, Ann M. Gronowski, and David G. Grenache

Diagnostic Considerations in the Measurement of Human Chorionic Gonadotropin in Aging Women
Clin Chem 2005 51: 1830-1835. Published online August 11, 2005; 10.1373/clinchem.2005.053595 [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Leon A. Adams, Max Bulsara, Enrico Rossi, Bastiaan DeBoer, David Speers, Jacob George, James Kench, Geoffrey Farrell, Geoffrey W. McCaughan, and Gary P. Jeffrey

Hepascore: An Accurate Validated Predictor of Liver Fibrosis in Chronic Hepatitis C Infection
Clin Chem 2005 51: 1867-1873. Published online July 28, 2005; 10.1373/clinchem.2005.048389 [Abstract] [Full Text] [PDF]  

Raffick A.R. Bowen, Yung Chan, Mark E. Ruddel, Glen L. Hortin, Gyorgy Csako, Stephen J. Demosky, Jr, and Alan T. Remaley

Immunoassay Interference by a Commonly Used Blood Collection Tube Additive, the Organosilicone Surfactant Silwet L-720
Clin Chem 2005 51: 1874-1882. Published online August 11, 2005; 10.1373/clinchem.2005.055400 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Armando Tripodi, Maria Elisa Mancuso, Veena Chantarangkul, Marigrazia Clerici, Rossella Bader, Pier Luigi Meroni, Elena Santagostino, and Pier Mannuccio Mannucci

Lupus Anticoagulants and Their Relationship with the Inhibitors against Coagulation Factor VIII: Considerations on the Differentiation between the 2 Circulating Anticoagulants
Clin Chem 2005 51: 1883-1885. Published online August 11, 2005; 10.1373/clinchem.2005.054312 [Extract] [Full Text] [PDF]  

Shea Ping Yip, Shing Shun T. To, Polly H.M. Leung, Tsz Shan Cheung, Peter K.C. Cheng, and Wilina W.L. Lim

Use of Dual TaqMan Probes to Increase the Sensitivity of 1-Step Quantitative Reverse Transcription-PCR: Application to the Detection of SARS Coronavirus
Clin Chem 2005 51: 1885-1888. [Extract] [Full Text] [PDF]  

Ariane Luyckx, René Westhovens, Els Oris, Wolfgang Papisch, and Xavier Bossuyt

Clinical Relevance of Measurement of Antibodies to Individual snU₁-RNP Proteins
Clin Chem 2005 51: 1888-1890. Published online August 11, 2005; 10.1373/clinchem.2005.053652 [Extract] [Full Text] [PDF]  

Paul J. Taylor, Scott R. Brown, Donald P. Cooper, Paul Salm, Michael R. Morris, Peter I. Pillans, and Stephen V. Lynch

Evaluation of 3 Internal Standards for the Measurement of Cyclosporin by HPLC–Mass Spectrometry
Clin Chem 2005 51: 1890-1893. [Extract] [Full Text] [PDF] Data Supplements  

Anna Stefánska, Grazyna Sypniewskay, and Lilla Senterkiewicz

Inflammatory Markers and Cardiovascular Risk in Healthy Polish Women across the Menopausal Transition
Clin Chem 2005 51: 1893-1895. [Extract] [Full Text] [PDF]  

History:

Richard M. Rocco

Joachim Kohn (1912–1987) and the Origin of Cellulose Acetate Electrophoresis
Clin Chem 2005 51: 1896-1901. Published online August 11, 2005; 10.1373/clinchem.2005.056572 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Juan Carlos Kaski, Pablo Avanzas, and Ramón Arroyo-Espliguero

Neopterin: Still a Forgotten Biomarker
Clin Chem 2005 51: 1902-1903. [Extract] [Full Text] [PDF]  

Fred S. Apple

Neopterin: Still a Forgotten Biomarker: Dr. Apple responds
Clin Chem 2005 51: 1903. [Extract] [Full Text] [PDF] Data Supplements  

Ying Li, Deirdré Hahn, Wolfgang Holzgreve, and Sinuhe Hahn

Ready Detection of Donor-Specific Single-Nucleotide Polymorphisms in the Urine of Renal Transplant Recipients by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Clin Chem 2005 51: 1903-1904. [Extract] [Full Text] [PDF]  

David Waskiewicz, Alan Burkhardt, and Kenneth Emancipator

Performance Characteristics of 6 Third-Generation Assays for Thyroid-Stimulating Hormone
Clin Chem 2005 51: 1904-1905. [Extract] [Full Text] [PDF]  

William L. Roberts

Performance Characteristics of 6 Third-Generation Assays for Thyroid-Stimulating Hormone: Dr. Roberts responds
Clin Chem 2005 51: 1905. [Extract] [Full Text] [PDF]  

Li Wei Cho, Vijay Jayagopal, Eric S. Kilpatrick, and Stephen L. Atkin

The Biological Variation of C-Reactive Protein in Polycystic Ovarian Syndrome
Clin Chem 2005 51: 1905-1907. [Extract] [Full Text] [PDF]  

Marc-Alexander von Mach, Ludwig Sacha Weilemann, and Philipp von Landenberg

Pseudocholinesterase Activity in Organophosphate Poisoning after Storage of Unseparated Blood Samples at Room Temperature for 3 Weeks
Clin Chem 2005 51: 1907-1908. [Extract] [Full Text] [PDF]  

Ahinoam Lev-Sagie, Benjamin Bar-Oz, Lea Salpeter, Drorith Hochner-Celnikier, Ilan Arad, and Amiram Nir

Plasma Concentrations of N-Terminal Pro-B-Type Natriuretic Peptide in Pregnant Women near Labor and during Early Puerperium
Clin Chem 2005 51: 1909-1910. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Fred D. Lasky

CLIA Final Rules for Quality Systems: Quality Assessment Issues and Answers. James O. Westgard, Sharon S. Ehrmeyer, and Teresa P. Darcy. Madison, WI: Westgard QC, Inc., 2004, 225 pp., softcover, $60.00 ($50.00 AACC members). ISBN 1-886958-20-3.
Clin Chem 2005 51: 1911-1912. [Extract] [Full Text] [PDF]  

Jim Pearson

Introduction to Weapons of Mass Destruction: Radiological, Chemical, and Biological. R. Everett Langford. Hoboken, NJ: Wiley-Interscience; John Wiley & Sons, Inc., 2004, 410 pp., $89.95, hardcover. ISBN 0-471-46560-7.
Clin Chem 2005 51: 1912. [Extract] [Full Text] [PDF]  

Bin Chen

The Dictionary of Gene Technology: Genomics, Transcriptomics, Proteomics, Third, Revised and Enlarged Edition, Volumes 1 and 2. Günter Kahl. Weinheim, Federal Republic of Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2004, 1292 pp., $230.00, cloth. ISBN 3527307656.
Clin Chem 2005 51: 1912-1913. [Extract] [Full Text] [PDF]  

Oak Ridge Conference:

Joseph R. Lakowicz, Joanna Malicka, Evgenia Matveeva, Ignacy Gryczynski, and Zygmunt Gryczynski

Plasmonic Technology: Novel Approach to Ultrasensitive Immunoassays
Clin Chem 2005 51: 1914-1922. Published online July 28, 2005; 10.1373/clinchem.2005.053199 [Abstract] [Full Text] [PDF]  

Michael J. Pugia, Gert Blankenstein, Ralf-Peter Peters, James A. Profitt, Klaus Kadel, Thomas Willms, Ronald Sommer, Hai Hang Kuo, and Lloyd S. Schulman

Microfluidic Tool Box as Technology Platform for Hand-Held Diagnostics
Clin Chem 2005 51: 1923-1932. Published online July 28, 2005; 10.1373/clinchem.2005.052498 [Abstract] [Full Text] [PDF]  

Mark S. Lowenthal, Arpita I. Mehta, Kristina Frogale, Russell W. Bandle, Robyn P. Araujo, Brian L. Hood, Timothy D. Veenstra, Thomas P. Conrads, Paul Goldsmith, David Fishman, Emanuel F. Petricoin, III, and Lance A. Liotta

Analysis of Albumin-Associated Peptides and Proteins from Ovarian Cancer Patients
Clin Chem 2005 51: 1933-1945. Published online August 11, 2005; 10.1373/clinchem.2005.052944 [Abstract] [Full Text] [PDF] Data Supplement  

Mary F. Lopez, Alvydas Mikulskis, Scott Kuzdzal, David A. Bennett, Jeremiah Kelly, Eva Golenko, Joseph DiCesare, Eric Denoyer, Wayne F. Patton, Richard Ediger, Lisa Sapp, Tillmann Ziegert, Christopher Lynch, Susan Kramer, Gordon R. Whiteley, Michael R. Wall, David P. Mannion, Guy della Cioppa, John S. Rakitan, and Gershon M. Wolfe

High-Resolution Serum Proteomic Profiling of Alzheimer Disease Samples Reveals Disease-Specific, Carrier-Protein–Bound Mass Signatures
Clin Chem 2005 51: 1946-1954. Published online August 4, 2005; 10.1373/clinchem.2005.053090 [Abstract] [Full Text] [PDF]  

Nobuo Honda, Ulrika Lindberg, Per Andersson, Stephan Hoffmann, and Hiroyuki Takei

Simultaneous Multiple Immunoassays in a Compact Disc–Shaped Microfluidic Device Based on Centrifugal Force
Clin Chem 2005 51: 1955-1961. Published online August 4, 2005; 10.1373/clinchem.2005.053348 [Abstract] [Full Text] [PDF]  

Benjamin Godber, Kevin S.J. Thompson, Marian Rehak, Yildiz Uludag, Sven Kelling, Alexander Sleptsov, Mark Frogley, Klaus Wiehler, Christopher Whalen, and Matthew A. Cooper

Direct Quantification of Analyte Concentration by Resonant Acoustic Profiling
Clin Chem 2005 51: 1962-1972. Published online August 4, 2005; 10.1373/clinchem.2005.053249 [Abstract] [Full Text] [PDF]  

Nurith Kurn, Pengchin Chen, Joe Don Heath, Anne Kopf-Sill, Kathryn M. Stephens, and Shenglong Wang

Novel Isothermal, Linear Nucleic Acid Amplification Systems for Highly Multiplexed Applications
Clin Chem 2005 51: 1973-1981. Published online August 25, 2005; 10.1373/clinchem.2005.053694 [Abstract] [Full Text] [PDF] Data Supplements  

Abstracts of Oak Ridge Posters:

Emanuela Orlandi, Asif Butt, David Goldsmith, and R. Swaminathan

Factors Affecting Circulating mRNA for Nephrin
Clin Chem 2005 51: 1982-1983. [Extract] [Full Text] [PDF]  

Michael Moxness, Suzanna Tatarewicz, Dohan Weeraratne, Nancy Murakami, Danika Wullner, Dan Mytych, Vibha Jawa, Eugen Koren, and Steven J. Swanson

Immunogenicity Testing by Electrochemiluminescent Detection for Antibodies Directed against Therapeutic Human Monoclonal Antibodies
Clin Chem 2005 51: 1983-1985. [Extract] [Full Text] [PDF]  

Mats Inganäs, Helene Dérand, Ann Eckersten, Gunnar Ekstrand, Ann-Kristin Honerud, Gerald Jesson, Gunnar Thorsén, Tobias Söderman, and Per Andersson

Integrated Microfluidic Compact Disc Device with Potential Use in Both Centralized and Point-of-Care Laboratory Settings
Clin Chem 2005 51: 1985-1987. Published online August 11, 2005; 10.1373/clinchem.2005.053181 [Extract] [Full Text] [PDF]  

Chao Dou, Dongyuan Xia, Liqing Zhang, Xiaoru Chen, Patrick Flores, Abhijit Datta, and Chong Yuan

Development of a Novel Enzymatic Cycling Assay for Total Homocysteine
Clin Chem 2005 51: 1987-1989. [Extract] [Full Text] [PDF]  

Chao Dou, Olga Aleshin, Abhijit Datta, and Chong Yuan

Automated Enzymatic Assay for Measurement of Lithium Ions in Human Serum
Clin Chem 2005 51: 1989-1991. [Extract] [Full Text] [PDF]  

Yuping Wang, Chao Dou, Chong Yuan, and Abhijit Datta

Development of an Automated Enzymatic Assay for the Determination of Glycated Serum Protein in Human Serum
Clin Chem 2005 51: 1991-1992. [Extract] [Full Text] [PDF]  

Aldo Roda, Mara Mirasoli, Dora Melucci, and Pierluigi Reschiglian

Toward Multianalyte Immunoassays: A Flow-Assisted, Solid-Phase Format with Chemiluminescence Detection
Clin Chem 2005 51: 1993-1995. [Extract] [Full Text] [PDF]  

Elisa Michelini, Maria Magliulo, Piia Leskinen, Marko Virta, Matti Karp, and Aldo Roda

Recombinant Cell-Based Bioluminescence Assay for Androgen Bioactivity Determination in Clinical Samples
Clin Chem 2005 51: 1995-1998. [Extract] [Full Text] [PDF]  

Abstracts for CNAPS IV:

Circulating Nucleic Acids in Plasma/Serum: London, September 4–6, 2005
Clin Chem 2005 51: 1999. [Extract] [Full Text] [PDF] Abstracts for CNAPS IV  

The Clinical Chemist:

David E. Bruns

The Clinical Chemist
Clin Chem 2005 51: 2000. [Extract] [Full Text] [PDF]  

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