Editorials:

David K. Stevenson, Ronald J. Wong, and Hendrik J. Vreman

Reduction in Hospital Readmission Rates for Hyperbilirubinemia Is Associated with Use of Transcutaneous Bilirubin Measurements
Clin Chem 2005 51: 481-482. [Extract] [Full Text] [PDF]  

Craig M. Jackson and M. Peter Esnouf

Has the Time Arrived to Replace the Quick Prothrombin Time Test for Monitoring Oral Anticoagulant Therapy?
Clin Chem 2005 51: 483-485. [Extract] [Full Text] [PDF]  

Special Reports:

Fred S. Apple, Mauro Panteghini, Jan Ravkilde, Johannes Mair, Alan H.B. Wu, Jillian Tate, Franca Pagani, Robert H. Christenson, Allan S. Jaffe on Behalf of the Committee on Standardization of Markers of Cardiac Damage of the IFCC

Quality Specifications for B-Type Natriuretic Peptide Assays
Clin Chem 2005 51: 486-493. [Abstract] [Full Text] [PDF]  

Review:

Michael J. Duffy

Predictive Markers in Breast and Other Cancers: A Review
Clin Chem 2005 51: 494-503. Published online January 6, 2005; 10.1373/clinchem.2004.046227 [Abstract] [Full Text] [PDF]  

Opinion:

Nader Rifai

High-Sensitivity C-Reactive Protein: A Useful Marker for Cardiovascular Disease Risk Prediction and the Metabolic Syndrome
Clin Chem 2005 51: 504-505. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Iacovos P. Michael, Lisa Kurlender, Nader Memari, George M. Yousef, Daisy Du, Linda Grass, Carsten Stephan, Klaus Jung, and Eleftherios P. Diamandis

Intron Retention: A Common Splicing Event within the Human Kallikrein Gene Family
Clin Chem 2005 51: 506-515. Published online January 13, 2005; 10.1373/clinchem.2004.042341 [Abstract] [Full Text] [PDF] Data Supplement  

Saskia Z.H. Rittersma, Johanna A. Kremer Hovinga, Karel T. Koch, S. Matthijs Boekholdt, Benien E. van Aken, Arko Scheepmaker, Matthijs Bax, Carl E. Schotborgh, Jan J. Piek, Jan G.P. Tijssen, Pieter H. Reitsma, and Robbert J. de Winter

Relationship between In Vitro Lipopolysaccharide-Induced Cytokine Response in Whole Blood, Angiographic In-Stent Restenosis, and Toll-Like Receptor 4 Gene Polymorphisms
Clin Chem 2005 51: 516-521. Published online January 13, 2005; 10.1373/clinchem.2004.041277 [Abstract] [Full Text] [PDF]  

Erik Söderbäck, Anna-Lena Zackrisson, Bertil Lindblom, and Anders Alderborn

Determination of CYP2D6 Gene Copy Number by Pyrosequencing
Clin Chem 2005 51: 522-531. Published online January 13, 2005; 10.1373/clinchem.2004.043182 [Abstract] [Full Text] [PDF]  

Evidence-based Laboratory Medicine and Test Utilization:

Thomas Keller, Hermann Butz, Michael Lein, Maciej Kwiatkowski, Axel Semjonow, Hans-Joachim Luboldt, Peter Hammerer, Carsten Stephan, and Klaus Jung

Discordance Analysis Characteristics as a New Method to Compare the Diagnostic Accuracy of Tests: Example of Complexed Versus Total Prostate-Specific Antigen
Clin Chem 2005 51: 532-539. [Abstract] [Full Text] [PDF]  

John R. Petersen, Anthony O. Okorodudu, Amin A. Mohammad, Amarasiri Fernando, and Karen E. Shattuck

Association of Transcutaneous Bilirubin Testing in Hospital with Decreased Readmission Rate for Hyperbilirubinemia
Clin Chem 2005 51: 540-544. [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

Junzo Nojima, Hirohiko Kuratsune, Etsuji Suehisa, Yoshinori Iwatani, and Yuzuru Kanakura

Acquired Activated Protein C Resistance Associated with IgG Antibodies against ß₂-Glycoprotein I and Prothrombin as a Strong Risk Factor for Venous Thromboembolism
Clin Chem 2005 51: 545-552. Published online January 6, 2005; 10.1373/clinchem.2004.043414 [Abstract] [Full Text] [PDF]  

Juha Horsti, Helena Uppa, and Juhani A Vilpo

Poor Agreement among Prothrombin Time International Normalized Ratio Methods: Comparison of Seven Commercial Reagents
Clin Chem 2005 51: 553-560. Published online January 21, 2005; 10.1373/clinchem.2004.043836 [Abstract] [Full Text] [PDF]  

Johanna H.H. van Geest-Daalderop, André B. Mulder, Leandra J.M. Boonman-de Winter, Martha M.C.L. Hoekstra, and Anton M.H.P. van den Besselaar

Preanalytical Variables and Off-Site Blood Collection: Influences on the Results of the Prothrombin Time/International Normalized Ratio Test and Implications for Monitoring of Oral Anticoagulant Therapy
Clin Chem 2005 51: 561-568. Published online January 13, 2005; 10.1373/clinchem.2004.043174 [Abstract] [Full Text] [PDF] Data Supplement  

Proteomics and Protein Markers:

Wayne L. Miller, Karen A. Hartman, Mary F. Burritt, Daniel D. Borgeson, John C. Burnett, Jr, and Allan S. Jaffe

Biomarker Responses during and after Treatment with Nesiritide Infusion in Patients with Decompensated Chronic Heart Failure
Clin Chem 2005 51: 569-577. Published online December 22, 2004; 10.1373/clinchem.2004.041582 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Dick C. Chan, Gerald F. Watts, Theodore W.K. Ng, Yoshiaki Uchida, Naohiko Sakai, Shizuya Yamashita, and P. Hugh R. Barrett

Adiponectin and other Adipocytokines as Predictors of Markers of Triglyceride-Rich Lipoprotein Metabolism
Clin Chem 2005 51: 578-585. Published online January 13, 2005; 10.1373/clinchem.2004.045120 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Nigel W. Brown, Christopher E. Gonde, Jemimah E. Adams, and J. Michael Tredger

Low Hematocrit and Serum Albumin Concentrations Underlie the Overestimation of Tacrolimus Concentrations by Microparticle Enzyme Immunoassay versus Liquid Chromatography–Tandem Mass Spectrometry
Clin Chem 2005 51: 586-592. Published online January 13, 2005; 10.1373/clinchem.2004.043950 [Abstract] [Full Text] [PDF] Data Supplement  

Olivier Nicolas, Christine Farenc, Michèle Calas, Henri J. Vial, and Françoise Bressolle

Quantification of Antimalarial Bisthiazolium Compounds and Their Neutral Bioprecursors in Plasma by Liquid Chromatography-Electrospray Mass Spectrometry
Clin Chem 2005 51: 593-602. Published online January 6, 2005; 10.1373/clinchem.2004.042580 [Abstract] [Full Text] [PDF] Data Supplement  

Endocrinology and Metabolism:

José-Manuel Fernández-Real, Joan Vendrell, and Wifredo Ricart

Circulating Adiponectin and Plasma Fatty Acid Profile
Clin Chem 2005 51: 603-609. Published online January 6, 2005; 10.1373/clinchem.2004.041350 [Abstract] [Full Text] [PDF]  

Stanley H. Korman, Brage S. Andresen, Avraham Zeharia, Alisa Gutman, Avihu Boneh, and James J. Pitt

2-Ethylhydracrylic Aciduria in Short/Branched-Chain Acyl-CoA Dehydrogenase Deficiency: Application to Diagnosis and Implications for the R-Pathway of Isoleucine Oxidation
Clin Chem 2005 51: 610-617. Published online December 22, 2004; 10.1373/clinchem.2004.043265 [Abstract] [Full Text] [PDF]  

Kaisa K. Ivaska, Sanna-Maria Käkönen, Paul Gerdhem, Karl J. Obrant, Kim Pettersson, and H. Kalervo Väänänen

Urinary Osteocalcin as a Marker of Bone Metabolism
Clin Chem 2005 51: 618-628. Published online January 13, 2005; 10.1373/clinchem.2004.043901 [Abstract] [Full Text] [PDF] Data Supplement  

Nutrition:

Valerie A. Holmes, Julie M.W. Wallace, H. Denis Alexander, William S. Gilmore, Ian Bradbury, Mary Ward, John M. Scott, Peter McFaul, and Helene McNulty

Homocysteine Is Lower in the Third Trimester of Pregnancy in Women with Enhanced Folate Status from Continued Folic Acid Supplementation
Clin Chem 2005 51: 629-634. Published online December 22, 2004; 10.1373/clinchem.2004.032698 [Abstract] [Full Text] [PDF] Data Supplement  

Technical Briefs:

Xiao Yan Zhong, Wolfgang Holzgreve, Irene Hoesli, and Sinuhe Hahn

Circulatory Corticotropin-Releasing Hormone mRNA Concentrations Are Increased in Women with Preterm Delivery But Not in Those Who Respond to Tocolytic Treatment
Clin Chem 2005 51: 635-636. [Extract] [Full Text] [PDF]  

André Reuland, Andreas Humeny, Achim Magener, Cord-Michael Becker, and Katrin Schiebel

Detection of Loss of Heterozygosity by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry-Based Analysis of Single-Nucleotide Polymorphisms
Clin Chem 2005 51: 636-639. [Extract] [Full Text] [PDF] Data Supplements  

Margarette Jane Ellis and John Hamilton Livesey

Techniques for Identifying Heterophile Antibody Interference Are Assay Specific: Study of Seven Analytes on Two Automated Immunoassay Analyzers
Clin Chem 2005 51: 639-641. Published online January 13, 2005; 10.1373/clinchem.2004.043869 [Extract] [Full Text] [PDF]  

Pranee Sutcharitchan, Wen Wang, Rung Settapiboon, Supaporn Amornsiriwat, Arnold S.C. Tan, and Samuel S. Chong–

Hemoglobin H Disease Classification by Isoelectric Focusing: Molecular Verification of 110 Cases from Thailand
Clin Chem 2005 51: 641-644. Published online January 13, 2005; 10.1373/clinchem.2004.044396 [Extract] [Full Text] [PDF] Data Supplement  

Srinivas B. Narayan, Richard L. Boriack, Bette Messmer, and Michael J. Bennett

Establishing a Reference Interval For Measurement of Flux through the Mitochondrial Fatty Acid Oxidation Pathway in Cultured Skin Fibroblasts
Clin Chem 2005 51: 644-646. [Extract] [Full Text] [PDF] Data Supplements  

Ferruh Isman, Glenn E. Palomaki, and Marvin R. Natowicz

Lysosomal Enzymes in Human Peripheral Blood Mononuclear Cells and Granulocytes
Clin Chem 2005 51: 646-649. Published online January 6, 2005; 10.1373/clinchem.2004.045930 [Extract] [Full Text] [PDF]  

Roland Kindich, Andrea R. Florl, Volker Jung, Rainer Engers, Mirko Müller, Wolfgang A. Schulz, and Bernd Wullich

Application of a Modified Real-Time PCR Technique for Relative Gene Copy Number Quantification to the Determination of the Relationship between NKX3.1 Loss and MYC Gain in Prostate Cancer
Clin Chem 2005 51: 649-652. [Extract] [Full Text] [PDF] Data Supplement  

Satheesh Kumar Reddy Chinnapapagari, Wolfgang Holzgreve, Olav Lapaire, Bernhard Zimmermann, and Sinuhe Hahn

Treatment of Maternal Blood Samples with Formaldehyde Does Not Alter the Proportion of Circulatory Fetal Nucleic Acids (DNA and mRNA) in Maternal Plasma
Clin Chem 2005 51: 652-655. [Extract] [Full Text] [PDF]  

Grace T.Y. Chung, Rossa W.K. Chiu, K.C. Allen Chan, Tze K. Lau, Tse N. Leung, and Y.M. Dennis Lo

Lack of Dramatic Enrichment of Fetal DNA in Maternal Plasma by Formaldehyde Treatment
Clin Chem 2005 51: 655-658. [Extract] [Full Text] [PDF]  

Angelo Zinellu, Salvatore Sotgia, Luca Deiana, and Ciriaco Carru

Quantification of Thiol-Containing Amino Acids Linked by Disulfides to LDL
Clin Chem 2005 51: 658-660. [Extract] [Full Text] [PDF]  

History:

Thomas R. Gingeras, Russell Higuchi, Larry J. Kricka, Y.M. Dennis Lo, and Carl T. Wittwer

Fifty Years of Molecular (DNA/RNA) Diagnostics
Clin Chem 2005 51: 661-671. Published online January 13, 2005; 10.1373/clinchem.2004.045336 [Extract] [Full Text] [PDF]  

Letters to the Editor:

Richard S. Lord, Cheryl K. Burdette, and J. Alexander Bralley

Significance of Urinary Tartaric Acid
Clin Chem 2005 51: 672-673. [Extract] [Full Text] [PDF]  

Jane Starczynski, Laura Hooper, Nageeb Ali, Mark Hill, Chris Fegan, and Guy Pratt

Genetic Screening for Hemochromatosis: A Cautionary Tale
Clin Chem 2005 51: 673. [Extract] [Full Text] [PDF]  

William W.L. Choi, Sumathi Srivatsa, and James C. Ritchie

Aberrant Thyroid Testing Results in a Clinically Euthyroid Patient Who Had Received a Tumor Vaccine
Clin Chem 2005 51: 673-675. [Extract] [Full Text] [PDF]  

Henrik Zetterberg

Increased Serum Concentrations of Intestinal Alkaline Phosphatase in Peritoneal Dialysis
Clin Chem 2005 51: 675-676. [Extract] [Full Text] [PDF]  

Maki Hyodo, Osamu Samura, Norio Miharu, Koso Ohama, and Yoshiki Kudo

Molar DNA in Maternal Serum in a Case of 46,XY Heterozygous Complete Hydatidiform Mole Coexisting with a 46,XX Twin Live Fetus
Clin Chem 2005 51: 676-677. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

David A. Lawrence

Flow Cytometry Protocols, 2nd edition. Methods in Molecular Biology, Volume 263. Teresa S. Hawley and Robert G. Hawley, editors. Totowa, NJ: Humana Press, 2004, 448 pp, $99.50, softcover. ISBN 1-588-29-235-5.
Clin Chem 2005 51: 678-679. [Extract] [Full Text] [PDF]  

Michael Kleerekoper

Osteoporosis—From Pathophysiology to Treatment: Special Topics in Diagnostic Testing. Catherine A. Hammett-Stabler. Washington, DC: AACC Press, 2004, 105 pp., $27.00 ($22.00 AACC members), softcover. ISBN 1-59425-005-7.
Clin Chem 2005 51: 679. [Extract] [Full Text] [PDF]  

Larry Broussard

Disposition of Toxic Drugs and Chemicals in Man, Seventh Edition. Randall C. Baselt. Foster City, CA: Biomedical Publications, 2004, 1250 pp., $139.50, hardcover. ISBN 09626523-6-9.
Clin Chem 2005 51: 680. [Extract] [Full Text] [PDF]  

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